Inhibitors of histone deacetylase
View Patent ↗The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.
1. A compound of formula 1a-2:
wherein W is S or NH; R 8 is H or C 1 -C 4 alkyl; and A is selected from C 1 -C 4 alkyl, haloalkoxy and heteroarylalkoxy, alkoxyalkyl, haloalkyl, amino, nitro, alkylthio, acylamino, carbamoyl,
and B is selected from H, halogen, C 1 -C 4 alkyl, haloalkoxy and heteroarylalkoxy, alkoxyalkyl, haloalkyl, nitro, alkylthio, acylamino, carbamoyl,
2. A composition comprising one or more compounds according to claim 1 and a pharmaceutically acceptable carrier, excipient, or diluent.
3. A compound of formula 1a-2:
wherein W is S or NH; R 8 is H or C 1 -C 4 alkyl; and A is selected from C 1 -C 4 alkyl, haloalkoxy and heteroarylalkoxy, alkoxyalkyl, haloalkyl, nitro, alkylthio, acylamino, carbamoyl,
and B is selected from H, halogen, C 1 -C 4 alkyl, haloalkoxy and heteroarylalkoxy, alkoxyalkyl, haloalkyl, nitro, alkylthio, acylamino, carbamoyl,
4. A composition comprising one or more compounds according to claim 3 and a pharmaceutically acceptable carrier, excipient, or diluent.