Prevention of quantum dot quenching on metal surfaces
View Patent ↗A formulation comprises quantum dots and a quenching-preventive agent in a carrier material. The quenching-preventive agent is a metal chelating agents, a corrosion inhibitor, or a combination thereof. The formulation can be applied to a metal substrate, without experiencing metal ion induced fluorescence quenching.
1. A formulation comprising:
a plurality of quantum dots selected from CdSe/ZnS and CdSeTe/ZnS; and
a metal chelating agent including (ethylenedinitrilo)tetraacetic acid (EDTA); and
a carrier material comprising water:methanol (1:1), polyacrylate and polyurethane.
2. The formulation of claim 1 wherein the metal chelating agent is present in the formulation at about from 1 mM to about 50 mM.
3. The formulation of claim 1 wherein the metal chelating agent is present in the formulation at about from 5 mM to about 15 mM.
4. The formulation of claim 1 wherein the quantum dots are further conjugated to a biomolecule.
5. The formulation of claim 4 wherein the biomolecule is protein or peptide.
6. The formulation of claim 1 wherein the quantum dots are present in the formulation at about 1 nM-500 nM.
7. The formulation of claim 1 wherein the quantum dots are present in the formulation at about 1 nM-100 nM.
8. The formulation of claim 1 wherein the quantum dots are present in the formulation at about 20 nM-50 nM.
9. The formulation of claim 1 further comprising a corrosion inhibitor.
10. The formulation of claim 9 wherein the corrosion inhibitor is present in the formulation at about 1 mM-50 mM.
11. The formulation of claim 9 wherein the corrosion inhibitor is present in the formulation at about 5 mM-20 mM.
12. The formulation of claim 9 wherein the corrosion inhibitor is benzotriazole, dithiothiadiazole, 2-aminopyrimidine, 5,6-dimethylbenzimidazole, 2-amino-5-mercapto-1,3,4-thiadiazole, 2-mercaptopyrimidine, 2-mercaptobenzoxazole, 2-mercaptobenzothiazole, or 2-mercaptobenzimidazole.
13. The formulation of claim 1 further comprising benzotriazole.