Computational methods and systems to reinforce a humoral immune response

1 . A method, comprising:

designating one or more computable epitopes of at least one agent;

predicting one or more changes in the one or more computable epitopes of the at least one agent; and

aiding the identification of one or more immune response components associated with the one or more computable epitopes of the at least one agent.

2 . The method of claim 1 , wherein the designating one or more computable epitopes of at least one agent further comprises:

designating one or more computable epitopes of at least nine nucleotides.

3 . The method of claim 1 , wherein the designating one or more computable epitopes of at least one agent further comprises:

designating at least a portion of at least one of a nucleotide, a carbohydrate, a lipid, a polysaccharide, a lipopolysaccharide, a glycolipid, a glycoprotein, and/or a polyglycopeptide.

4 . The method of claim 1 , wherein the designating one or more computable epitopes of at least one agent further comprises:

designating one or more computable epitopes of a substantially non-linear form.

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9 . The method of claim 1 , wherein the predicting one or more changes in the one or more computable epitopes of the at least one agent further comprises:

designating the one or more computable epitopes having a substantially similar functional sequence match with at least one host.

10 . The method of claim 1 , wherein the predicting one or more changes in the one or more computable epitopes of the at least one agent further comprises:

designating the one or more computable epitopes having a substantially similar structural match with at least one host.

11 . The method of claim 1 , wherein the aiding the identification of one or more immune response components associated with the one or more computable epitopes of the at least one agent further comprises:

providing one or more predicted courses of an immune response in a host and wherein the one or more predicted courses are responsive to one or more interventions.

12 . The method of claim 1 , wherein the aiding the identification of one or more immune response components associated with the one or more computable epitopes of the at least one agent includes:

aiding the identification of at least a part of one or more of a T-lymphocyte, a killer T-lymphocyte, a helper T-lymphocyte, a cytotoxic T-lymphocyte, a T-8 lymphocyte, a Cluster of Differentiation (CD) molecule, a CD3 molecule, or a CD1 molecule.

13 . The method of claim 1 , wherein the aiding the identification of one or more immune response components associated with the one or more computable epitopes of the at least one agent includes:

aiding the identification of at least a part of at least one B-lymphocyte.

14 . The method of claim 1 , wherein the aiding the identification of one or more immune response components associated with the one or more computable epitopes of the at least one agent includes:

aiding the identification of at least one modulator of at least a part of a B-lymphocyte.

15 . The method of claim 1 , wherein the aiding the identification of one or more immune response components associated with the one or more computable epitopes of the at least one agent includes:

aiding the identification of one or more of a modulator of at least a part of at least one of a T-lymphocyte, a killer T-lymphocyte, a helper T-lymphocyte, a cytotoxic T-lymphocyte, a T-8 lymphocyte, a Cluster of Differentiation (CD) molecule, a CD3 molecule, or a CD1 molecule.

16 . The method of claim 1 , wherein the aiding the identification of one or more immune response components associated with the one or more computable epitopes of the at least one agent includes:

aiding the identification of at least a part of one or more of a humanized antibody.

17 . The method of claim 1 , wherein the aiding the identification of one or more immune response components associated with the one or more computable epitopes of the at least one agent includes:

aiding the identification of one or more of a modulator of at least a part of at least one of a humanized antibody.

18 . The method of claim 1 , wherein the aiding the identification of one or more immune response components associated with the one or more computable epitopes of the at least one agent includes:

aiding the identification of one or more immune response components directed to at least one of a glycoprotein, and/or a receptor ligand.

19 . The method of claim 1 , wherein the aiding the identification of one or more immune response components associated with the one or more computable epitopes of the at least one agent includes:

aiding the identification of at least one modulator of (a) an epitopic shift or (b) an epitopic drift predicted in the at least one agent.

20 . The method of claim 19 , wherein the at least one modulator of (a) an epitopic shift or (b) an epitopic drift predicted in the at least one agent, further comprises:

aiding the identification of at least one suppressor of mutational alteration of the at least one agent.

21 . The method of claim 19 , wherein the at least one modulator of (a) an epitopic shift or (b) an epitopic drift predicted in the at least one agent, further comprises:

aiding the identification of at least one interfering nucleic acid or nucleic acid sequence.

22 . A method, comprising:

identifying an association of at least a computable portion of one or more agents with at least a part of an immune response;

projecting a pattern of one or more changes relating to the at least a computable portion of the one or more agents; and

selecting one or more immune response components in response to the projecting.

23 . The method of claim 22 , wherein the selecting one or more immune response components further comprises:

selecting at least a part of one or more of a T-lymphocyte, a killer T-lymphocyte, a helper T-lymphocyte, a cytotoxic T-lymphocyte, a T-8 lymphocyte, a Cluster of Differentiation (CD) molecule, a CD3 molecule, or a CD1 molecule.

24 . The method of claim 22 , wherein the selecting one or more immune response components further comprises:

selecting one or more modulators of at least a part of at least one of a T-lymphocyte, a killer T-lymphocyte, a helper T-lymphocyte, a cytotoxic T-lymphocyte, a T-8 lymphocyte, a Cluster of Differentiation (CD) molecule, a CD3 molecule, or a CD1 molecule.

25 . The method of claim 22 , wherein the selecting one or more immune response components further comprises:

selecting at least a part of at least one B-lymphocyte.

26 . The method of claim 22 , wherein the selecting one or more immune response components further comprises:

selecting one or more modulators of at least a part of at least one B-lymphocyte.

27 . The method of claim 22 , wherein the selecting one or more immune response components further comprises:

selecting at least a part of one or more humanized antibody.

28 . The method of claim 22 , wherein the selecting one or more immune response components further comprises:

selecting one or more of a modulator of at least a part of at least one humanized antibody.

29 . The method of claim 22 , wherein the identifying an association of at least a computable portion of one or more agents with at least a part of an immune response further comprises:

identifying an association of at least a computable portion of at least one of a polyglycopeptide, a polysaccharide, a nucleic acid, or a toxin.

30 . A system, comprising:

circuitry for identifying an association of at least a computable portion of one or more agents with at least a part of an immune response;

circuitry for projecting a pattern of one or more changes relating to the at least a computable portion of the one or more agents; and

circuitry for selecting one or more immune response components in response to said circuitry for projecting.

31 . The system of claim 30 , wherein the circuitry for selecting one or more immune response components further comprises:

circuitry for selecting at least a part of one or more of a T-lymphocyte, a killer T-lymphocyte, a helper T-lymphocyte, a cytotoxic T-lymphocyte, a T-8 lymphocyte, a Cluster of Differentiation (CD) molecule, a CD3 molecule, or a CD1 molecule.

32 . The system of claim 30 , wherein the circuitry for selecting one or more immune response components further comprises:

circuitry for selecting one or more modulators of at least a part of at least one of a T-lymphocyte, a killer T-lymphocyte, a helper T-lymphocyte, a cytotoxic T-lymphocyte, a T-8 lymphocyte, a Cluster of Differentiation (CD) molecule, a CD3 molecule, or a CD1 molecule.

33 . The system of claim 30 , wherein the circuitry for selecting one or more immune response components further comprises:

circuitry for selecting at least a part of at least one B-lymphocyte.

34 . The system of claim 30 , wherein the circuitry for selecting one or more immune response components further comprises:

circuitry for selecting one or more modulators of at least a part of at least one B-lymphocyte.

35 . The system of claim 30 , wherein the circuitry for selecting one or more immune response components further comprises:

circuitry for selecting at least a part of one or more humanized antibody.

36 . The system of claim 30 , wherein the circuitry for selecting one or more immune response components further comprises:

circuitry for selecting one or more modulators of at least a part of at least one humanized antibody.

37 . The system of claim 30 , wherein the circuitry for identifying an association of at least a computable portion of one or more agents with at least a part of an immune response further comprises:

circuitry for identifying an association of at least a portion of at least one of a polyglycopeptide, a polysaccharide, a nucleic acid, or a toxin.

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40 . A method, comprising:

identifying an association of at least one computable epitope of one or more agents with at least a part of an immune response;

projecting a pattern of one or more changes relating to the at least one computable epitope of the one or more agents; and

selecting one or more immune response components in response to the projecting.

41 . The method of claim 40 , wherein the selecting one or more immune response components further comprises:

selecting at least a part of one or more of a T-lymphocyte, a killer T-lymphocyte, a helper T-lymphocyte, a cytotoxic T-lymphocyte, a T-8 lymphocyte, a Cluster of Differentiation (CD) molecule, a CD3 molecule, or a CD1 molecule.

42 . The method of claim 40 , wherein the selecting one or more immune response components further comprises:

selecting one or more modulators of at least a part of at least one of a T-lymphocyte, a killer T-lymphocyte, a helper T-lymphocyte, a cytotoxic T-lymphocyte, a T-8 lymphocyte, a Cluster of Differentiation (CD) molecule, a CD3 molecule, or a CD1 molecule.

43 . The method of claim 40 , wherein the selecting one or more immune response components further comprises:

selecting at least a part of at least one B-lymphocyte.

44 . The method of claim 40 , wherein the selecting one or more immune response components further comprises:

selecting one or more modulators of at least a part of at least one B-lymphocyte.

45 . The method of claim 40 , wherein the selecting one or more immune response components further comprises:

selecting at least a part of one or more humanized antibody.

46 . The method of claim 40 , wherein the selecting one or more immune response components further comprises:

selecting one or more modulators of at least a part of at least one humanized antibody.

47 . The method of claim 40 , wherein the identifying an association of at least one computable epitope of one or more agents with a part of an immune response further comprises:

identifying an association of at least one computable epitope of at least one of a polyglycopeptide, a polysaccharide, a nucleic acid, or a toxin.

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