IP Library › Granted Patent US 8,388,955
Granted Patent B2
US 8,388,955 · App. 11/764,001 · Granted Mar 5, 2013

Fc variants

Inventors: Gregory Alan Lazar (Los Angeles, CA); Wei Dang (Pasadena, CA); John R. Desjarlais (Pasadena, CA); Sher Bahadur Karki (Pasadena, CA); Omid Vafa (Monrovia, CA); Robert Hayes (Paoli, PA); Jost Vielmetter (Altadena, CA)
Assignee: Xencor, Inc.
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 8,388,955
App. No.
11/764,001
Granted
Mar 5, 2013
Kind
B2
Abstract

The present invention relates to Fc variants having increased affinity for FcγRIIb, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants.

Claims (4)

1. A method of mediating antibody-dependent cell-mediated cytotoxicity (ADCC) in a human comprising administering to a human a composition comprising a variant antibody of a parent antibody, wherein said variant comprises 239D/332E substitutions in the Fc region, wherein numbering is according to the EU index.

2. The method according to claim 1 , wherein said parent antibody is selected from the group consisting of a human antibody, a humanized antibody, and a monoclonal antibody.

3. The method according to claim 1 or 2 , wherein said antibody comprises an IgG 1 region.

4. The method according to claim 1 or 2 , wherein said variant antibody has specificity for a target antigen selected from the group consisting ofAIpha5beta1 integrin, CDI9, CD20, CD22, CD30, CD33, CD40, CD40L, CD52, Her2/neu, EGFR, EpCAM, MUCI, GD3, CEA, CA 125, HLA-DR, TNFalpha, MUCI8 prostate specific membrane antigen (PMSA) and VEGF.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 13, 2014
From: VIELMETTER, JOST
To: XENCOR, INC.
Reel/Frame 032883/0120 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 13, 2014
From: LAZAR, GREGORY ALAN; DANG, WEI; DESJARLAIS, JOHN R.; KARKI, SHER BAHADUR; VAFA, OMID; HAYES, ROBERT
To: XENCOR, INC.
Reel/Frame 032883/0123 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 13, 2014
From: LAZAR, GREGORY ALAN; DESJARLAIS, JOHN RUDOLF; MARSHALL, SHANNON ALICIA; DAHIYAT, BASSIL I.
To: XENCOR, INC.
Reel/Frame 032883/0140 →
Continuity (10)
Division 11124620 · May 5, 2005
Continuation In Part 10822231 · Mar 26, 2004
Continuation In Part 10672280 · Sep 26, 2003
Continuation In Part 10379392 · Mar 3, 2003
Provisional Application 60568440 · May 5, 2004
Provisional Application 60589906 · Jul 20, 2004
Provisional Application 60627026 · Nov 9, 2004
Provisional Application 60627774 · Nov 12, 2004
Provisional Application 60626991 · Nov 10, 2004
Related Publication 20070231329A1 · Oct 4, 2007