Method of weaning from hormonal treatment of hormone depletion induced vasomotor symptoms
The invention provides a method to effectively wean a woman from hormonal therapy for treatment of vasomotor symptoms by reducing the dosage of the hormonal agent to zero, while a non-hormonal drug in an amount, which is therapeutically effective for treating vasomotor symptoms, is administered or initiated and continued for one or more periods of durations determined by assessment of the effect of a treatment free period, which follows each period of continuous non-hormonal drug treatment.
1 . A method to effectively wean a woman from hormonal therapy for treatment of vasomotor symptoms by reducing the dosage of the hormonal agent to zero, while a non-hormonal drug in an amount, which is therapeutically effective for treating vasomotor symptoms, is administered or initiated and continued for one or more periods of durations determined by assessment of the effect of a treatment free period, which follows each period of continuous non-hormonal drug treatment.
2 . The method according to claim 1 , wherein the non-hormonal drug is S-mirtazapine or a salt thereof.
3 . The method according to claim 1 , wherein the woman is after her menopause.
4 . The method according to claim 1 , wherein the non-hormonal drug is S-mirtazapine or a salt thereof, which is administered in an amount of 3 or 4.5 mg S-mirtazapine per day.
5 . The method according to claim 2 , wherein the woman is after her menopause.
6 . The method according to claim 2 , wherein the S-mirtazapine or a salt thereof is administered in an amount of 3 or 4.5 mg S-mirtazapine per day.
7 . The method according to claim 3 , wherein the non-hormonal drug is S-mirtazapine or a salt thereof, which is administered in an amount of 3 or 4.5 mg S-mirtazapine per day.