IP Library › Granted Patent US 7,939,675
Granted Patent B2
US 7,939,675 · App. 11/666,707 · Granted May 10, 2011

Process for forming amorphous atorvastatin

View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 7,939,675
App. No.
11/666,707
Granted
May 10, 2011
Kind
B2
Abstract

A process for forming amorphous atorvastatin comprising the steps of dissolving atorvastatin in a non-hydroxylic solvent and removing the solvent by freeze-drying, as well as processes of dissolving atorvastatin in a hydroxylic solvent with a solubilizing agent or an alkalizing agent or an antioxidant and removing the solvent by freeze-drying to afford amorphous atorvastatin.

Claims (5)

1. A process for forming amorphous atorvastatin comprising:

(a) dissolving atorvastatin in a water solvent with a solubilizing agent selected from a group consisting of: a polyoxyethylene fatty acid ester and a cyclodextrin; and

(b) lyophilizing the solution to afford said amorphous atorvastatin.

2. The process of claim 1 wherein the solubilizing agent is selected from the group consisting of polysorbate 80 and a cyclodextrin.

3. The process of claim 2 wherein the cyclodextrin is beta-cyclodextrin.

Assignments (2)
CHANGE OF NAME Recorded Oct 31, 2022
From: UPJOHN US 1 LLC
To: VIATRIS SPECIALTY LLC.
Reel/Frame 061808/0420 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 6, 2020
From: PFIZER INC.
To: UPJOHN US 1 LLC
Reel/Frame 054293/0154 →