Methods and compositions for treating a renal associated condition in a subject
Methods for treating a renal associated condition in a subject are provided. Aspects of the subject methods include paradoxically enhancing renal sympathetic bias in the subject in a manner effective to treat the renal associated condition. Also provided are compositions, kits and systems for practicing the subject methods.
1. A method of treating a renal associated condition in a subject, said method comprising:
paradoxically enhancing renal sympathetic bias non-chronically in said subject in a manner effective to cause the subject to mount a compensatory response to the enhanced renal sympathetic bias to treat said renal associated condition, wherein said enhancing comprises non-chronically applying an electrical stimulus to said subject.
2. The method according to claim 1 , wherein said method comprises monitoring said subject.
3. The method according to claim 2 , wherein said method comprises applying a first stimulus to said subject and monitoring said subject for a response thereto; and applying a second stimulus to said subject, wherein said second stimulus is determined based on said monitored response to said first stimulus.
4. The method of claim 1 , wherein said renal associated condition comprises a member selected from the group consisting of acute renal failure, chronic renal failure, contrast nephropathy, cardiorenal syndrome, and hypertension.
5. The method of claim 4 , wherein said renal condition is cardiorenal syndrome.
6. The method of claim 4 , wherein said renal condition is contrast nephropathy.
7. The method of claim 6 , wherein said contrast nephropathy is iodine-based contrast nephropathy.
8. An algorithm recorded on a computer-readable medium for administering a stimulus to said subject in accordance with method of claim 1 .
9. A system comprising:
an algorithm recorded on a computer-readable medium for administering a stimulus to a subject according to a method of claim 1 ; and
a stimulus producing component, wherein said stimulus producing component is an electrical energy applying device.
10. A kit comprising:
a stimulus producing component, wherein said stimulus producing component is an electrical energy applying device; and
instructions for a stimulus to a subject according to the method of claim 1 .
11. The method according to claim 1 , wherein said renal sympathetic bias is enhanced at least about two-fold.
12. The method according to claim 1 , wherein said stimulus is applied for less than one week.
13. The method according to claim 1 , wherein applying said stimulus is followed by a holiday period in which no additional stimulus is administered to said subject, such that said subject is permitted to mount a compensatory response effective to treat said renal associated condition.
14. The method according to claim 13 , wherein said holiday period is at least about 1 day.
15. The method according to claim 1 , wherein said stimulus is applied in an irregularly irregular manner.