Methods and systems for occluding collateral flow channels in the lung
View Patent ↗The lateral flow between adjacent lung segments is occluded by blocking collateral flow channels with particles. A gas flow is established from one lung segment through the flow channels in an intermediate fibrous septum, and out through the adjacent lung segment. Particles entrained in the gas flow become lodged in the collateral flow channels to eventually block flow.
1. A method for occluding collateral flow channels between adjacent lung segments, said method comprising:
providing a distribution of particles having a composition and a range of sizes from 100 μm to 1000 μm selected to lodge in and occlude the collateral flow channels;
establishing a gas flow through the collateral flow channels in a wall between the at least two adjacent lung segments; and
entraining the particles in said gas flow, wherein the particles lodge in the flow channels to occlude collateral flow.
2. A method as in claim 1 , wherein the particles are composed at least partly from a material selected from the group consisting of silicones, polyurethanes, collagen, hydroxy apatites, sol-gels, ceramic sol-gels, bone cements, and hemo glues.
3. A method as in claim 1 , wherein the particles are composed of a hydrogel.
4. A method as in claim 1 , wherein the particles have a surface that has been modified to induce an inflammatory response when implanted.
5. A method as in claim 1 , wherein the collateral channels have walls, and the particles induce adherence of the walls of the collateral channels to close and adhere.
6. A method as in claim 1 , wherein the particles release a drug which promotes tissue ingrowth.
7. A method as in claim 6 , wherein the drug is selected from the group comprising collagen and/or any derivative drug that promotes tissue growth.
8. A method as in claim 1 , wherein establishing comprises:
sealing a distal end of a catheter in an airway feeding a target lung segment, wherein the catheter provides an isolated passage between the target lung segment and an exterior location.
9. A method as in claim 8 , wherein entraining comprises:
combining the particles with a carrier gas being fed into the target lung segment through the isolated passage in the catheter.
10. A method as in claim 9 , wherein the carrier gas comprises excess oxygen to induce or promote absorption atelectasis.
11. A method as in claim 10 , further comprising exhaling through a path which bypasses isolated passage in the catheter.
12. A method as in claim 11 , wherein the bypass path is through a separate passage in the catheter.
13. A method as in claim 11 , wherein the bypass path is through an annular region surrounding the catheter.
14. A method as in claim 8 , wherein entraining comprises:
combining the particles with a carrier gas being fed to a lung segment adjacent to the target lung segment, wherein the carrier gas carries the particles into the collateral flow channels and the gas is exhaled at least partially through the isolated passage.
15. A method as in claim 14 , wherein the carrier gas is introduced through a second passage in the catheter which releases the carrier gas upstream of the sealed distal end of the catheter.
16. A method as in claim 14 , further comprising blocking all gas flow to and from the target and adjacent lung compartment(s) other than through the catheter passage(s).
17. A method as in claim 16 , wherein blocking comprises inflating a cuff on a bronchoscope, wherein the catheter passes through a passage in the bronchoscope.