Flow-path inserts for wet/dry automatic injectors
View Patent ↗An automatic medicament injector having a compartment for a dry medicament component and a compartment for a wet medicament component. The two compartments are separated by a seal structure that converts from a sealing condition into a mixing condition when the device is activated. The seal structure includes a wiper that scrapes the interior walls in the dry component compartment to prevent the dry component from accumulating at the seal/glass interface. A tapered insert funnels the mixed medicament components to an attached needle assembly, but can be removed when the device is filled. A filter is provided between the medicament compartments and the needle assembly. A chamber between the filter and the needle allows for better flow through the filter. An actuation assembly drives the seal structure into the mixing condition and forces the mixed medicament through the needle and into the user.
1. An automatic injection device containing a pre-loaded charge of medicament for automatically self-administering the medicament upon actuation thereof, the device comprising:
a housing;
a medicament chamber disposed in the housing, the medicament chamber including a first compartment containing a first medicament portion, and a second compartment containing a second medicament portion to be mixed with the first medicament portion;
a seal structure between the first compartment and the second compartment, the seal structure being initially in a sealing condition that maintains the first compartment separate from the second compartment, the seal structure being converted to a mixing condition as a result of activation of the device;
a needle assembly that dispenses the medicament charge from the medicament chamber, the needle assembly having a rearward opening with a diameter that is less than a diameter of the medicament chamber;
an insert mounted in a forward end of the medicament chamber adjacent the needle assembly, the insert defining a tapering flow pathway that tapers radially inward as it extends axially forward, the insert having a constant radially-inward taper as fluid flows through the insert, the constant radially-inward taper extending from the end of the insert that forms a common boundary with the medicament chamber to the opposite end of the insert that forms a common boundary with the needle assembly;
an activation assembly carried by the housing and including a stored energy source, wherein activation of the activation assembly releases the stored energy from the stored energy source, causing the seal structure to be converted from the sealing condition to the mixing condition, and thereby causing or allowing the first and second medicament portions to be mixed, directed by the insert radially inward toward the rearward opening in the needle assembly, and forced through the needle assembly.
2. The automatic injection device of claim 1 further comprising a filter positioned between the medicament chamber and the needle assembly.
3. The automatic injection device of claim 2 wherein the needle assembly comprises a needle support for mounting the needle assembly to a front end of the medicament chamber, the needle support defining a needle support chamber adjacent the filter on a needle assembly side of the filter.
4. The automatic injection device of claim 3 wherein the rearward opening of the needle assembly comprises a rearward end opening in the needle support chamber adjacent to the filter, the rearward end opening having a size that is at least as large as a front end opening of the insert.
5. The automatic injection device of claim 4 further comprising a fluid distributing member carried by the seal structure.
6. The automatic injection device of claim 1 wherein the seal structure comprises an outer seal structure carrying a wiper portion, a flow path formed in the outer seal structure, and a plug member for sealing the flow path when the seal structure is in the sealing condition.
7. The automatic injection device of claim 6 wherein the seal structure has an outer periphery that forms a peripheral seal with an interior wall of the interior chamber, and wherein said plug member is spaced radially inward from the peripheral seal that seals the at least one flow path formed in the seal structure.
8. The automatic injection device of claim 7 wherein the wiper portion comprises a peripheral lip having an inner surface that extends radially inward as it extends axially rearward.
9. The automatic injection device of claim 1 wherein the insert further comprises an annular sealing flange that abuts an outside edge of the forward end of the medicament chamber.
10. An automatic injection device containing a pre-loaded charge of medicament for automatically administering the medicament upon actuation thereof, the device comprising:
a housing;
a chamber disposed in the housing, the chamber including a first compartment containing a first medicament portion, and a second compartment containing a second medicament portion to be mixed with the first medicament portion;
a seal structure between the first compartment and the second compartment, the seal structure initially in a sealed condition that maintains the first compartment separate from the second compartment, the seal structure converting to a mixing condition in response to activation of the device;
a needle assembly that dispenses the medicament charge from the chamber, the needle assembly having a rearward opening with a diameter that is less than a diameter of a forward end of the chamber;
an insert mounted in the forward end of the chamber adjacent the needle assembly, the insert comprising a funnel portion having an outside surface that sealingly engages the inner wall of the chamber, the funnel portion having a small opening at one end of the insert facing the needle assembly and a large opening at an opposite end of the insert facing the chamber, the funnel portion having a flow-path that tapers radially inward from the chamber to the needle assembly, the funnel portion having a constant radially-inward taper from the large opening to the small opening as fluid flows through the funnel portion; and
an activation assembly disposed in the housing and including a stored energy source, wherein activation of the activation assembly releases the stored energy from the stored energy source causing the seal structure to convert from the sealed condition to the mixing condition, wherein the first and second medicament portions are mixed, directed by the insert radially inward toward the rearward opening in the needle assembly, and forced through the needle assembly.
11. The automatic injection device of claim 10 wherein the insert further comprises an annular sealing flange that abuts an outside edge of the forward end of the chamber.
12. The automatic injection device of claim 10 wherein the insert further comprises an annular sealing flange that forms a seal between the chamber and the needle assembly.
13. The automatic injection device of claim 10 wherein the insert further comprises an annular sealing flange located at the end of the funnel portion having the small opening.
14. The automatic injection device of claim 10 wherein a burstable membrane is positioned in the funnel portion of the insert.
15. The automatic injection device of claim 10 wherein the insert is made of an elastomeric or rubber material.
16. The automatic injection device of claim 10 wherein the large and small openings of the funnel portion are centrally located at their respective ends of the insert.
17. The automatic injection device of claim 10 wherein the funnel portion adjacent the large opening is inserted into the first compartment of the chamber.
18. The automatic injection device of claim 10 further comprising a filter covering the large opening of the funnel portion to prevent undissolved medicament from entering the needle assembly.
19. The automatic injection device of claim 10 wherein the forward end of the chamber has an open mouth configuration.
20. The automatic injection device of claim 10 further comprising a filter covering the small opening of the funnel portion to prevent undissolved medicament from entering the needle assembly.