Ceramic composition for filling bone defects
View Patent ↗The invention is directed toward a sterile formable implant composition for application to a bone defect site comprising bioactive glass particles in an aqueous carrier solution, the bioactive glass particles being added to a viscous carrier at a concentration ranging from about 68% to about 76% (w/w), the carrier comprising a mixture of glycerol and polyethylene glycol ranging from 24% to 32% (w/w) with the ratio of glycerol to polyethylene glycol ranging from about 45:55 to about 65:35.
1. A composition for application to a bone defect site comprising bioactive glass and a carrier, wherein said bioactive glass is present in an amount ranging from about 68% to about 70% (w/w) of the composition; wherein the carrier comprises a mixture of glycerol and polyethylene glycol present in a ratio of glycerol to polyethylene glycol ranging from about 45:55 to about 65:35, wherein the carrier is present in an amount ranging from about 24% to about 32% (w/w) of the composition; and wherein the composition is malleable during application of the composition to the bone defect.
2. The composition of claim 1 , wherein said bioactive glass comprises units ranging in size from 32 microns to 710 microns.
3. The composition of claim 1 , wherein said bioactive glass comprises (a) glass particles and (b) glass powder, wherein said glass powder ranges from 32 μm to 90 μm in size.
4. The composition of claim 1 , wherein said bioactive glass comprises glass particles ranging from 90 μm to 710 μm in size and glass powder ranging from 32 μm to 90 μm in size.
5. The composition of claim 1 , wherein said bioactive glass comprises glass particles ranging from 90 μm to 710 μm in size and glass powder ranging from 32 μm to 90 μm in size, and wherein said glass particles and said glass powder are present in a ratio of glass particles to glass powder ranging from about 3.5:1 to about 5:1.
6. The composition of claim 1 , wherein said bioactive glass comprises glass particles ranging from 90 μm to 710 μm in size and glass powder ranging from 32 μm to 90 μm in size, and wherein said glass particles are present in an amount ranging from about 53% to about 62% (w/w) of the composition.
7. The composition of claim 1 , wherein said bioactive glass comprises glass particles ranging from 90 μm to 710 μm in size and glass powder ranging from 32 μm to 90 μm in size, and wherein said glass powder is present in an amount ranging from about 12% to about 19% (w/w) of the composition.
8. The composition of claim 1 , wherein said glycerol and said polyethylene glycol are present in a ratio of glycerol to polyethylene glycol of about 50:50.
9. The composition of claim 1 , further comprising a growth factor additive, wherein said growth factor additive comprises a transforming growth factor, an insulin growth factor, a platelet derived growth factor, a vascular endothelial growth factor, a fibroblast growth factor, osteopontin, a growth hormone, somatotropin, or combinations thereof.
10. The composition of claim 1 , further comprising a growth factor additive wherein said growth factor additive comprises a fibroblast growth factor, a variant thereof, or combinations thereof in an amount of 2 to 4 milligrams per 10 cc of carrier.
11. The composition of claim 1 , further comprising an antiviral additive, an antimicrobial, an antibiotic, or combinations thereof, wherein said antiviral additive comprises one or more of an antiviral additive that is effective against HIV and hepatitis, and wherein said antimicrobial or antibiotic comprises one or more of erythromycin, bacitracin, neomycin, penicillin, polymyxin B, tetracycline, viomycin, chloromycetin, streptomycin, cefazolin, ampicillin, azactam, tobramycin, clindamycin, or gentamycin.
12. The composition of claim 1 , further comprising living cells.
13. The composition of claim 12 , wherein the living cells comprise chondrocytes, platelets, blood plasma, bone marrow cells, mesenchymal stem cells, pluripotential cells, osteoblasts, fibroblasts, or combinations thereof.
14. The composition of claim 13 , wherein the living cells are present in an amount ranging from 10 5 to 10 8 per cc of the carrier.
15. The composition of claim 1 , wherein the composition is a putty.
16. A composition for application to a bone defect site comprising bioactive glass and a carrier, wherein said bioactive glass is present in an amount ranging from about 68% to about 70% (w/w) of the composition, and wherein said bioactive glass comprises glass particles ranging from 90 μm to 710 μm in size; wherein the carrier comprises a mixture of glycerol and polyethylene glycol, wherein the carrier is present in an amount ranging from about 24% to about 32% (w/w) of the composition, and wherein said glycerol and said polyethylene glycol are present in a ratio of glycerol to polyethylene glycol ranging from about 45:55 to about 65:35; and wherein the composition is malleable during application of the composition to the bone defect.
17. The composition of claim 16 , wherein the bioactive glass further comprises glass powder which ranges from 32 μm to 90 μm in size, and wherein said glass particles and said glass powder are present in a ratio of glass particles to glass powder ranging from about 3.5:1 to about 5:1.
18. The composition of claim 16 , further comprising a growth factor additive, wherein said growth factor additive comprises a transforming growth factor, an insulin growth factor, a platelet derived growth factor, a vascular endothelial growth factor, a fibroblast growth factor, osteopontin, a growth hormone, somatotropin, or combinations thereof.
19. The composition of claim 16 , further comprising a growth factor additive wherein said growth factor additive comprises a fibroblast growth factor, a variant thereof, or combinations thereof in an amount of 2 to 4 milligrams per 10 cc of carrier.
20. The composition of claim 16 , further comprising an antiviral additive, an antimicrobial, an antibiotic, or combinations thereof, wherein said antiviral additive comprises one or more of an antiviral additive that is effective against HIV and hepatitis, and wherein said antimicrobial or antibiotic comprises one or more of erythromycin, bacitracin, neomycin, penicillin, polymyxin B, tetracycline, viomycin, chloromycetin, streptomycin, cefazolin, ampicillin, azactam, tobramycin, clindamycin, or gentamycin.
21. The composition of claim 16 , further comprising living cells.
22. The composition of claim 21 , wherein the living cells comprise chondrocytes, platelets, blood plasma, bone marrow cells, mesenchymal stem cells, pluripotential cells, osteoblasts, fibroblasts, or combinations thereof.
23. The composition of claim 22 , wherein the living cells are present in an amount ranging from 10 5 to 10 8 per cc of the carrier.
24. The composition of claim 16 , wherein the composition is a putty.
25. A composition for application to a bone defect site comprising bioactive glass and a fluid carrier, wherein said bioactive glass comprises glass particles ranging from 90 μm to 710 μm in size and glass powder ranging from 32 μm to 90 μm in size, wherein said glass particles and said glass powder are present in a ratio of glass particles to glass powder ranging from about 3.5:1 to about 5:1, and wherein said bioactive glass is present in an amount ranging from about 68% to about 70% (w/w) of the composition; wherein the carrier comprises a mixture of glycerol and polyethylene glycol, wherein the carrier is present in an amount ranging from about 30% to about 32% (w/w) of the composition, and wherein said glycerol and said polyethylene glycol are present in a ratio of glycerol to polyethylene glycol ranging from about 45:55 to about 65:35; and wherein the composition is malleable during application of the composition to the bone defect.
26. The composition of claim 25 , wherein said polyethylene glycol has a molecular weight ranging from 1000 to 2000 Daltons.
27. The composition of claim 25 , further comprising living cells.
28. The composition of claim 27 , wherein the living cells comprise chondrocytes, platelets, blood plasma, bone marrow cells, mesenchymal stem cells, pluripotential cells, osteoblasts, fibroblasts, or combinations thereof.
29. The composition of claim 28 , wherein the living cells are present in an amount ranging from 10 5 to 10 8 per cc of the carrier.
30. The composition of claim 25 , wherein said composition has been sterilized by gamma radiation.
31. The composition of claim 25 , wherein the composition is a putty.