Process for preparation of diphosphine compounds and intermediates for the process
View Patent ↗A production method of a compound represented by the formula wherein R 1a , R 1b , R 1c , R 1d , R 1e , R 1f , R 2a , R 2b , R 2c , R 2d , R 2e and R 2f are the same or different and each is a hydrogen atom and the like, and R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 and R 10 are the same or different and each is a hydrogen atom and the like, or a salt thereof, which comprises reacting a compound represented by the formula wherein X is a leaving group and other symbols are as defined above, or a salt thereof, with a phosphine-borane complex represented by the formula wherein the symbols are as defined above, or a salt thereof, in a solvent in the presence of an amine and a nickel catalyst, is provided.
1. A phosphine-borane complex represented by the formula
wherein R 3′ , R 5′ , R 6′ and R 8′ are each a lower alkyl group, and R 4′ and R 7′ are each a hydrogen atom, or a salt thereof.
2. A phosphine-borane complex represented by the formula
wherein R 3′ , R 5′ , R 6′ and R 8′ are each a lower alkyl group, and R 4′ and R 7′ are each a lower alkoxy group, or a salt thereof.
3. A phosphine-borane complex represented by the formula
wherein R 5′ and R 6′ are each a hydrogen atom, and R 3′ and R 4′ , and R 7′ and R 8′ each form a methylenedioxy group, or a salt thereof.
4. A method of producing a phosphine-borane complex represented by the formula
wherein R 3′ , R 5′ , R 6′ and R 8′ are each a lower alkyl group, and R 4′ and R 7′ are each a hydrogen atom, or a salt thereof,
said method comprising reducing a compound represented by the formula
wherein R 3′ , R 4′ , R 5′ , R 6′ , R 7′ and R 8′ are as defined above, or a salt thereof, with lithium aluminum hydride in the presence of cerium chloride and sodium borohydride.
5. A method of producing a phosphine-borane complex represented by the formula
wherein R 3′ , R 5′ , R 6′ and R 8′ are each a lower alkyl group, and R 4′ and R 7′ are each a lower alkoxy group, or a salt thereof,
said method comprising reducing a compound represented by the formula
wherein R 3′ , R 4′ , R 5′ , R 6′ , R 7′ and R 8′ are as defined above, or a salt thereof, with lithium aluminum hydride in the presence of cerium chloride and sodium borohydride.
6. A method of producing a phosphine-borane complex represented by the formula
wherein R 5′ and R 6′ are each a hydrogen atom, and R 3′ and R 4′ , and R 7′ and R 8′ each form a methylenedioxy group, or a salt thereof,
said method comprising reducing a compound represented by the formula
wherein R 3′ , R 4′ , R 5′ , R 6′ , R 7′ and R 8′ are as defined above, or a salt thereof, with lithium aluminum hydride in the presence of cerium chloride and sodium borohydride.