Compositions and methods for enhancing brain function
View Patent ↗Compositions and methods are provided that enhance cognition in a human to which the composition is orally administered. Remarkably, clinical studies have proven that contemplated compositions achieve the desired effects using a minimal number of active ingredients at or near threshold active dosages, wherein such compositions almost exclusively comprise huperzine A, vinpocetine, and acetyl-L-carnitine at typically less than 1600 mg per daily dosage.
1. A method of assisting enhancement of cognitive function in a person using a nutritional supplement, comprising:
providing a composition that includes huperzine A, vinpocetine, and acetyl-L-carnitine in a ratio of x:y:z, wherein x is between 0.8 and 1.2, y is between 80 and 120, and z is between 8,000 and 12,000, and further providing an optional additional ingredient;
formulating the supplement for oral administration such that the huperzine A, vinpocetine, and acetyl-L-carnitine together account for at least 80 wt % of a dosage unit of the supplement; and
obtaining data in a clinical trial that establishes that the quantities and ratios of huperzine A, vinpocetine, and acetyl-L-carnitine in the supplement are effective to improve cognitive function.
2. The method of claim 1 wherein x is between 0.9 and 1.1, y is between 90 and 110, and z is between 9,000 and 11,000.
3. The method of claim 1 wherein at least one of (a) huperzine A is present in the first component an amount of about 150 mcg, (b) vinpocetine is present in the first component an amount of about 15 mg, and (c) acetyl-L-carnitine is present in the first component an amount of about 1,500 mg.
4. The method of claim 1 wherein the supplement is formulated with an enteric coating.
5. The method of claim 1 wherein the additional ingredient is an inactive ingredient selected from the group consisting of a carrier, a binder, an excipient, and a dye.
6. The method of claim 1 wherein the huperzine A, vinpocetine, and acetyl-L-carnitine together account for at least 90 wt % of a dosage unit of the supplement.
7. The method of claim 1 wherein the dosage unit of the supplement is equal or less than 1,600 mg.
8. The method of claim 1 wherein the cognitive function is a function of working memory, a function of long term memory consolidation, an aspect of mood, a function of fluid intelligence, spatial memory, and object working memory.
9. The method of claim 1 further comprising a step of providing an interactive tool that allows at least one of validation of efficacy of the supplement and proper personal dosing of the supplement.