IP Library Granted Patent US 7,582,315
Granted Patent B2
US 7,582,315 · App. 11/713,969 · Granted Sep 1, 2009

Composition and method to augment and sustain neurotransmitter production

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Quick Facts
Patent No.
US 7,582,315
App. No.
11/713,969
Granted
Sep 1, 2009
Kind
B2
Abstract

This invention describes a method and composition to enhance the synthesis and release of the neurotransmitters by the oral administration of neurotransmitter precursors, along with natural plant substances that stimulate uptake of the neurotransmitters precursors, while adding natural plant substances that activate adenylate cyclase in order to avoid attenuation and prevent pharmacologic tolerance. The invention describes compositions for a medical foods that are designed to improve cognitive function, induced sleep, a improve Parasympathetic function, improve autonomic balance, increase nitric oxide production, reduce blood pressure, increase blood flow, and treat virus infections. The compositions include amino acids such as choline, herbs such ginkgo biloba, and other foods such as coca. The invention also describes the use of physiologic tests such as 24 hour ECG monitoring to create the appropriate combinations and assess the useful proportions.

Claims (17)

1. A method for enhancing serotonin neurotransmitter activity comprising orally administering to a subject in need thereof a composition comprising:

at least one first component selected from the group consisting of tryptophan and 5-hydroxytryptophan in the range of from about 1 mg to about 100 mg;

at least one second component selected from the group consisting of glutamine, predigested protein, Ginkgo biloba , ginseng, cinnamon, nutmeg, and St. John's Wort in the range of from about 1 mg to about 200 mg;

at least one third component selected from the group consisting of cocoa, caffeine, and theobromine in the range of from about 1 mg to about 200 mg;

at least one fourth component selected from the group consisting of neuroexcitatory amino acids, glutamate, glutamic acid, and glutamine in the range of from about 1 mg to about 200 mg; and

hawthorn berry as a fifth component in the range of from about 1 mg to about 200 mg;

wherein the proportions of the five or more components are determined by testing said subject using a physiologic test selected from the group consisting of heart rate, 24 hour Electrocardiogram analysis, blood pressure, body temperature, skin temperature, and a neurotransmitter blood test.

2. The method for enhancing serotonin neurotransmitter activity of claim 1 wherein said oral administration is provided in a form selected from the group consisting of capsules, suspension caplets, chewable wafers, tablets, or powders.

3. A method for enhancing neurotransmitter activity comprising: orally administering to a subject in need thereof a composition comprising:

at least one first component selected from the group consisting of choline and acetylcamitine in the range of from about 20 mg to about 100 mg;

at least one second component selected from the group consisting of tryptophan and 5-hydroxytryptophan in the range of from about 20 mg to about 100 mg;

at least one third component selected from the group consisting of Ginkgo biloba , ginseng, cinnamon, nutmeg, and echinacea in the range of from about 50 mg to about 100 mg;

at least one fourth component selected from the group consisting of cocoa, caffeine, and theobromine in the range of from about 100 mg to about 200 mg;

at least one fifth component selected from the group consisting of neuroexcitatory amino acids, glutamate, glutamic acid, and glutamine in the range of from about 20 mg to about 100 mg; and

hawthorn berry as a sixth component in the range of from about 20 mg to about 40 mg;

wherein the proportions of the six or more components are determined by testing said subject using a physiologic test selected from the group consisting of heart rate, 24 hour Electrocardiogram analysis, blood pressure, body temperature, skin temperature, and a neurotransmitter blood test.

4. The method for enhancing acetylcholine neurotransmitter activity of claim 3 wherein said oral administration is provided in a form selected from the group consisting of capsules, suspension caplets, chewable wafers, tablets, or powders.

Assignments (3)
CORRECTION BY DECLARATION FOR PATENT NUMBERS 7,582,315 AND 7,674,482 RECORDED AT REEL NUMBER 036053 AND FRAME NUMBERS 0700-0702 Recorded Apr 8, 2016
From: TARGETED MEDICAL PHARMA, INC.
To: TARGETED MEDICAL PHARMA, INC.
Reel/Frame 038389/0746 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 30, 2015
From: SHELL, WILLIAM
To: WILLIAM SHELL SURVIVORS TRUST
Reel/Frame 036053/0700 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 13, 2010
From: SHELL, WILLIAM E; CHARUVASTRA, ELIZABETH H
To: TARGETED MEDICAL PHARMA, INC.
Reel/Frame 025126/0722 →