IP Library › Patent Application 11690026
Patent Application
App. No. 11/690,026

USE OF (-)(3-TRIHALOMETHYLPHENOXY)(4-HALOPHENYL) ACETIC ACID DERIVATIVES FOR TREATMENT OF INSULIN RESISTANCE, TYPE 2 DIABETES AND HYPERLIPIDEMIA

Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US None
App. No.
11/690,026
Abstract

The present invention provides the use of (−)(3-trihalomethylphenoxy)(4-halophenyl)acetic acid derivatives and compositions in the treatment of insulin resistance, Type 2 diabetes and hyperlipidemia.

Claims (26)

1 - 49 . (canceled)

50 . A pharmaceutical composition comprising a therapeuticallyeffective amount of the (−) stereoisomer of a compound of the formula:

or its pharmaceutically acceptable salt, wherein said formula R 2 is a hydrogen, C 2 -C 12 aliphatic alcohol that can or can not contain one or more double bonds and can or can not contain branched carbons and lower alkanamido lower alkyl, and the (−) stereoisomer of the compound is substantially free of its (+) stereoisomer, and wherein the composition is formulated for oral administration in unit dose format.

51 . The composition of claim 50 , wherein the (−) stereoisomer is (−)2-acetamidoethyl 4-chlorophenyl-(3-trifluoromethylphenoxy)-acetate or (−)4-chlorophenyl-(3-trifluoromethylphenoxy)-acetic acid.

52 . The composition of claim 50 , wherein the composition comprises a at least one filler and cross-linked polyvinylpyrrolidone.

53 . The composition of claim 52 , wherein the filler comprises a starch.

54 . The composition of claim 52 , wherein the filler comprises a cellulose preparation.

55 . The composition of claim 52 , wherein the filler comprises a starch and a cellulose preparation.

56 . The composition of claim 50 , wherein the composition comprises a filler, a binder and a lubricant.

57 . The composition of claim 56 , wherein the lubricant is magnesium stearate.

58 . The composition of claim 56 , wherein the binder is a starch.

59 . The composition of claim 57 , wherein the binder is a starch.

60 . The composition of claim 50 , wherein the composition is in the form of a tablet.

61 . The composition of claim 55 , wherein the (−) stereoisomer is (−)2-acetamidoethyl 4-chlorophenyl-(3-trifluoromethylphenoxy)-acetate or (−)4-chlorophenyl-(3-trifluoromethylphenoxy)-acetic acid.

62 . The composition of claim 61 , wherein the (−) stereoisomer and the (+) stereoisomer are in an enantiomeric ratio of at least 98%.

63 . The composition of claim 59 , wherein the (−) stereoisomer is (−)2-acetamidoethyl 4-chlorophenyl-(3-trifluoromethylphenoxy)-acetate or (−)4-chlorophenyl-(3-trifluoromethylphenoxy)-acetic acid.

64 . The composition of claim 63 , wherein the (−) stereiosimer and the (+) stereoisomer are in an enantiomeric ratio of at least 98%.

65 . The composition of claim 50 , wherein the therapeutically effective amount is from 10 to about 1500 mg.

66 . The composition of claim 62 , wherein the therapeutically effective amount is from 100 to 3000 mg.

67 . The composition of claim 62 , wherein the therapeutic amount is from 100 to 500 mg.

68 . The composition of claim 64 , wherein the therapeutically effective amount is from about 100 to 3000 mg.

69 . The composition of claim 64 , wherein the therapeutic amount is from 100 to 500 mg.

70 . The composition of claim 50 , wherein the composition is in solid format.

71 . The composition of claim 50 , wherein the composition is in the form of a tablet, capsule, pill, powder, granule, or dragee core.

72 . The composition of claim 50 , wherein the composition comprises a filler, a binder, a lubricant and a stabilizer.

73 . The composition of claim 72 , wherein the composition further comprises polyethylene glycol.

Assignments (2)
CORRECTIVE ASSIGNMENT TO CORRECT THE NATURE OF CON Recorded Jul 16, 2009
From: METABOLEX, INC.
To: DIATEX, INC.
Reel/Frame 022973/0618 →
LICENSE Recorded Jun 17, 2009
From: METABOLEX, INC.
To: DIATEX, INC.
Reel/Frame 022835/0388 →