IP Library Granted Patent US 7,468,195
Granted Patent B2
US 7,468,195 · App. 11/744,731 · Granted Dec 23, 2008

Skin treatment preparation

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Quick Facts
Patent No.
US 7,468,195
App. No.
11/744,731
Granted
Dec 23, 2008
Kind
B2
Abstract

A skin treatment preparation including carriers, a medicinal vector encapsulating a plant extract (Cucumis melo protein extract) rich in reductase, catalase and superoxide dismutase is characterized in that the medicinal vector, of nanospheres, represents 1 to 20 wt. % of the weight of the preparation; and the encapsulated plant extract represents 5 to 15 wt. % of the weight of the nanospheres; and the encapsulated plant extract may have the following enzymatic concentrations: reductase between 100 and 1000 IU, catalase between 100 and 1000 IU, and superoxide dismutase between 500 and 5000 IU. The preparation is useful for limiting depigmentation and reducing inflammatory front in vilitigo pathology and possible repigmentation.

Claims (25)

1. A skin treatment preparation, comprising excipients and a medicinal vector encapsulating a Cucumis melo protein extract rich in reductase, catalase and superoxide dismutase, wherein:

the medicinal vector consists of nanospheres and represents between 1% and 20% of the weight of the preparation; and

the nanospheres in the form of spherical particles encapsulating the Cucumis melo protein extract have a membrane made of collagen and glycosaminoglycan, wherein a load of the Cucumis melo protein extract of the nanospheres is from 5 to 15 weight percent of the nanospheres.

2. The skin treatment preparation according to claim 1 , wherein the Cucumis melo protein extract has the following enzyme concentrations:

reductase: between 100 RI and 1000RI;

catalase: between 100 IU and 1000 IU; and

superoxide dismutase: between 500 IU and 5000 IU.

3. The skin treatment preparation according to claim 1 , wherein the excipients contain a mixture of oils, fatty acids, antioxidants and preservatives.

4. A skin treatment preparation comprising excipients and medicinal vectors encapsulating a Cucumis melo protein extract rich in reductase, catalase and superoxide dismutase according to claim 1 , wherein the skin treatment preparation contains, per hundred parts:

1 to 20% of nanospheres encapsulating the Cucumis melo protein extract;

b 1 % of preservative;

0.1% of an ion-chelating agent;

0.3% of a gelling agent based on modified cellulose;

0.6% of an agent for adjusting the pH; and

the remainder up to 100% consisting of demineralized water and a mixture of excipients commonly used for a skin application.

5. The skin treatment preparation according to claim 4 , wherein the skin treatment preparation contains 3% of nanospheres encapsulating the Cucumis melo protein extract.

6. A method for treating vitiligo in skin of a human, the method including:

providing a skin treatment preparation, wherein the skin preparation comprises excipients, a medicinal vector encapsulating a plant extract rich in reductase, catalase and superoxide dismutase, wherein the medicinal vector consists of nanospheres and represents between 1 and 20 weight percent of the skin preparation, and wherein the nanospheres in a form of spherical particles encapsulating the plant extract have a membrane made of collagen and glycosaminoglycan; and

applying the skin treatment preparation to the skin of the human having vitiligo 1 wherein a load of the Cucumis melo protein extract of the nanospheres is from 5 to 15 weight percent of the nanospheres.

7. The method according to claim 6 , wherein the excipients contain a mixture of oils, and fatty acids, antioxidants and preservatives.

8. The method according to claim 6 , wherein the plant extract has the following enzyme concentrations:

reductase: between 100 IU and 1000 RI;

catalase: between 100 IU and 1000 IU; and

superoxide dismutase: between 500 IU and 5000 IU.

9. The method according to claim 6 , wherein the plant extract is a Cucumis melo protein extract.

Assignments (6)
CHANGE OF NAME Recorded Jan 11, 2011
From: A.C.M. CRAWFORD
To: ACM
Reel/Frame 025616/0198 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 10, 2011
From: CRAWFORD HEALTHCARE LIMITED
To: A.C.M. CRAWFORD
Reel/Frame 025604/0265 →
RELEASE OF SECURITY INTEREST Recorded Jan 6, 2011
From: FORTRESS CREDIT CO. LLC
To: CRAWFORD HEALTHCARE LIMITED
Reel/Frame 025592/0250 →
PATENT COLLATERAL ASSIGNMENT AND SECURITY AGREEMENT Recorded Apr 3, 2009
From: YORK PHARMA PLC
To: ULURU INC.
Reel/Frame 022494/0457 →
SECURITY INTEREST Recorded Oct 28, 2008
From: CRAWFORD HEALTHCARE LIMITED
To: FORTRESS CREDIT CO. LLC
Reel/Frame 021753/0469 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 7, 2007
From: DIEHL, CHRISTIAN
To: CRAWFORD HEALTHCARE LIMITED
Reel/Frame 019405/0579 →