Stabilization method of reduced coenzyme Q
View Patent ↗The present invention provides a method for stabilizing reduced coenzyme Q 10 , which is useful as a food, nutritional product, nutritional supplement, animal drug, drink, feed, cosmetic, pharmaceutical product, therapeutic drug, prophylactic drug and the like. The present invention also provides a method of producing a reduced coenzyme Q 10 -containing composition which includes the co-presence of reduced coenzyme Q 10 and reduced coenzyme Q 9 and/or reduced coenzyme Q 11 .
1. A method for stabilizing reduced coenzyme Q 10 , which method comprises preparing a reduced coenzyme Q 10 -containing composition comprising reduced coenzyme Q 10 and one or both of (a) and (b):
(a) not less than 1.5 wt % to not more than 99 wt % of reduced coenzyme Q 9 relative to reduced coenzyme Q 10 , and
(b) reduced coenzyme Q 11 ,
wherein not less than 0.01 wt % of reduced coenzyme Q 10 is contained in the composition, and
wherein the proportion of reduced coenzyme Q 10 relative to the total amount of coenzyme Q 10 is not less than 90 wt %,
thereby stabilizing reduced coenzyme Q 10 .
2. The method of claim 1 , wherein the method comprises
preparing one or both of (a) the reduced coenzyme Q 9 and (b) the reduced coenzyme Q 11 , and then
adding one or both of (a) the reduced coenzyme Q 9 and (b) the reduced coenzyme Q 11 to the reduced coenzyme Q 10 to prepare the reduced coenzyme Q 10 -containing composition.
3. The method of claim 1 , wherein the method comprises
providing a composition comprising oxidized coenzyme Q 10 with one or both of oxidized coenzyme Q 9 and oxidized coenzyme Q 11 , and then
reducing oxidized coenzyme Q 10 and reducing one or both of oxidized coenzyme Q 9 and oxidized coenzyme Q 11 to prepare the reduced coenzyme Q 10 -containing composition.
4. The method of claim 1 , wherein the reduced coenzyme Q 10 -containing composition is prepared under a deoxygenation atmosphere.
5. A reduced coenzyme Q 10 -containing composition comprising reduced coenzyme Q 10 and one or both of (a) and (b):
(a) not less than 1.5 wt % to not more than 99 wt % of reduced coenzyme Q 9 relative to reduced coenzyme Q 10 , and
(b) reduced coenzyme Q 11
wherein not less than 0.01 wt % of reduced coenzyme Q 10 is contained in the composition, and
wherein the proportion of reduced coenzyme Q 10 relative to the total amount of coenzyme Q 10 is not less than 90 wt %.
6. The composition of claim 5 , wherein the reduced coenzyme Q 10 is in crystalline form.
7. The composition of claim 5 , wherein the reduced coenzyme Q 10 is dissolved or suspended in a solvent.
8. The composition of claim 5 , wherein the reduced coenzyme Q 10 is a melt.
9. The composition of claim 5 , which further comprises a pharmaceutically acceptable carrier.
10. The composition of claim 5 , which is in a form suitable for administration to a mammal and comprises reduced coenzyme Q 10 as an active ingredient.
11. The composition of claim 5 , which further comprises at least one component selected from the group consisting of an excipient, a disintegrant, a lubricant, a binder, an antioxidant, a coloring agent, an anticoagulant, an absorption promoter, a solubilizing agent for the active ingredient, a stabilizer, an active ingredient other than reduced coenzyme Q 10 , and combinations thereof.
12. An oral dosage form comprising the composition of claim 11 , which dosage form is a capsule.
13. The oral dosage form of claim 12 , wherein the capsule is a microcapsule, a soft capsule, or a hard capsule.
14. A method for producing a reduced coenzyme Q 10 -containing composition, which method comprises
preparing one or both of (a) reduced coenzyme Q 9 and (b) reduced coenzyme Q 11 , and then
adding one or both of (a) the reduced coenzyme Q 9 and (b) the reduced coenzyme Q 11 to reduced coenzyme Q 10 to prepare the reduced coenzyme Q 10 -containing composition,
wherein the composition comprises reduced coenzyme Q 10 and one or both of (a) not less than 1.5 wt % to not more than 99 wt % of reduced coenzyme Q 9 relative to reduced coenzyme Q 10 and (b) reduced coenzyme Q 11 ,
wherein not less than 0.01 wt % of reduced coenzyme Q 10 is contained in the composition, and
wherein the proportion of reduced coenzyme Q 10 relative to the total amount of coenzyme Q 10 is not less than 90 wt %.
15. A method for producing a reduced coenzyme Q 10 -containing composition, which method comprises
providing a composition comprising oxidized coenzyme Q 10 with one or both of oxidized coenzyme Q 9 and oxidized coenzyme Q 11 , and then
reducing oxidized coenzyme Q 10 and reducing one or both of oxidized coenzyme Q 9 and oxidized coenzyme Q 11 to prepare the reduced coenzyme Q 10 -containing composition,
wherein the composition comprises reduced coenzyme Q 10 and one or both of (a) not less than 1.5 wt % to not more than 99 wt % of reduced coenzyme Q 9 relative to reduced coenzyme Q 10 and (b) reduced coenzyme Q 11 ,
wherein not less than 0.01 wt % of reduced coenzyme Q 10 is contained in the composition, and
wherein the proportion of reduced coenzyme Q 10 relative to the total amount of coenzyme Q 10 is not less than 90 wt %.
16. The composition of claim 5 , wherein the reduced coenzyme Q 10 -containing composition comprises not less than 1.5 wt % to not more than 99 wt % of reduced coenzyme Q 9 relative to reduced coenzyme Q 10 .
17. The composition of claim 5 , wherein the reduced coenzyme Q 10 -containing composition comprises reduced coenzyme Q 11 .
18. The composition of claim 5 , wherein the reduced coenzyme Q 10 -containing composition comprises not less than 96 wt % of reduced coenzyme Q 10 relative to the total amount of coenzyme Q 10 .