Corticotropin releasing factor 2 receptor agonists

1. An isolated nucleic acid encoding a non-native peptide, wherein the non-native peptide comprises the sequence

ZGPPISIDLPX 11 X 12 LLRKX 17 IEIEKQEKEKQQAX 31 X 32 NAX 35 X 36 LX 38 X 39 X 40 (SEQ ID NO: 531);

wherein:

X 11 is selected from F, Y, L, I, and T;

X 12 is selected from Q, W, and Y;

X 17 is selected from V and M;

X 31 is selected from T and A;

X 32 is selected from N and T;

X 35 is selected from R and L;

X 36 is selected from L and I;

X 38 is selected from D and A;

X 39 is selected from T and R; and

X 40 is selected from I and V;

and variants thereof having at least 95% sequence identity to said peptide.

2. An isolated nucleic acid according to claim 1 , wherein the variant has at least 97% sequence identity to said non-native peptide.

3. An isolated nucleic acid encoding for a non-native peptide, wherein the non-native peptide comprises the sequence of SEQ ID NO: 278, and variants thereof having at least 95% sequence identity to said non-native peptide.

4. An isolated nucleic acid according to claim 3 , wherein the variant has at least 97% sequence identity to said non-native peptide.

5. An isolated nucleic acid according to claim 1 , wherein X 11 is selected from F, L, T, and Y.

6. An isolated nucleic acid according to claim 1 , wherein X 11 X 12 are selected from the group consisting of FQ, YQ, YW, LQ, LY, IY, and TY.

7. An isolated nucleic acid according to claim 6 , wherein X 31 X 32 are selected from the group consisting of AN, and TT.

8. An isolated nucleic acid according to claim 7 , wherein X 35 X 36 are selected from the group consisting of RL, LL, and RI.

9. An isolated nucleic acid according to claim 7 , wherein X 38 X 39 X 40 are selected from the group consisting of DTI, ARI, ATI, DRV, and ARV.

10. An isolated nucleic acid according to claim 6 , wherein X 35 X 36 are selected from the group consisting of RL, LL, and RI.

11. An isolated nucleic acid according to claim 6 , wherein X 38 X 39 X 40 are selected from the group consisting of DTI, ARI, ATI, DRV, and ARV.

12. An isolated nucleic acid according to claim 1 , wherein X 31 X 32 are selected from the group consisting of AN, and TT.

13. An isolated nucleic acid according to claim 12 , wherein X 35 X 36 are selected from the group consisting of RL, LL, and RI.

14. An isolated nucleic acid according to claim 13 wherein X 38 X 39 X 40 are selected from the group consisting of DTI, ARI, ATI, DRV, and ARV.

15. An isolated nucleic acid according to claim 12 , wherein X 38 X 39 X 40 are selected from the group consisting of DTI, ARI, ATI, DRV, and ARV.

16. An isolated nucleic acid according to claim 1 , wherein X 35 X 36 are selected from the group consisting of RL, LL, and RI.

17. An isolated nucleic acid according to claim 16 , wherein X 38 X 39 X 40 are selected from the group consisting of DTI, ARI, ATI, DRV, and ARV.

18. An isolated nucleic acid according to claim 1 , wherein X 38 X 39 X 40 are selected from the group consisting of DTI, ARI, ATI, DRV, and ARV.

19. An isolated nucleic acid according to claim 1 , wherein the non-native peptide comprises a sequence selected from the group consisting of SEQ ID NO: 22, 144, 148, 149, 151, 278, 279, 286, 288, 311, 349, 350, 351, 352, and 353.

20. An isolated nucleic acid encoding for a non-native peptide, wherein the non-native peptide comprises the sequence

ZGPPISIDLPX 11 X 12 LLRKX 17 IEIEKQEKEKQQAX 31 X 32 NAX 35 X 36 LX 38 X 39 X 40 (SEQ ID NO: 531);

wherein:

X 11 is selected from F, Y, L, I, and T;

X 12 is selected from Q, W, and Y;

X 17 is selected from V and M;

X 31 is selected from T and A;

X 32 is selected from N and T;

X 35 is selected from R and L;

X 36 is selected from L and I;

X 38 is selected from D and A;

X 39 is selected from T and R; and

X 40 is selected from I and V.

21. An isolated nucleic acid encoding for a non-native peptide, wherein the non-native peptide comprises the sequence of SEQ ID NO: 278.