Intravascular device for neuromodulation
The present disclosure describes intravascular systems that may be used for a variety of functions. The elements of the disclosed systems include at least one device body implanted within the vasculature. Electrodes on a lead and/or on the device body itself are used to direct electrical energy to neurological targets. These systems may additionally include one or more fluid reservoirs housing drugs or other agents to be delivered to tissue.
1. A method of electrically stimulating a nervous system target and delivering an agent into a blood vessel, the method comprising:
selecting a nervous system target to receive electrical stimulation;
introducing a neurostimulation implant including a pulse generator into the vasculature of a patient and advancing the neurostimulation implant to a first blood vessel;
retaining the neurostimulation implant within the first blood vessel; and
positioning at least one electrode within the patient, the electrode in communication with the neurostimulation implant, and
stimulating the nervous system target using the electrode;
providing an intravascular drug delivery implant comprising a reservoir;
introducing the drug delivery implant into a second blood vessel;
retaining the drug delivery implant within the second blood vessel; and
releasing agent from the reservoir into the cardiovascular system.
2. The method according to claim 1 , wherein the neurostimulation implant includes the reservoir.
3. The method according to claim 1 , wherein the neurostimulation implant is electronically coupled to the drug delivery implant.
4. The method according to claim 1 , wherein the neurostimulation implant is in wireless communication with the drug delivery implant.
5. The method of claim 1 , wherein the drug delivery implant includes an elongate conduit extending from the reservoir, and the method includes positioning the conduit to release agent into a target region of the cardiovascular system.
6. The method of claim 5 , wherein the target region of the cardiovascular system is a third blood vessel, and wherein the method includes positioning the conduit to release agent into the third blood vessel.
7. The method of claim 6 , wherein the third blood vessel is a renal artery.
8. The method of claim 5 , wherein the target region is an organ.
9. The method of claim 8 , wherein the organ is the heart.
10. The method of claim 5 , wherein the organ is a kidney.
11. The method according to claim 5 , further including passing the conduit through a wall of the second blood vessel and positioning the conduit to release an agent into contact with the nervous system target.
12. The method according to claim 11 , further including extending the conduit into tissue of the nervous system target.