Corticotropin releasing factor 2 receptor agonists
View Patent ↗Isolated corticotropin releasing factor derivatives, and nucleic acids encoding the same, are effective for treating corticotropin releasing factor 2 receptor modulated disorders such as muscular dystrophy.
1. An isolated nucleic acid encoding for a non-native peptide, wherein the non-native peptide comprises the sequence
(SEQ ID NO: 531)
X 1 X 2 PSLSIDX 9 PX 11 X 12 LLRTLLELEKTQSQRERAEQNAX 35 IFAX 39
V;
wherein:
X 1 is selected from nil and D;
X 2 is selected from nil and N;
X 9 is selected from L and V;
X 11 is selected from L and F;
X 12 is selected from L, F and Y;
X 35 is selected from R, H and Q; and
X 39 is selected from H and R;
and variants thereof having at least 95% sequence identity to said peptide.
2. An isolated nucleic acid according to claim 1 , wherein X 1 X 2 are selected from the group consisting of DN, and nil nil.
3. An isolated nucleic acid according to claim 1 , wherein X 11 X 12 are selected from the group consisting of LL, LF, FF, and LY.
4. An isolated nucleic acid according to claim 2 , wherein X 11 X 12 are selected from the group consisting of LL, LF, FF, and LY.
5. An isolated nucleic acid according to claim 1 , wherein X 9 is L.
6. An isolated nucleic acid according to claim 1 , wherein X 35 is R.
7. An isolated nucleic acid according to claim 1 , wherein X 39 is R.
8. An isolated nucleic acid according to claim 1 , wherein the non-native peptide comprises a sequence selected from the group consisting of SEQ ID NO: 324, 328, 331, 333, 334, 341, 384, 385, 386, and 387.
9. An isolated nucleic acid according to claim 1 , wherein the variant has at least 97% sequence identity to said non-native peptide.
10. An isolated nucleic acid encoding for a non-native peptide, wherein the non-native peptide comprises the sequence of SEQ ID NO: 341, and variants thereof having at least 95% sequence identity to said non-native peptide.
11. An isolated nucleic acid according to claim 10 , wherein the variant has at least 97% sequence identity to said non-native peptide.
12. An isolated nucleic acid encoding for a non-native peptide, wherein the non-native peptide comprises the sequence of SEQ ID NO: 341.
13. An isolated nucleic acid encoding for a non-native peptide, wherein the non-native peptide comprises the sequence:
(SEQ ID NO: 531)
X 1 X 2 PSLSIDX 9 PX 11 X 12 LLRTLLELEKTQSQRERAEQNAX 35 IFAX 39
V;
wherein:
X 1 is selected from nil and D;
X 2 is selected from nil and N;
X 9 is selected from L and V;
X 11 is selected from L, and F;
X 12 is selected from L, F, and Y;
X 35 is selected from R, H, and Q; and
X 39 is selected from H and R.