Process of reducing the bitter taste of water soluble actives by co-grinding the active with β cyclodextrin
View Patent ↗A process for reducing the intensity of the intrinsic bitter taste of a water soluble active which comprises dry mixing of said active with β-cyclodextrin.
1. A process for reducing the intensity of the intrinsic bitter taste of a water soluble active, the process comprising dry mixing of said active with β-cyclodextrin for at least one hour at <30 rpm to form an inclusion complex, wherein the degree of formation of said inclusion complex upon dry mixing is at least 50% of said active and β-cyclodextrin, as determined quantitatively by Differential Scanning calorimetry (DSC); wherein said dry mixing step is carried out by co-grinding said active and said β-cyclodextrin in a ball mill, and wherein said active is famotidine.
2. A process according to claim 1 wherein said inclusion complex comprises said active and said β-cyclodextrin in about a 1:1 molar ratio.
3. A process according to claim 1 wherein said active has a water solubility of at least 1 mg/mL.
4. The product made from a process for reducing the intensity of the intrinsic bitter taste of a water soluble active, the process comprising dry mixing of said active with β-cyclodextrin for at least one hour at <30 rpm to form an inclusion complex, wherein the degree of formation of said inclusion complex upon dry mixing is at least 50% of said active and β-cyclodextrin, as determined quantitatively by Differential Scanning Calorimetry (DSC); wherein said dry mixing step is carried out by co-grinding said active and said β-cyclodextrin in a ball mill, and wherein said active is famotidine.
5. A tablet made from the product of a process for reducing the intensity of the intrinsic bitter taste of a water soluble active, the process comprising dry mixing of said active with β-cyclodextrin for at least one hour at <30 rpm to form an inclusion complex, wherein the degree of formation of said inclusion complex upon dry mixing is at least 50% of said active and β-cyclodextrin, as determined quantitatively by Differential Scanning Calorimetry (DSC); wherein said dry mixing step is carried out by co-grinding said active and said β-cyclodextrin in a ball mill, and wherein said active is famotidine.
6. A process according to claim 1 wherein the intensity of the bitter taste of said active is reduced by at least 50%.
7. A process for reducing the intensity of the intrinsic bitter taste of doxilamine succinate, the process comprising dry mixing of the doxilamine succinate with β-cyclodextrin to form an inclusion complex.