Hydrogel Materials
The present invention relates to biocompatible crosslinked biomaterials made from polycondensation polymerization reactions involving polynucleophilic-polyelectrophilic precursors that address the limitations of steric hindrance, viscosity, and diffusion currently reducing gelation rates and curing thoroughness of the biomaterials. A cross-linking scheme is utilized in the invention that permits rapid gelation and thorough curing of the biomaterial. The biomaterial is made by polycondensation polymerization of polynucleophilic-polyelectrophilic precursors to form a water-soluble polymer crosslinked with a water-soluble crosslinker having at most one core cyclic structure.
1 . A hydrogel material comprising:
at least one water-soluble polymer cross-linked with a water-soluble crosslinker; and
wherein the crosslinker is an organic molecule with one core cyclic structure, two or more linking groups attached to the core cyclic structure, and one or more functional groups attached to each linking group.
2 . The hydrogel material of claim 1 wherein said water-soluble polymer is synthetic.
3 . The hydrogel material of claim 1 wherein said cyclic crosslinker has a molecular weight less than 10,000 Daltons.
4 . The hydrogel material of claim 1 wherein said cyclic crosslinker has a molecular weight less than 7,500 Daltons.
5 . The hydrogel material of claim 1 wherein said cyclic crosslinker has a molecular weight less than 6,000 Daltons.
6 . The hydrogel material of claim 1 wherein said cyclic crosslinker has a molecular weight less than 5,000 Daltons.
7 . A hydrogel material comprising:
at least one synthetic water-soluble polymer cross-linked with a water-soluble crosslinker;
wherein the crosslinker is an organic molecule with one core cyclic structure, two or more linking groups attached to the core cyclic structure, and one or more functional groups attached to each linking group; and
wherein the crosslinker has a molecular weight of less than 10,000 Daltons.
8 . The hydrogel material of claim 7 wherein said cyclic crosslinker has a molecular weight less than 7,500 Daltons.
9 . The hydrogel material of claim 7 wherein said cyclic crosslinker has a molecular weight less than 6,000 Daltons.
10 . The hydrogel material of claim 7 wherein said cyclic crosslinker has a molecular weight less than 5,000 Daltons.
11 . A method of making a hydrogel material comprising:
providing at least one synthetic water-soluble polymer;
providing a crosslinker in the form of an organic molecule with a molecular weight less than 10,000 Daltons, wherein said organic molecule has one core cyclic structure, two or more linking groups attached to the core cyclic structure, and one or more functional groups attached to each linking group; and
admixing said at least one synthetic water-soluble polymer with said crosslinker.
12 . The hydrogel material of claim 11 wherein said cyclic crosslinker has a molecular weight less than 7,500 Daltons.
13 . The hydrogel material of claim 11 wherein said cyclic crosslinker has a molecular weight less than 6,000 Daltons.
14 . The hydrogel material of claim 11 wherein said cyclic crosslinker has a molecular weight less than 5,000 Daltons.
15 . A hydrogel material made according to the method of claim 11 .
16 . A hydrogel material made according to the method of claim 12 .
17 . A hydrogel material made according to the method of claim 13 .
18 . A hydrogel material made according to the method of claim 13 .
19 . A hydrogel material made by polycondensation polymerization of polynucleophilic-polyelectrophilic precursors to form a water-soluble polymer crosslinked with a water-soluble cyclic crosslinker, wherein the crosslinker is an organic molecule having a molecular weight less than 10,000 Daltons, one core cyclic structure, two or more linking groups attached to the core cyclic structure, and one or more functional groups attached to each linking group.
20 . The hydrogel material of claim 19 wherein said water-soluble polymer is synthetic.
21 . The hydrogel material of claim 19 wherein said water-soluble cyclic cross-linker is synthetic.