Anti-demodicosis agent
View Patent ↗The present invention relates to the use of macrocyclic lactones for treating demodicosis, particularly in dogs.
1. A method of treating generalized demodicosis in a dog in need thereof comprising externally applying to the dog a spot-on formulation that comprises a macrocyclic lactone and a combination of solvents A and B, at most once a week, wherein the macrocyclic lactone comprises moxidectin, solvent A is benzyl alcohol or an optionally substituted pyrrolidone and solvent B is a cyclic carbonate or lactone.
2. A method of treating generalized demodicosis in a dog in need thereof comprising externally applying to the dog a spot-on formulation that comprises a mixture of imidacloprid, moxidectin, and a combination of solvents A and B, at most once a week, wherein solvent A is benzyl alcohol or an optionally substituted pyrrolidone, and solvent B is a cyclic carbonate or lactone and wherein the formulation comprises 5 to 15% m/m imidacloprid and 0.02 to 8% m/m moxidectin.
3. The method of claim 1 , wherein solvent A is present in an amount of from 50 to 90% m/m and solvent B is present in an amount of from 10 to 50% m/m of the combination of solvents A and B.
4. The method of claim 2 , wherein solvent A is present in an amount of from 50 to 90% m/m and solvent B is present in an amount of from 10 to 50% m/m of the combination of solvents A and B.
5. The method of claim 1 , wherein solvent A is benzyl alcohol and solvent B is propylene carbonate.
6. The method of claim 2 , wherein solvent A is benzyl alcohol and solvent B is propylene carbonate.
7. The method of claim 1 , wherein the spot-on formulation has a moxidectin concentration of from 0.1 to 10% m/m.
8. The method of claim 7 , wherein the spot-on formulation has a moxidectin concentration of from 0.2 to 8% m/m.
9. The method of claim 1 , wherein the spot-on formulation has a total volume of from 0.4 to 10 ml per dose.
10. The method of claim 2 , wherein the spot-on formulation has a total volume of from 0.4 to 10 ml per dose.
11. The method of claim 1 , wherein the spot-on formulation is applied to the dog at most once every four weeks for 2 to 4 months.
12. The method of claim 2 , wherein the spot-on formulation is applied to the dog at most once every four weeks for 2 to 4 months.
13. A method of treating generalized demodicosis in a dog in need thereof comprising externally applying to the dog a spot-on formulation comprising moxidectin, at most once a week.
14. The method of claim 13 , wherein the spot-on formulation has a moxidectin concentration of from 0.1 to 10% m/m.
15. The method of claim 14 , wherein the spot-on formulation has a moxidectin concentration of from 0.2 to 8% m/m.
16. The method of claim 13 , wherein the spot-on formulation has a total volume of from 0.4 to 10 ml per dose.
17. The method of claim 13 , wherein the spot-on formulation is applied to the dog at most once every four weeks for 2 to 4 months.
18. The method of claim 13 , wherein the spot-on formulation is further comprises imidacloprid.
19. The method of claim 18 , wherein the spot-on formulation comprises 5 to 15% m/m imidacloprid and 0.02 to 8% m/m moxidectin.
20. The method of claim 19 , wherein the spot-on formulation is applied to the dog at most once every four weeks for 2 to 4 months.