Nomogram computation and application system and method for refractive laser surgery
View Patent ↗A method for optimizing a prescription for laser-ablation corneal treatment includes receiving a measured correction prescription for a current patient. Next a database of treatment outcomes on a plurality of previously treated patients is accessed. The database contains a desired correction, and an actual correction. A difference between the desired correction and the actual correction represents an over- or undercorrection resulting from surgery. From the difference data is calculated a distribution of data points as a function of correction level. From the data-point distribution is calculated a statistically based offset applicable to the correction prescription for matching actual corrections with desired corrections. From the data-point distribution is calculated a confidence interval of the data using a predetermined confidence level. The statistically based offset is then adjusted based upon the confidence interval to provide an optimized prescription. The adjusted offset is then output for use in performing a refractive procedure.
1. A method for optimizing a prescription for laser-ablation corneal treatment comprising the steps of:
receiving a current measured correction prescription for a current patient;
accessing a database of treatment outcomes on a plurality of previously treated patients, each treatment outcome comprising a desired correction based upon a measured correction prescription and a postoperative actual correction of a previously treated patient;
calculating, by a processor, from the treatment outcomes in the database a distribution of data points as a function of correction level;
calculating, by the processor, from the data point distribution a slope and a statistically based offset using a regression analysis that characterizes the data point distribution, the slope and offset corresponding to a trend line;
calculating, by the processor, from the data point distribution a confidence interval of the data points relative to the trend line using a predetermined confidence level;
calculating, by the processor, from the slope and the offset of the data point distribution a compensation value used to adjust the current measured correction prescription, the compensation value adjusting the current measured correction prescription to a greater extent if there is a smaller confidence interval to a lesser extent if there is a larger confidence interval; and
outputting the compensation value for use in performing a refractive procedure.
2. The method recited in claim 1 , wherein the step of calculating a statistically based offset comprises performing a least-squares fit to calculate the offset.
3. The method recited in claim 1 , wherein the step of calculating a statistically based offset comprises performing a minimum least-squares error fit to calculate the offset.
4. The method recited in claim 1 , wherein the predetermined confidence level is in a range of 90 to 95%.
5. A system for optimizing a prescription for laser-ablation corneal treatment comprising:
a processor;
a database of treatment outcomes on a plurality of previously treated patients, each treatment outcome comprising a desired correction based upon a measured correction prescription and a postoperative actual correction of a previously treated patient, the database in signal communication with the processor;
a software package resident on a medium readable by the processor, the software package comprising code segments adapted to:
receive a current measured correction prescription for a current patient;
access the database of treatment outcomes;
calculate, by a processor, from the accessed treatment outcomes a distribution of data points as a function of correction level;
calculate, by the processor, from the data point distribution a slope and a statistically based offset using a regression analysis that characterizes the data point distribution, the slope and offset corresponding to a trend line;
calculate, by the processor, from the data point distribution a confidence interval of the data points relative to the trend line using a predetermined confidence level;
calculate, by the processor, from the slope and the offset of the data point distribution a compensation value used to adjust the current measured correction prescription, the compensation value adjusting current measured correction prescription to a greater extent if there is a smaller confidence interval and to a lesser extent if there is a larger confidence interval; and
output the compensation value for use in performing a refractive procedure.
6. The system recited in claim 5 , wherein the code segment for calculating a statistically based offset comprises a code segment for performing a least-squares fit to calculate the offset.
7. The system recited in claim 5 , wherein the code segment for calculating a statistically based offset comprises a code segment for performing a minimum least-squares error fit to calculate the offset.
8. The system recited in claim 5 , wherein the predetermined confidence level is in a range of 90 to 95%.
9. A method for performing a refractive procedure on a patient comprising the steps of:
measuring a current patient to determine a current correction needed to achieve a desired vision improvement, the current correction achievable with a refractive procedure;
accessing a database of treatment outcomes on a plurality of previously treated patients, each treatment outcome comprising a desired correction based upon a measured correction prescription and a postoperative actual correction of a previously treated patient;
calculating, by a processor, from the treatment outcomes in the database a distribution of data points as a function of correction level;
calculating, by the processor, from the data point distribution a slope and a statistically based offset using a regression analysis that characterizes the data point distribution, the slope and offset corresponding to a trend line;
calculating, by the processor, from the data point distribution a confidence interval of the data points relative to the trend line using a predetermined confidence level;
calculating, by the processor, from the slope and the offset of the data point distribution a compensation value used to adjust the current correction, the compensation value adjusting the current correction to a greater extent if there is a smaller confidence interval and to a lesser extent if there is a larger confidence interval; and
performing the refractive procedure on the current patient using the compensation value.
10. The method recited in claim 9 , wherein the step of calculating a statistically based offset comprises performing a least-squares fit to calculate the offset.
11. The method recited in claim 9 , where the step of calculating a statistically based offset comprises performing a minimum least-squares error fit to calculate the offset.
12. The method recited in claim 9 , where the predetermined confidence level is in a range of 90 to 95%.
13. A method comprising:
accessing a database of a plurality of treatment outcomes of a plurality of previously treated patients, wherein each treatment outcome comprises a desired correction prescription and a postoperative actual correction of a previously treated patient;
calculating, by a processor, from the treatment outcomes in the database a distribution of data points as a function of correction level;
performing a regression analysis to characterize the distribution of data points and to determine a trend line;
calculating, by the processor, from the regression analysis a confidence interval of the distribution of data points relative to the trend line according to a predetermined confidence level;
calculating, by the processor, from the regression analysis an offset and a slope;
calculating, by the processor, from the slope and the offset of the data point distribution a compensation value used to adjust a new desired correction prescription, the compensation value adjusting the new desired correction prescription to a greater extent if there is a smaller confidence interval and to a lesser extent if there is a larger confidence interval; and
outputting the compensation value for use in determining a refractive procedure.
14. The method recited in claim 13 , further comprising:
adjusting the new desired correction prescription using the compensation value;
obtaining a new postoperative actual correction resulting from the new desired correction prescription; and
adding the new desired correction prescription and the new postoperative actual correction into the database as a new treatment outcome.
15. The method recited in claim 13 , wherein calculating the compensation value further comprises:
reducing the compensation value based on the confidence interval.
16. The method recited in claim 13 , wherein calculating the compensation value further comprises:
if the confidence interval is smaller than a predetermined amount, calculating the compensation value from the slope and the offset; and
if the confidence interval is larger than a predetermined amount, calculating the compensation value from the slope and the offset and reducing the calculated compensation value.
17. The method recited in claim 13 , wherein the predetermined confidence level is in a range of 90 to 95%.