PRENYLTRANSFERASE INHIBITORS FOR OCULAR HYPERTENSION CONTROL AND THE TREATMENT OF GLAUCOMA
The invention concerns in one embodiment a method of treating glaucoma or elevated intraocular pressure comprising administering a pharmaceutically effective amount of a composition comprising at least one prenyltransferase inhibitor. In another embodiment, the invention concerns a composition for the treatment of elevated intraocular pressure and glaucoma comprising a pharmaceutically effective amount of a prenyltransferase inhibitor.
1 . A method of treating glaucoma or elevated intraocular pressure comprising:
administering a pharmaceutically effective amount of a composition comprising at least one prenyltransferase inhibitor.
2 . The method of claim 1 wherein said at least one prenyltransferase inhibitor is a geranylgeranyltransferase inhibitor or a farnesyltransferase inhibitor.
3 . The method of claim 1 wherein said administering comprises administering a composition comprising at least one geranylgeranyltransferase inhibitor and at least one farnesyltransferase inhibitor.
4 . The method of claim 1 wherein said composition further comprises a compound selected from the group consisting of:
ophthalmologically acceptable preservatives, surfactants, viscosity enhancers, penetration enhancers, gelling agents, hydrophobic bases, vehicles, buffers, sodium chloride, and water.
5 . The method of claim 1 , further comprising administering, either as part of said composition or as a separate administration, a compound selected from the group consisting of:
β-blockers, prostaglandin analogs, carbonic anhydrase inhibitors, α 2 agonists, miotics, neuroprotectants, and any combination thereof.
6 . The method of claim 1 wherein said composition comprises from about 0.01 percent weight/volume to about 5 percent weight/volume of said at least one prenyltransferase inhibitor.
7 . The method of claim 1 wherein said composition comprises from about 0.25 percent weight/volume to about 2 percent weight/volume of said prenyltransferase inhibitor.
8 . A composition for the treatment of elevated intraocular pressure and glaucoma comprising:
a pharmaceutically effective amount of a prenyltransferase inhibitor.
9 . The composition of claim 8 wherein said prenyltransferase inhibitor is a geranylgeranyltransferase inhibitor or a farnesyltransferase inhibitor.
10 . The composition of claim 8 , further comprising a compound selected from the group consisting of:
ophthalmologically acceptable preservatives, surfactants, viscosity enhancers, penetration enhancers, gelling agents, hydrophobic bases, vehicles, buffers, sodium chloride, and water.
11 . The composition of claim 8 wherein said composition comprises from about 0.01 percent weight/volume to about 5 percent weight/volume of said prenyltransferase inhibitor.
12 . The composition of claim 8 wherein said composition comprises from about 0.25 percent weight/volume to about 2 percent weight/volume of said prenyltransferase inhibitor.
13 . The composition of claim 8 wherein said composition further comprises a compound selected from the group consisting of:
β-blockers, prostaglandin analogs, carbonic anhydrase inhibitors, α 2 agonists, miotics, neuroprotectants, rho kinase inhibitors, and any combination thereof.
14 . The composition of claim 8 wherein said prenyltransferase inhibitor is selected from the group consisting of:
GGTI-286, GGTI-287, GGTI-297, GGTI-298, GGTI-2133, GGTI-2147, FTI-276, FTI-277, FTI-2148, FTI-2153, R115777, combinations thereof, and pharmaceutically acceptable salts thereof.
15 . A method of treating glaucoma or elevated intraocular pressure, which comprises administering to a human or other mammal a therapeutically effective amount of a compound selected from the group consisting of:
GGTI-286, GGTI-287, GGTI-297, GGTI-298, GGTI-2133, GGTI-2147, FTI-276, FTI-277, FTI-2148, FTI-2153, R115777, combinations thereof, and pharmaceutically acceptable salts thereof.