HDL for the treatment of stroke and other ischemic conditions
View Patent ↗The present invention relates to a method for the prophylaxis and/or treatment of stroke and other ischemic injury, wherein HDL is administered to a subject in need thereof, particularly by intravenous infusion.
1. A method for treatment of ischemia or reperfusion injury comprising administering to a subject in need thereof an effective amount of HDL.
2. The method of claim 1 wherein the ischemia or reperfusion injury is selected from the group consisting of ischemic stroke, ischemic tissue injury, cardiac ischemia, and cardiac reperfusion injury.
3. The method of claim 1 wherein HDL is administered by intravenous infusion and/or injection.
4. The method of claim 1 wherein HDL is administered before the start of ischemia and/or during ischemia.
5. The method of claim 1 wherein HDL is administered at or after reperfusion.
6. The method of claim 1 wherein HDL is administered in a dosage of from 10-200 mg HDL (weight based on apolipoprotein) per kg body weight per treatment.
7. The method of claim 1 wherein HDL is administered as a bolus injection and/or as an infusion.
8. The method of claim 1 wherein the HDL has a molar ratio of protein to phospholipid in the range of 1:50-1:250 and optionally additional lipids present in a molar ratio of protein to additional lipid of up to 1:20.
9. The method of claim 1 , wherein HDL is administered in combination with other pharmaceutical agents.
10. The method of claim 1 , wherein the HDL is selected from nascent HDL, reconstituted HDL (rHDL), recombinant HDL or mixtures thereof.
11. The method of claim 1 , wherein the subject is a human.
12. The method of claim 1 wherein the HDL is administered after an ischemic event.
13. A method for reducing injury resulting from ischemia or reperfusion comprising administering an effective amount of HDL to a subject prior to an ischemic or reperfusion event.