Antifungal agents

1. A compound of Formula I:

or a pharmaceutically acceptable salt thereof, wherein:

X is O or H,H;

R 1 is

a) OH;

b) OC(O)C 1 -C 12 -alkyl, unsubstituted or substituted with 1 or 2 substituents selected from OR 0 , N(R 0 ) 2 , and CO 2 R 0 ;

c) OC(O)C 1 -C 6 -haloalkyl;

d) OC(O)C 3 -C 8 -cycloalkyl;

e) O—C 1 -C 6 -alkyl, unsubstituted or substituted with 1 or 2 substituents selected from OR 0 and N(R 0 ) 2 ;

f) OC(O)NHC 1 -C 6 -alkyl, unsubstituted or substituted with phenyl;

g) OC(O)OC 1 -C 6 -alkyl;

h) NHC(O)C 1 -C 6 -alkyl, unsubstituted or substituted with phenyl; or

i) (O) n CH 2 C(O)C 1 -C 6 -alkyl;

n is 0 or 1;

R 2 is

a) CH 2 R 4 ,

b) CH 2 CHR 5 (CH 2 ) m NR 6 R 7 ,

c) CH 2 C(R 8 )(R 9 )(CH 2 ) m NR 6 R 7 ,

d) CH 2 C(R 10 )(R 11 )R 12 ,

e) CH 2 CH(OR 0 )CH 2 OR 0 ,

f) CHR 13 CHR 5 (CH 2 ) m NR 6 R 7 ,

g) (CH 2 ) p C(R 8 )(R 9 )NR 6 R 7 , or,

h) CH 2 CHR 5 C(R 8 )(R 9 )NR 6 R 7 ,

m is 0, 1 or 2;

p is 2 to 6;

R 1 and R 2 are optionally taken together to form a methylenedioxy or ethylenedioxy, unsubstituted or substituted with 1 or 2 substituents selected from C 1 -C 6 -alkyl and C 1 -C 6 -alkoxy;

R 3 is

a) C(O)R 14 ;

b) CH 2 OH; or

c) CH 2 OC(O)C 1 -C 6 -alkyl;

R 14 is OH, OR 15 , H, N(R 0 ) 2 , or C 1 -C 6 -alkyl;

R 15 is C 1 -C 6 -alkyl, unsubstituted or substituted with 1 or 2 substituents selected from phenyl, OC(O)C 1 -C 6 -alkyl, C(O)OR 0 , OR 0 , C(O)N(R 0 ) 2 , and C(O)NH 2 (CH 2 ) 2-4 NH 2 and wherein said phenyl is optionally substituted with 1 to 3 halo groups;

R 4 is

a) H;

b) (CH 2 ) 1-6 —R 16 ;

c) OC 1 -C 6 -alkyl;

d) aryl, wherein aryl is phenyl or naphthyl and aryl is unsubstituted or substituted with 1 to 3 substituents selected from halo, N(R 0 ) 2 , OR 0 , C 1 -C 6 -alkyl, CF 3 , OCF 3 , CO 2 R 0 , and C(O)N(R 0 ) 2 ;

e) heterocyclyl, wherein heterocyclyl is a 5- or 6-membered, saturated or unsaturated non-aromatic ring having 1, 2 or 3 heteroatoms selected from N or S, at least one of which is N, attached through a carbon or nitrogen on the ring, and optionally substituted on a ring carbon or nitrogen that is not the point of attachment, with 1 to 2 substituents selected from oxo, N(R 0 ) 2 , OR 0 , CO 2 R 0 , CON(R 0 ) 2 , and C 1 -C 6 -alkyl unsubstituted or substituted with 1 or 2 substituents selected from N(R 0 ) 2 , NHC(═NH)NH 2 , OC(O)C 1 -C 6 -alkyl and CO 2 R 0 ; or

f) heteroaryl, wherein heteroaryl is a 5- or 6-membered aromatic ring having 1, 2 or 3 heteroatoms selected from N or S, at least one of which is N, attached through a ring carbon or nitrogen, and optionally substituted on a ring carbon or nitrogen that is not the point of attachment, with 1 or 2 substituents selected from N(R 0 ) 2 , OR 0 , CO 2 R 0 , CON(R 0 ) 2 , and C 1 -C 6 alkyl unsubstituted or substituted with 1 or 2 substituents selected from N(R 0 ) 2 , NHC(═NH)NH 2 , OC(O)C 1 -C 6 alkyl and CO 2 R 0 ;

R 16 is

a) H;

b) OH;

c) NH 2 ;

d) NHC(O)R 17 ;

e) NHSO 2 R 17 ;

f) NHC(O)NHR 0 ;

g) NHC(O)CHR 18 NH 2 ;

h) heterocyclyl, wherein heterocyclyl is a 5- or 6-membered, saturated or unsaturated non-aromatic ring having 1, 2 or 3 heteroatoms selected from N or S, at least one of which is N, attached through a carbon or nitrogen on the ring, and optionally substituted on a ring carbon or nitrogen that is not the point of attachment, with 1 to 2 substituents selected from N(R 0 ) 2 , imino, oxo, OR 0 , CO 2 R 0 , CON(R 0 ) 2 , and C 1 -C 6 -alkyl unsubstituted or substituted with 1 or 2 substituents selected from N(R 0 ) 2 , NHC(═NH)NH 2 , OC(O)C 1 -C 6 -alkyl, OR 0 , and CO 2 R 0 ;

i) NH—N(C 1 -C 6 -alkyl) 2 ;

j) NHC(═NH)NHC(═NH)NH 2 ;

k) NR a (CH 2 ) p NHR a ;

l) NR a R b ;

m) N(R b ) 2 ;

n) NHC(═NR d )NH 2 ;

o) NHC(═NR c )NH—C 1 -C 6 -alkyl, wherein said alkyl is unsubstituted or substituted with phenyl, CF 3 or NHC(O)C 1 -C 6 -alkyl;

p) NHC(═NR d )NH—C 3 -C 6 -cycloalkyl;

q) NHC(═NR d )NH-phenyl, wherein said phenyl is unsubstituted or substituted with 1 or 2 substituents selected from halo and CF 3 ;

r) CO 2 C 1 -C 6 -alkyl;

s) OCOC 1 -C 6 alkyl;

t) heteroaryl, wherein heteroaryl is a 5- or 6-membered aromatic ring having 1, 2 or 3 heteroatoms selected from N or S, at least one of which is N, attached through a carbon or nitrogen on the ring, and optionally substituted on a ring carbon or nitrogen that is not the point of attachment, with 1 or 2 substituents selected from N(R 0 ) 2 , OR 0 , CO 2 R 0 , CON(R 0 ) 2 , and C 1 -C 6 alkyl unsubstituted or substituted with 1 or 2 substituents selected from N(R 0 ) 2 , NHC(═NH)NH 2 , OC(O)C 1 -C 6 alkyl, OR 0 , and CO 2 R 0 ; or

u) CN;

p is 1, 2, 3 or 4;

R a is H or C(═NH)NH 2 ;

R b is C 1 -C 6 alkyl, unsubstituted or substituted with 1 or 2 substituents selected from N(R 0 ) 2 and OR 0 ;

R c is H or CN;

R d is H or C 3 -C 6 -cycloalkyl;

R 5 is

a) C 1 -C 6 -alkyl, unsubstituted or substituted with 1 or 2 substituents selected from N(R 0 ) 2 and OR 0 ;

b) OH;

c) OC 1 -C 6 -alkyl, unsubstituted or substituted with phenyl;

d) OC(O)C 1 -C 6 -alkyl;

e) C 3 -C 6 -cycloalkyl;

f) aryl, wherein aryl is phenyl or naphthyl and aryl is unsubstituted or substituted with 1 to 3 substituents selected from halo, OCF 3 , CF 3 , N(R 0 ) 2 and OR 0 ;

g) heteroaryl, wherein heteroaryl is a 5- or 6-membered aromatic ring having 1, 2 or 3 heteroatoms selected from N or S, at least one of which is N, attached through a carbon or nitrogen on the ring, and optionally substituted on a ring carbon or nitrogen that is not the point of attachment, with 1 or 2 substituents selected from N(R 0 ) 2 , OR 0 , and C 1 -C 6 -alkyl; or

h) heterocyclyl, wherein heterocyclyl is a 5- or 6-membered, saturated or unsaturated non-aromatic ring having 1, 2 or 3 heteroatoms selected from N or S, at least one of which is N, attached through a ring carbon or nitrogen, and optionally substituted on a ring carbon or nitrogen that is not the point of attachment, with 1 to 2 substituents selected from N(R 0 ) 2 , OR 0 , and C 1 -C 6 -alkyl;

R 6 is H or C 1 -C 6 -alkyl, wherein said alkyl is unsubstituted or substituted with a 5- to 6-membered saturated, unsaturated or aromatic ring having 1, 2 or 3 heteroatoms selected from N, O or S, attached through a ring carbon or nitrogen, and optionally substituted on a ring carbon or nitrogen that is not the point of attachment, with 1 to 2 substituents selected from N(R 0 ) 2 , OR 0 , CO 2 R 0 , CON(R 0 ) 2 and C 1 -C 6 -alkyl unsubstituted or substituted with one or two substituents selected from OR 0 , N(R 0 ) 2 , NHC(═NH)NH 2 , OC(O)C 1 -C 6 -alkyl, CO 2 R 0 , C(O)N(R 0 ) 2 , and NHC(O)R 0 ;

R 7 is

a) H;

b) C 1 -C 6 -alkyl, unsubstituted or substituted with 1 or 2 substituents selected from N(R 0 ) 2 , OR 0 , CO 2 R 0 , OC(O)C 1 -C 6 -alkyl, NHC(O)R 0 , C(O)N(R 0 ) 2 , phenyl, heteroaryl, and heterocyclyl, wherein heteroaryl is as defined below in (k) and heterocyclyl is as defined below in (l);

c) C(O)H;

d) C(O)C 1 -C 6 -haloalkyl;

e) C(O)C 1 -C 6 -alkyl, unsubstituted or substituted with 1 or 2 substituents selected from CO 2 R 0 , OR 0 , OCH 2 CO 2 R 0 , N(R 0 ) 2 , C(O)C 1 -C 6 -alkyl, O(CH 2 ) 2 OC 1 -C 6 -alkyl, C(O)N(R 0 ) 2 , OC(O)C 1 -C 6 alkyl, and NHC(O)R 0 ;

f) C(O)OC 1 -C 6 -alkyl;

g) C(O)NH—C 1 -C 6 -alkyl;

h) SO 2 C 1 -C 6 -alkyl;

i) C 3 -C 6 -cycloalkyl;

j) aryl, wherein aryl is phenyl or naphthyl and aryl is unsubstituted or substituted with 1 to 3 substituents selected from halo, N(R 0 ) 2 , OR 0 , C 1 -C 6 -alkyl, CF 3 , OCF 3 , CO 2 R 0 , and C(O)N(R 0 ) 2 ;

k) heteroaryl, wherein heteroaryl is a 5- or 6-membered aromatic ring having 1, 2 or 3 heteroatoms selected from N or S, at least one of which is N, attached through a carbon or nitrogen on the ring, and optionally substituted on a ring carbon or nitrogen that is not the point of attachment, with 1 or 2 substituents selected from N(R 0 ) 2 , OR 0 , CO 2 R 0 , OC(O)C 1 -C 6 -alkyl, CON(R 0) 2 , NHC(O)R 0 , and C 1 -C 6 -alkyl unsubstituted or substituted with 1 or 2 substituents selected from N(R 0 ) 2 , NHC(═NH)NH 2 , OC(O)C 1 -C 6 alkyl, OR 0 , CO 2 R 0 , C(O)N(R 0 ) 2 and NHC(O)R 0 ;

l) heterocyclyl, wherein heterocyclyl is a 5- or 6-membered, saturated or unsaturated non-aromatic ring having 1, 2 or 3 heteroatoms selected from N or S, at least one of which is N, attached through a carbon or nitrogen on the ring, and optionally substituted on a ring carbon or nitrogen that is not the point of attachment, with 1 to 2 substituents selected from N(R 0 ) 2 , imino, oxo, OR 0 , CO 2 R 0 , OC(O)C 1 -C 6 -alkyl, CON(R 0 ) 2 , NHC(O)R 0 , and C 1 -C 6 -alkyl unsubstituted or substituted with 1 or 2 substituents selected from N(R 0 ) 2 , NHC(═NH)NH 2 , OC(O)C 1 -C 6 -alkyl, OR 0 , CO 2 R 0 , C(O)N(R 0 ) 2 and NHC(O)R 0 ;

m) C(═NH)C 1 -C 6 -alkyl, wherein said alkyl is unsubstituted or substituted with 1 or 2 substituents selected from halo, CF 3 , N(R 0 ) 2 , OR 0 , and NHC(O)C 1 -C 6 -alkyl;

n) C(═NR d )NH 2 ;

o) C(═NH)NH—C 1 -C 6 -alkyl, wherein said alkyl is unsubstituted or substituted with 1 to 3 substituents selected from halo, CF 3 , N(R 0 ) 2 , OR 0 , and NHC(O)C 1 -C 6 -alkyl;

p) C(═NH)NH—C 3 -C 6 -cycloalkyl;

q) C(═NH)NH-phenyl, wherein phenyl is unsubstituted or substituted with 1 to 3 substituents selected from halo and CF 3 ; or

r) C(═NH)NHC(═NH)NH 2 ;

R 6 and R 7 are optionally taken together with the attached nitrogen atom to form a 3- to 6-membered saturated, unsaturated or aromatic ring having 0-2 additional heteroatoms selected from N, O and S, wherein said ring is optionally substituted on a ring carbon or nitrogen that is not the point of attachment, with 1 to 2 substituents selected from halo, N(R 0 ) 2 , OR 0 , CO 2 R 0 , CON(R 0 ) 2 , and C 1 -C 6 alkyl unsubstituted or substituted with 1 or 2 substituents selected from OR 0 and N(R 0 ) 2 , and wherein two adjacent substituents of said ring are optionally taken together to form a fused 5- or 6-membered saturated, unsaturated, or aromatic ring having 0-2 heteroatoms selected from N, O and S; or R 6 and R 9 are optionally taken together, with the nitrogen atom R 6 is attached to, to form a pyrrolidinyl ring;

R 8 is selected from the group consisting of

a) hydrogen,

b) C 1 -C 6 -alkyl, unsubstituted or substituted with OR 0 or SO 2 R 0 ,

c) C 3 -C 6 -cycloalkyl, and

d) aryl, wherein aryl is phenyl or naphthyl and aryl is unsubstituted or substituted with 1 to 3 substituents selected from halo, OCF 3 , CF 3 , N(R 0 ) 2 and OR 0 ;

R 9 is C 1 -C 6 -alkyl, unsubstituted or substituted with OR 0 or SO 2 R 0 ;

R 8 and R 9 are optionally taken together to form a 3- to 6-membered saturated ring having 0-1 heteroatom selected from N, O or S;

R 10 is independently selected from the group consisting of

a) C 1 -C 6 -alkyl unsubstituted or substituted with OR 0 , N(R 0 ) 2 , OC(O)C 1 -C 6 alkyl or CO 2 R 0 , and

b) CO 2 R 0 ;

R 11 is C 1 -C 6 alkyl unsubstituted or substituted with OR 0 , OC(O)C 1 -C 6 alkyl, OC(O)-phenyl, CO 2 R 0 , or N(R 0 ) 2 ;

R 12 is OH or C 1 -C 6 alkyl, wherein said alkyl is unsubstituted or substituted with OC(O)C 1 -C 6 alkyl or OR 0 ;

R 13 is C 1 -C 4 -alkyl;

R 17 is

a) C 1 -C 6 -alkyl, unsubstituted or substituted with 1 to 2 substituents selected from CO 2 R 0 , OR 0 , N(R 0 ) 2 , and OC(O)C 1 -C 6 -alkyl;

b) aryl, wherein aryl is phenyl or naphthyl and aryl is unsubstituted or substituted with 1 to 2 substituents selected from halo, OR 0 and N(R 0 ) 2 ; or

c) C 1 -C 6 -haloalkyl;

R 18 is H or C 1 -C 6 -alkyl, wherein said alkyl is unsubstituted or substituted with 1 to 2 substituents selected from OR 0 , N(R 0 ) 2 , heteroaryl, heterocyclyl, CO 2 N(R 0 ) 2 , and CO 2 R 0 , wherein heteroaryl is as defined in R 16 (t) and heterocyclyl is as defined in R 16 (h); and

each R 0 is independently H or C 1 -C 6 -alkyl.

2. The compound of claim 1 , wherein R 3 is C(O)R 14 .

3. The compound of claim 2 , wherein R 14 is OH or OR 15 .

4. The compound of claim 2 , wherein the compound is of Formula II:

5. The compound of claim 1 , wherein X is O.

6. The compound of claim 1 , wherein X is H 2 .

7. The compound of claim 1 , wherein R 1 is OC(O)C 1 -C 12 alkyl, unsubstituted or substituted with 1 or 2 substituents selected from OR 0 , N(R 0 ) 2 , and CO 2 R 0 .

8. The compound of claim 1 , wherein R 1 is OC(O)NHC 1 -C 6 alkyl, unsubstituted or substituted with phenyl.

9. The compound of claim 1 , wherein R 2 is CH 2 CHR 5 (CH 2 ) m NR 6 R 7 , CH 2 CR 8 R 9 (CH 2 ) m NR 6 R 7 , or CHR 13 CHR 5 (CH 2 ) m NR 6 R 7 .

10. The compound of claim 9 , wherein the compound is of Formula III-1, III-2, III-3 or III-4:

11. The compound of claim 9 , wherein the compound is of Formula IV-1, IV-2, IV-3 or IV-4:

12. The compound of claim 9 , wherein the compound is of Formula V-1 or Formula V-3:

13. The compound of claim 11 having Formula IV-1 wherein R 13 is —CH 3 ;

m is 0;

R 8 is selected from the group consisting of —CH 3 , CH 2 CH 3 , CH 2 OCH(CH 3 ) 2 , and CH(CH 3 ) 2;

R 9 is selected from the group consisting of CH 3 , CH 2 CH 3 , CH 2 CH 2 CH 3 , CH(CH 3 ) 2 , CH(CH 3 )(CH 2 CH 3 ), CH 2 CH 2 CH 2 CH 3 , CH 2 OCH 3 , CH 2 CH 2 OCH 3 , CH 2 CH 2 OCH 2 CH 3 , cyclohexyl, (R)CH(CH 3 ) 2 , and (S) CH(CH 3 ) 2 ;

R 6 is H, —CH 3 , CH 2 CH 3 , CH 2 CF 3 , CH 2 CH 2 CH 3 , CH 2 CH 2 OCH 3 , cyclobutyl, CH 2 -cyclopropyl, CH(CH 3 ) 2 , CH 2 CH 2 CH 2 CH 3 , CH(CH 3 )(CH 2 CH 3 ), cyclopentyl, and cyclohexyl; and

R 7 is H, —CH 3 , CH 2 CH 3 , CH(CH 3 ) 2 , and CH 2 CH 2 CH 3 .

14. The compound of claim 11 having Formula IV-1 wherein R 13 is —CH 3 , m is 0, R 8 is —CH 3 , and R 9 is —CH(CH 3 ) 2 .

15. The compound of claim 14 wherein R 6 is H or —CH 3 and R 7 is H or —CH 3 .

16. The compound of claim 15 , wherein the compound is of Formula IV-1a:

wherein R 6 is H or —CH 3 , and R 7 is H or —CH 3 .

17. The compound of claim 16 wherein R 6 is H or —CH 3 , and R 7 is —CH 3 .

18. The compound of claim 16 wherein R 6 is —CH 3 , and R 7 is —CH 3 .

19. The compound of claim 15 , wherein the compound is of Formula IV-1b:

wherein R 6 is H or —CH 3 , and R 7 is H or —CH 3 .

20. The compound of claim 19 wherein R 6 is H or —CH 3 , and R 7 is —CH 3 .

21. The compound of claim 20 wherein R 6 is —CH 3 , and R 7 is —CH 3 .

22. The compound of claim 10 , wherein m is 0.

23. The compound of claim 11 , wherein m is 0.

24. The compound of any one of claims 10 - 12 , wherein R 13 is methyl.

25. The compound of claim 23 , wherein both R 8 and R 9 are C 1 -C 3 alkyl; or R 8 and R 9 are taken together to form a 3- to 6-membered saturated ring having 0-1 heteroatom selected from N, O or S.

26. The compound of claim 25 , wherein R 8 is methyl and R 9 is methyl, ethyl or propyl; or R 8 and R 9 are taken together to form a cyclobutyl.

27. The compound of claim 23 or 25 , wherein both R 6 and R 7 are H.

28. The compound of claim 23 or 25 , wherein R 6 and R 7 are independently unsubstituted C 1 -C 6 -alkyl.

29. The compound of claim 28 , wherein R 6 and R 7 are independently methyl or ethyl, or R 6 is H and R 7 is propyl.

30. The compound of claim 10 or 12 , wherein m is 1.

31. The compound of claim 11 , wherein m is 1.

32. The compound of claim 1 selected from the group consisting of:

(1S,2R,3R,4aR,6aS,7R,8R,10aR,10bR,12aR)-3-(acetyloxy)-2-[(2S)-2-amino-2,3-dimethylbutyloxy]-8-[(1R)-1,2-dimethyl propyl]-1,6a,8,10a-tetramethyl-6-oxo-1,3,4,6,6a,7,8,9,10,10a,10b,11,12,12a-tetradecahydro-2H-1,4a-(methanooxymethano)chrysene-7-carboxylic acid,

(1S,2R,3R,4aR,6aS,7R,8R,10aR,10bR,12aR)-3-(acetyloxy)-2-[(2S)-2-methylamino-2,3-dimethylbutyloxy]-8-[(1R)-1,2-dimethyl propyl]-1,6a,8,10a-tetramethyl-6-oxo-1,3,4,6,6a,7,8,9,10,10a,10b,11,12,12a-tetradecahydro-2H-1,4a-(methanooxymethano)chrysene-7-carboxylic acid,

(1S,2R,3R,4aR,6aS,7R,8R,10aR,10bR,12aR)-3-(acetyloxy)-2-[(2S)-2-dimethylamino-2,3-dimethylbutyloxy]-8-[(1R)-1,2-dimethyl propyl]-1,6a,8,10a-tetramethyl-6-oxo-1,3,4,6,6a,7,8,9,10,10a,10b,11,12,12a-tetradecahydro-2H-1,4a-(methanooxymethano)chrysene-7-carboxylic acid,

(1S,2R,3R,4aR,6aS,7R,8R,10aR,10bR,12aR)-3-acetoxy-2-[[(2R)-2-amino-2,3-dimethylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-1,6a,8,10a-tetramethyl-6-oxo-1,3,4,6,6a,7,8,9,10,10a,10b,11,12,12a-tetradecahydro-2H-1,4a-(methanooxymethano)chrysene-7-carboxylic acid,

(1S,2R,3R,4aR,6aS,7R,8R,10aR,10bR,12aR)-3-acetoxy-2-[[(2R)-2-methylamino-2,3-dimethylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-1,6a,8,10a-tetramethyl-6-oxo-1,3,4,6,6a,7,8,9,10,10a,10b,11,12,12a-tetradecahydro-2H-1,4a-(methanooxymethano)chrysene-7-carboxylic acid, and

(1S,2R,3R,4aR,6aS,7R,8R,10aR,10bR,12aR)-3-acetoxy-2-[[(2R)-2-dimethylamino-2,3-dimethylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-1,6a,8,10a-tetramethyl-6-oxo-1,3,4,6,6a,7,8,9,10,10a,10b,11,12,12a-tetradecahydro-2H-1,4a-(methanooxymethano)chrysene-7-carboxylic acid,

and pharmaceutically acceptable salts thereof.

33. A compound of claim 32 which is:

(1S,2R,3R,4aR,6aS,7R,8R,10aR,10bR,12aR)-3-(acetyloxy)-2-[(2S)-2-dimethylamino-2,3-dimethylbutyloxy]-8-[(1R)-1,2-dimethyl propyl]-1,6a,8,10a-tetramethyl-6-oxo-1,3,4,6,6a,7,8,9,10,10a,10b,11,12,12a-tetradecahydro-2H-1,4a-(methanooxymethano)chrysene-7-carboxylic acid

or a pharmaceutically acceptable salt thereof.

34. The compound of claim 1 , wherein the compound is selected from Tables A-H and J-M and 3a.

35. A composition comprising a compound of claim 1 and a carrier, adjuvant, or vehicle.

36. The method of treating a fungal infection in a mammal, comprising administering to said mammal an effective amount of a compound of claim 1 .

37. The method of claim 36 , wherein said fungal infection is caused by Cryptococcus spp., Candida spp, or Aspergillus spp, fungi.

38. A compound of claim 32 which is:

(1S,2R,3R,4aR,6aS,7R,8R,10aR,10bR,12aR)-3-(acetyloxy)-2-[(2S)-2-methylamino-2,3-dimethylbutyloxy]-8-[(1R)-1,2-dimethyl propyl]-1,6a,8,10a-tetramethyl-6-oxo-1,3,4,6,6a,7,8,9,10,10a,10b,11,12,12a-tetradecahydro-2H-1,4a-(methanooxymethano)chrysene-7-carboxylic acid or a pharmaceutically acceptable salt thereof.