IP Library Granted Patent US 7,482,383
Granted Patent B2
US 7,482,383 · App. 11/748,304 · Granted Jan 27, 2009

Emulsion containing a plant extract, method for producing said emulsion and for obtaining said plant extract

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Quick Facts
Patent No.
US 7,482,383
App. No.
11/748,304
Granted
Jan 27, 2009
Kind
B2
Abstract

The invention provides a continuous process for obtaining triterpenes from plants and/or their components. The process can include continuously washing at least one of plant and plant parts in counter-current at 20° C. to 70° C. with a solvent in which the triterpenes are not soluble or only slightly soluble and continuously extracting triterpenes from the washed plant part or parts with a solvent under an increased pressure and an elevated temperature relative to the washing pressure and temperature in counter-current to form a triterpene containing solution where the plant parts are conveyed in counter-current to the solvent flow, on the basis of their different density in a pressure-tight and heatable tube and are discharged at an end of the tube opposite to the solvent discharge. The process can also include the steps of continuously cooling and depressurizing the triterpene containing solution, where triterpene crystallizes out of the solvent, filtering the triterpene crystals from the solvent at room temperature and washing the triterpene crystals in fresh solvent.

Claims (60)

1. An emulsion, comprising:

an aqueous phase;

a fatty phase; and

water;

wherein the aqueous phase and the fatty phase are emulsified using a plant extract,

wherein the plant extract is at least one triterpene, or at least one derivate of a triterpene;

wherein the fatty phase contains at least one oil and/or fat;

wherein the triterpene and/or its derivative is the only emulsifier and preservative in the emulsion;

wherein the proportion of triterpene and/or its derivative comprises 2 to 10% of the total weight of the emulsion.

2. The emulsion according to claim 1 , wherein the plant extract is a birch bark extract.

3. The emulsion according to claim 2 , wherein the emulsion comprises 2 to 10% birch bark extract, 20 to 30% avocado oil, 10 to 20% almond oil, 5 to 10% moisturizing agent and 30 to 63% water.

4. An emulsion according to claim 3 , wherein the emulsion comprises 4% birch bark extract, 29.3% avocado oil, 14.7% almond oil, 5% glycerin and/or 5% urea and from 42 to 47% water.

5. The emulsion according to claim 1 , wherein the emulsion further includes at least one moisturizing agent and/or at least one thickening agent.

6. The emulsion according to claim 5 , wherein the thickening agent is a polysaccharide, which is added in a concentration of 0.2 to 2%, preferably 0.5%, based upon the amount of water.

7. The emulsion according to claim 6 , wherein the polysaccharide is agar agar or carrageenan.

8. The emulsion according to claim 5 , wherein the moisturizing agent is glycerin and/or urea, which is added in a concentration of 3 to 10%, preferably 5% of each, based upon the amount of the emulsion.

9. The emulsion according to claim 1 , wherein the triterpene comprises betulin and, optionally, is at least one substance selected from the group consisting of betulinic acid, lupeol, erythrodiol, allobetulin, phellonic acid, hydroxy-lactone, betulin aldyhyde, β-amyrin, oleanolic acid, ursolic acid, esterified betulin and/or β-sitosteol.

10. The emulsion according to claim 1 , thereby characterized, that the proportion of triterpene and/or it derivative comprises 2 to 3.5% or 3.5 to 10% of the total weight of the emulsion.

11. An emulsion according to claim 1 , wherein the plant extract comprises at least 80% betulin, at most 10% betulinic acid, at most 3% lupeol and at most 4% oleanolic acid.

12. An emulsion, comprising:

an aqueous phase;

a fatty phase; and

water;

wherein the aqueous phase and the fatty phase are emulsified using a plant extract,

wherein the plant extract is at least one triterpene, or at least one derivate of a triterpene;

wherein the fatty phase contains at least one oil and/or fat;

said emulsion excluding any emulsifier other than the triterpene and/or it derivative; and wherein the emulsion includes 2 to 10% plant extract, 20 to 30% avocado oil, 10 to 20% almond oil and 40 to 68% water.

13. The emulsion according to claim 12 , wherein the emulsion comprises 4% plant extract, 29.3% avocado oil, 14.7% almond oil and 52% water.

14. An emulsion comprising:

an aqueous phase;

a fatty phase; and

water;

wherein the aqueous phase and the fatty phase are emulsified using a plant extract,

wherein the plant extract is at least one triterpene or at least one derivate of a triterpene;

wherein said emulsion includes a preservative, an emulsifier and an pharmaceutical active substance;

said preservative consisting of the triterpene or at least one derivate of a triterpene;

said emulsifier consisting of the triterpene or at least one derivate of a triterpene;

said active substance consisting of the triterpene or at least one derivate of a triterpene, said emulsion excluding any emulsifier other than the triterpene and/or a derivative thereof; and wherein the proportion of triterpene and/or its derivative comprises approximately 2% to approximately 10% of the total weight of the emulsion.

15. An emulsion, comprising:

an aqueous phase;

a fatty phase; and

water;

wherein the aqueous phase and the fatty phase are emulsified using a plant extract,

wherein the plant extract is at least one triterpene, or at least one derivate of a triterpene;

wherein the fatty phase contains at least one oil and/or fat;

wherein the triterpene and/or its derivative is the only emulsifier and preservative in the emulsion;

wherein the emulsion further includes at least one moisturizing agent;

and wherein the moisturizing agent is glycerin and/or urea, which is added in a concentration of 3 to 10%, preferably 5% of each, based upon the amount of the emulsion.

16. The emulsion according to claim 15 , wherein the proportion of triterpene and/or its derivative comprises 2 to 10% of the total weight of the emulsion.

17. An emulsion, comprising:

an aqueous phase;

a fatty phase; and

water;

wherein the aqueous phase and the fatty phase are emulsified using a plant extract,

wherein the plant extract is at least one triterpene, or at least one derivate of a triterpene;

wherein the fatty phase contains at least one oil and/or fat;

wherein the triterpene and/or its derivative is the only emulsifier and preservative in the emulsion;

wherein the emulsion further includes at least one thickening agent; and

wherein the thickening agent is a polysaccharide, which is added in a concentration of 0.2 to 2%, preferably 0.5%, based upon the amount of water.

18. The emulsion according to claim 17 , wherein the proportion of triterpene and/or its derivative comprises 2 to 10% of the total weight of the emulsion.

Assignments (4)
MERGER Recorded Jan 12, 2024
From: AMRYT RESEARCH LIMITED
To: AMRYT PHARMACEUTICALS DESIGNATED ACTIVITY COMPANY
Reel/Frame 066110/0568 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 24, 2016
From: BIRKEN AG
To: AMRYT RESEARCH LIMITED
Reel/Frame 038700/0466 →
CHANGE OF NAME Recorded Nov 24, 2015
From: BIRKEN GMBH
To: BIRKEN AG
Reel/Frame 037132/0051 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 6, 2007
From: SCHEFFLER, ARMIN
To: BIRKEN GMBH
Reel/Frame 019648/0539 →