Mesenchymal stem cells and uses therefor

1 . A method of promoting angiogenesis in an organ or tissue of an animal other than the heart, comprising:

administering to said animal mesenchymal stem cells in an amount effective to promote angiogenesis in an organ or tissue other than the heart of said animal.

2 . The method of claim 1 wherein said animal is a mammal.

3 . The method of claim 2 wherein said mammal is a primate.

4 . The method of claim 3 wherein said primate is a human.

5 . The method of claim 1 wherein said mesenchymal stem cells are administered in an amount of from about 1×10 5 cells/kg to about 1×10 7 cells/kg.

6 . The method of claim 5 wherein said mesenchymal stem cells are administered in an amount of from about 1×10 6 cells/kg to about 5×10 6 cells/kg.

7 . The method of claim 1 wherein said mesenchymal stem cells are administered systemically.

8 . The method of claim 1 wherein said mesenchymal stem cells are administered intravenously.

9 . The method of claim 1 wherein said mesenchymal stem cells are administered by direct injection to said organ or tissue other than the heart of said animal.

10 . A method of treating a disease selected from the group consisting of autoimmune diseases and graft-versus-host in an animal, comprising:

administering to said animal mesenchymal stem cells in an amount effective to treat said disease in said animal

11 . The method of claim 10 wherein said animal is a mammal

12 . The method of claim 11 wherein said mammal is a human.

13 . The method of claim 10 wherein said disease is multiple sclerosis.

14 . A method of treating an inflammatory response in an animal, comprising:

administering to said animal mesenchymal stem cells in an amount effective to treat said inflammatory response in said animal.

15 . The method of claim 14 wherein said animal is a mammal.

16 . The method of claim 15 wherein said mammal is a human.

17 . The method of claim 14 wherein said inflammatory response is associated with psoriasis.

18 . A method of treating cancer in an animal, comprising:

administering to said animal mesenchymal stem cells in an amount effective to treat cancer in said animal.

19 . The method of claim 18 wherein said animal is a mammal.

20 . The method of claim 19 wherein said mammal is a human.

21 . A method of treating an allergic disease or disorder in an animal, comprising:

administering to said animal mesenchymal stem cells in an amount effective to treat said allergic disease or disorder in said animal.

22 . The method of claim 21 wherein said animal is a mammal.

23 . The method of claim 22 wherein said mammal is a human.

24 . The method of claim 14 wherein said allergic disease or disorder is arthritis.

25 . A method of promoting wound healing in an animal, comprising:

administering to said animal mesenchymal stem cells in an amount effective to promote wound healing in said animal.

26 . The method of claim 25 wherein said animal is a mammal.

27 . The method of claim 26 wherein said mammal is a human.

28 . A method of treating or preventing a fibrotic disorder in an animal, comprising:

administering to said animal mesenchymal stem cells in an amount effective to treat or prevent said fibrotic disorder in said animal.

29 . The method of claim 28 wherein said fibrotic disorder is Acute Respiratory Distress Syndrome.

30 . The method of claim 28 wherein said fibrotic disorder is Chronic Obstructive Pulmonary Disease.

31 . The method of claim 28 wherein said fibrotic disorder is Idiopathic Pulmonary Fibrosis.

32 . A method of repairing epithelial damage in an animal, comprising:

administering to said animal mesenchymal stem cells in an amount effective to repair epithelial damage in said animal.

33 . The method of claim 32 wherein said animal is a mammal.

34 . The method of claim 33 wherein said mammal is a human.

35 . The method of claim 32 wherein said epithelial damage is a result of graft-versus-host disease.