Synergistic preservative systems and their use in topical compositions
A synergistic preservative system having an oil-miscible glycol and an enzymatic composition. The synergistic preservative system demonstrates enhanced anti-fungal, anti-bacterial, and anti-microbial efficacy and is free of formaldehyde donors, parabens, ethanols, and isothiazolinones.
1 . A synergistic preservative system for use in a topical composition, comprising:
an oil-miscible glycol; and
an enzymatic composition,
wherein the synergistic preservative system demonstrates enhanced anti-fungal and/or anti-bacterial efficacy and is free of formaldehyde donors, parabens, ethanols, and isothiazolinones.
2 . The synergistic preservative system of claim 1 , wherein said oil-miscible glycol is caprylyl glycol.
3 . The synergistic preservative system of claim 1 , wherein said oil-miscible glycol is present in an amount between 0.1 wt. % and 5 wt. % based on the total weight of the topical composition.
4 . The synergistic preservative system of claim 1 , wherein said oil-miscible glycol is present in an amount between 0.25 wt. % and 5 wt. % based on the total weight of the topical composition.
5 . The synergistic preservative system of claim 1 , wherein said oil-miscible glycol is present in an amount between 1.25 wt. % and 2 wt. % based on the total weight of the topical composition.
6 . The synergistic preservative system of claim 1 , wherein said enzymatic composition comprises glucose, glucose oxidase and lactoperoxidase.
7 . The synergistic preservative system of claim 1 , wherein said enzymatic composition is present in said synergistic system in an amount about 1.05 wt. % based on the total weight of the topical composition.
8 . The synergistic preservative system of claim 6 , wherein said glucose is present in said enzymatic composition in an amount about 1.0 wt. % based on the total weight of the topical composition.
9 . The synergistic preservative system of claim 6 , wherein said glucose oxidase is present in said enzymatic composition in an amount between 1500 units/ml and 2750 units/ml, based on the total weight of the sum total of the glucose oxidase and lactoperoxidase present in the enzymatic composition.
10 . The synergistic preservative system of claim 6 , wherein said lactoperoxidase is present in said enzymatic composition in an amount between 1000 units/ml and 1800 units/ml, based on the total weight of the sum total of the combination of the glucose oxidase and lactose peroxidase present in the enzymatic composition.
11 . The synergistic preservative system of claim 1 , further comprising one or more preservative components.
12 . The synergistic preservative system of claim 11 , wherein said one or more preservative components is selected from the group consisting of essential oils, essential oil derivatives, plant extracts, plant extract derivatives, plant extract botanical derivatives, vegetable oils, vegetable oil derivatives, fatty acids, fatty acid derivatives, or any combinations thereof.
13 . The synergistic preservative system of claim 12 , wherein said plant extract botanical derivative comprises willow bark powder.
14 . A topical composition comprising:
a synergistic preservative system comprising an oil-miscible glycol and an enzymatic composition,
wherein the topical composition is free of formaldehyde donors, parabens, ethanols, and isothiazolinones.
15 . The topical composition of claim 14 , wherein said oil-miscible glycol is caprylyl glycol.
16 . The topical composition of claim 14 , wherein said oil-miscible glycol is present in said topical composition in an amount between 0.1 wt. % and 5 wt. % based on the total weight of the topical composition.
17 . The topical composition of claim 14 , wherein said enzymatic composition is present in said topical composition in an amount about 1.05 wt. % based on the total weight of the topical composition.
18 . The topical composition of claim 14 , wherein said enzymatic composition comprises glucose, glucose oxidase, and lactoperoxidase.
19 . The topical composition of claim 14 , wherein the topical composition is in a form selected from the group consisting of a lotion, cream, spray, gel, foam, powder, stick, or any combinations thereof.
20 . The topical composition of claim 14 , further comprising one or more additional ingredients selected from the group consisting of a solvent, a surfactant, a emulsifier, an emollient, a humectant, a moisturizer, a thickener, a botanical, an antioxidant, a vitamin, a sunscreen agent, a preservative, a pH adjuster, a chelating agent, a viscosity modifier, or any combinations thereof.
21 . The topical composition of claim 20 , wherein said botanical comprises willow bark powder.