Enhancement of lens regeneration using materials comprising polysiloxane polymers
View Patent ↗The present invention addresses the treatment of ocular conditions by the enhancement of lens regeneration. Enhancement of lens regeneration is accomplished by the administration of a composition comprising a polysiloxane polymer having functional acryl groups useful in the preparation of intraocular lenses (IOLs).
1. A kit for enhancing regeneration of lens cells in a mammal after endocapsular extraction, comprising (i) an injectable polysiloxane polymer lens material having a backbone of general formula:
wherein R 1 and R 2 are independently C 1 -C 6 alkyl; R 3 is phenyl; R 4 is phenyl or C 1 -C 6 alkyl; R 5 is CF 3 (CH 2 ) x , wherein x is 1-5; R 6 is C 1 -C 6 alkyl or fluoroalkyl; 1 is in the molar fraction range of 0 to 0.95; m is in the molar fraction range of from greater than 0 to 0.7; and n is in the molar fraction range of from greater than 0 to 0.65, (ii) a visoelastic material which is a cross-linked hyaluronic acid and (iii) hyaluronidase.
2. A kit according to claim 1 wherein said polysiloxane polymer is photocurable.
3. A kit according to claim 1 wherein said kit further comprises a collagen patch.
4. A kit according to claim 1 wherein said kit further comprises an intraocular lens.
5. A kit according to claim 1 wherein said kit further comprises a contact lens polymeric material in the form of a permeable or semi-permeable disc shaped lens.