Angiogenin complexes (ANGex) and uses thereof
Stabilized angiogenin compositions and methods of preparing a stabilized angiogenin compositions by non-covalent immobilization on a naturally occurring substrate, such as a protein, lipid, nucleic acid or nucleotide substrate, are disclosed.
1. A composition comprising isolated angiogenin non-covalently complexed to an isolated naturally occurring substrate comprising lactoferrin.
2. The composition of claim 1 , wherein the angiogenin is isolated from a biological fluid.
3. The composition of claim 2 , wherein the biological fluid is selected from the group consisting of colostrum, milk, whey, milk serum, blood, plasma and serum.
4. The composition of claim 2 , wherein the biological fluid is obtained from a mammal and wherein the mammal is selected from the group consisting of humans, cows, buffalos, horses, sheep, pigs and camels.
5. A method of preparing angiogenin complexes comprising mixing angiogenin with a substrate comprising lactoferrin in a liquid medium.
6. The method of claim 5 , wherein the liquid medium is water.