Crystal form and pharmaceutical compositions of (+)-R-zileuton
View Patent ↗Crystalline forms of (+)-R-zileuton, which may be used in pharmaceutical applications, are disclosed. Particular single crystalline forms of (+)-R-zileuton are characterized by a variety of properties and physical measurements. As well, methods of producing crystalline (+)-R-zileuton, and using it to inhibit 5-lipoxygenase activity in subjects to treat a number of diseases, are also discussed.
1. A composition comprising (+)-R-zileuton represented by the following structural formula:
wherein at least 70% by weight of the composition is the single crystalline form Form I of (+)-R-zileuton, characterized by major x-ray powder diffraction peaks at 2θ angles of 4.5°, 9.1°, 16.3°, 17.3°, 17.9°, 20.3°, 22.2° and 24.0°.
2. The composition of claim 1 , wherein the single crystalline form is characterized by x-ray powder diffraction peaks at 2θ angles of 4.5°, 9.1°, 16.3°, 17.3°, 17.9°, 20.3°, 22.2°, 22.7° and 24.0°.
3. The composition of claim 1 , wherein the single crystalline form is characterized by x-ray powder diffraction pattern of FIG. 1 .
4. The composition of claim 1 , wherein the single crystalline form is characterized by a single endothermic transition at 151° C. in the differential scanning calorimetry profile with a scanning rate of 10° C./minute or the single crystalline form is anhydrous.
5. A pharmaceutical composition comprising a pharmaceutically acceptable carrier or diluent and the composition of claim 1 .
6. The pharmaceutical composition of claim 1 , wherein the single crystalline form is characterized by x-ray powder diffraction peaks at 2θ angles of 4.5°, 9.1°, 16.3°, 17.3°, 17.9°, 20.3°, 22.2°, 22.7° and 24.0°.
7. The pharmaceutical composition of claim 1 , wherein the single crystalline form is characterized by x-ray powder diffraction pattern of FIG. 1 .
8. The pharmaceutical composition of claim 1 , wherein the single crystalline form is characterized by a single endothermic transition at 151° C. in the differential scanning calorimetry profile with a scanning rate of 10° C./minute or the single crystalline form is anhydrous.
9. The pharmaceutical composition of claim 5 wherein at least 99% by weight of the (+)-R-zileuton is the single crystalline form.
10. The pharmaceutical composition of claim 5 wherein at least 99.9% by weight of the (+)-R-zileuton is the single crystalline form.
11. A composition comprising (+)-R-zileuton represented by the following structural formula:
wherein at least 70% by weight of (+)-R-zileuton is a single crystalline form Form II of (+)-R-zileuton characterized by major x-ray powder diffraction peaks at 2θ angles of 4.6°, 9.2°, 16.1°, 16.3°, 17.6°, 18.6°, 19.9°, 21.3°, 23.4° and 23.7°.
12. The composition of claim 11 , wherein the single crystalline form is characterized by x-ray powder diffraction pattern of FIG. 4 .
13. A pharmaceutical composition comprising a pharmaceutically acceptable carrier or diluent and the composition of claim 11 .
14. The pharmaceutical composition of claim 13 , wherein the single crystalline form is characterized by x-ray powder diffraction pattern of FIG. 4 .
15. A method of treating asthma or nasal polyposis in a subject in need thereof comprising administering to the subject an effective amount of a pharmaceutical composition comprising a pharmaceutically acceptable carrier or diluent and (+)R-zileuton represented by the following structural formula:
wherein at least 70% by weight of the (+)-R-zileuton is crystalline Form I of (+)-R-zileuton characterized by major x-ray powder diffraction peaks at 2θ angles of 4.5°, 9.1°, 16.3°, 17.3°, 17.9°, 20.3°, 22.2° and 24.0°, or crystalline Form II of (+)-R-zileuton characterized by major x-ray powder diffraction peaks at 2θ angles of 4.6°, 9.2°, 16.1°, 16.3°, 17.6°, 18.6°, 19.9°, 21.3°, and 23.4°.