Multi-part substitution infusion fluids and matching anticoagulants
View Patent ↗A multi-part substitution infusion fluid for an extracorporeal blood treatment and methods for using same are provided. Generally, the multi-part substitution fluid comprises a first solution composed of electrolites but without divalent cations and a second solution comprising divalent cations. Another embodiment includes a third solution comprising a matching citrate/citric acid anticoagulant. The described methods of using the multi-part substitution infusion fluids significantly reduce risks associated with various extracorporeal blood treatments.
1. A three part system for extracorporeal blood treatment comprising:
a first aqueous infusion fluid comprising sodium ion, potassium ion, chloride ion and phosphate ion;
a second aqueous infusion fluid comprising calcium ion and from about 2.5 mmol/L to about 20 mmol/L of magnesium ion; and
a citrate anticoagulant solution comprising from about 19 mmol/L to about 135 mmol/L of citric acid and from about 80 mmol/L to about 550 mmol/L of trisodium citrate.
2. The three part system for extracorporeal blood treatment according to claim 1 , wherein the second aqueous infusion fluid has from about 10 mmol/L to about 35 mmol/L of the calcium ion.
3. The three part system for extracorporeal blood treatment according to claim 1 , wherein the first aqueous infusion fluid has from about 70 mmol/L to about 130 mmol/L of the sodium ion.
4. The three part system for extracorporeal blood treatment according to claim 1 , wherein the first aqueous infusion fluid has from about 0.01 mmol/L to about 5 mmol/L of the potassium ion.
5. The three part system for extracorporeal blood treatment according to claim 1 , wherein the first aqueous infusion fluid has from about 100 mmol/L to about 150 mmol/L of the chloride ion.
6. The three part system for extracorporeal blood treatment according to claim 1 , wherein the first aqueous infusion fluid has from about 0.01 mmol/L to about 1.5 mmol/L of the phosphate ion.
7. The three part system for extracorporeal blood treatment according to claim 1 , wherein the first aqueous infusion fluid further comprises from about 2 mmol/L to about 11.5 mmol/L of glucose.
8. The three part system for extracorporeal blood treatment according to claim 7 , wherein the second aqueous infusion fluid further comprises from about 30 mmol/L to about 100 mmol/L selected from a group consisting of sulphate, gluconate, glubionate and chloride ion.
9. The three part system for extracorporeal blood treatment according to claim 1 , wherein the first aqueous infusion fluid further comprises amino acids and/or trace elements.
10. The three part system for extracorporeal blood treatment according to claim 1 further comprising ions selected from a group consisting of iron, zinc, copper and manganese.