Substituted dihydroquinazolines
View Patent ↗The invention relates to substituted dihydroquinazolines and to processes for their preparation and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular for use as antiviral agents, in particular against cytomegalo viruses.
1. A compound of formula (I):
in which
R 1 represents hydrogen or methoxy;
R 3 represents halogen or trifluoromethyl; and
R represents halogen or methoxy;
or a salt thereof.
2. The compound of claim 1 , wherein R 3 represents fluorine, chlorine or trifluoromethyl; or a salt thereof.
3. The compound of claim 1 , wherein R represents fluorine, chlorine or methoxy; or a salt thereof.
4. The compound of claim 1 , wherein R is attached to the phenyl ring via the position meta or para to the point of attachment of the phenyl ring; or a salt thereof.
5. A compound {8-Fluoro-2-[4-(3-methoxyphenyl)piperazin-1-yl]-3-(2-methoxy-5-trifluoromethylphenyl)-3,4-dihydroquinazolin-4-yl}acetic acid, or a salt thereof.
6. A compound (S)-{8-Fluoro-2-[4-(3-methoxyphenyl)piperazin-1-yl]-3-(2-methoxy-5-trifluoromethylphenyl)-3,4-dihydroquinazolin-4-yl}acetic acid, or a salt thereof.
7. A process for preparing a compound of formula (I) according to claim 1 , wherein a compound of formula (II):
in which
R 1 , R 3 and R are as defined in claims 1 ; and
R 4 represents alkyl;
is reacted with an acid or a base.
8. The process of claim 7 , wherein R 4 is methyl, ethyl or tert-butyl.
9. A medicament comprising a compound of claim 1 , a compound of claim 5 , or a compound of claim 6 in combination with at least one inert, non toxic, pharmaceutically acceptable excipient.
10. A method for the production of a medicament for the treatment of viral infections, comprising mixing a compound of claim 1 , a compound of claim 5 , or a compound of claim 6 with at least one inert, non toxic, pharmaceutically acceptable excipient.
11. The method of claim 10 , wherein the viral infection is an infection with the human cytomegalovirus (HCMV) or another representative of the group of the Herpes viridae.
12. A method for treating infections HO—C(═O)—CH 2 — at the 4-position; in humans and animals, comprising administering an antivirally effective amount of a compound of claim 1 , a compound of claim 5 , or a compound of claim 6 , to a human or animal in need thereof.
13. A method for treating infections HO—C(═O)—CH 2 — at the 4-position; in humans and animals, comprising administering an antivirally effective amount of a medicament of claim 9 to a human or animal in need thereof.