IP Library › Granted Patent US 7,648,986
Granted Patent B2
US 7,648,986 · App. 11/733,045 · Granted Jan 19, 2010

Substituted thieno[3,2-D]pyrimidines as Rho kinase inhibitors

View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 7,648,986
App. No.
11/733,045
Granted
Jan 19, 2010
Kind
B2
Abstract

Disclosed are compounds and derivatives thereof their synthesis, and their use as Rho-kinase inhibitors. These compounds of the present invention are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.

Claims (14)

1. A compound of the formula

wherein Ar 1 is

or a pharmaceutically acceptable salt thereof.

2. A compound of the formula

or a pharmaceutically acceptable salt thereof.

3. A compound of the formula

wherein Ar is

3-aminophenyl, 3-isonicotinamido-phenyl, 5-(1H-indolyl)amino, or 4-phenoxyanilino.

4. A compound of the formula

or a pharmaceutically acceptable salt thereof.

5. A method of treating hypertension, atherosclerosis, restenosis, cerebral ischemia, cerebral vasospasm, erectile dysfunction, comprising administering to host in need thereof a compound according to claim 4 .

6. A method of treating hypertension, atherosclerosis, restenosis, cerebral ischemia, cerebral vasospasm, or erectile dysfunction, comprising administering to a host in need thereof a compound according to claim 1 .

7. A method according to claim 5 , wherein the host is a human.

8. A method according to claim 6 , wherein the host is a human.