IP Library Granted Patent US 8,021,696
Granted Patent B2
US 8,021,696 · App. 11/765,587 · Granted Sep 20, 2011

Anti-inflammatory dissolvable film

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Quick Facts
Patent No.
US 8,021,696
App. No.
11/765,587
Granted
Sep 20, 2011
Kind
B2
Abstract

Provided, among other things, is a slowly dissolvable film comprising: herbal bioactive agent(s); and polymer(s), dissolvable in the aggregate, wherein the film becomes adhesive as it is placed against a mucosal surface and begins to absorb moisture therefrom.

Claims (21)

1. A dissolvable film comprising:

a) an antiinflammatory amount of an extract of Sambucus nigra and one or more of a second extract of Allium sativum, Camellia sinensis, Centella asiatica, Commiphora molmol, Echinacea purpurea, Gaultheria procumbens, Hypericum perforatum, Krameria triandra, Ligusticum porterii-osha, Matricaria recutita, Melissa officinalis, Salix alba, Thymus vulgaris, Uncaria tomentosa, Usnea barbata or Vaccinium myrtillus;

b) an adhesive layer comprising:

50% or more by weight polymer(s) comprising an adhesion-promoting amount of carbamer and one or more soluble polymers,

wherein the adhesive layer becomes adhesive as it is placed against a mucosal surface and begins to absorb moisture therefrom, and the adhesion of the adhesive layer is less aggressive than would pertain for an adhesive layer consisting of polymers including 40% or more by weight of Carbopol 940 and said antiinflammatory amount of said extracts,

and wherein the extracts are substantially comprised in the adhesive layer; and

c) a less adhesive protective layer, wherein the protective layer has components selected to be, on the whole, relatively less dissolvable than those of adhesive layer;

wherein the film, when placed on an oral mucosal surface, dissolves away completely after 15 minutes or more and dissolution is such that such film can be applied to an oral mucosal lesion two or more times per day without film removal from the lesion,

wherein the film has only the two layers,

and wherein the film, if periodically applied to an aphthous or trauma-related ulcer, is effective in ameliorating such ulcer.

2. The film of claim 1 , comprising tear lines to aid a user to tear out a piece that is shaped or sized more appropriately for an intended administration site.

3. The film of claim 1 , wherein said extracts of Sambucus nigra comprises 51 to 100% by weight of the extracts in the film.

4. The film of claim 3 , wherein the second extract comprises from 1 to 50% by weight of extracts agent(s) in the film.

5. The film of claim 1 , further comprising one or more non-herbal anti-inflammatory agents.

6. A method of treating an oral condition comprising orally administering the film according to claim 1 , wherein said oral condition is selected from the group consisting of aphthous ulceration, mucosal lesion secondary to chemotherapy, mucosal legion secondary to radiation treatment and gingivitis.

7. The film of claim 1 , wherein the film comprises an antiinflammatory effective amount of component(s) of Sambucus nigra and Calendula officinalis.

8. The film of claim 1 , wherein the film comprises an antiinflammatory effective amount of component(s) of Sambucus nigra, Calendula officinalis and Centella asiatica.

9. The film of claim 1 , wherein the film comprises a gingivitis-treating effective amount of said extracts.

10. The film of claim 1 , wherein the film comprises a aphthous ulceration-treating effective amount of said extracts.

11. The film of claim 1 , wherein the film comprises an amount of said extracts effective to treat lesions secondary to chemotherapy or radiation treatment.

12. The film of claim 1 , wherein the film comprises an amount of said extracts effective to treat mucositis secondary to chemotherapy or radiation treatment.

Assignments (6)
RELEASE OF SECURITY INTEREST Recorded May 19, 2025
From: IZUN PHARMACEUTICALS CORPORATION
To: KALMAN, JONATHAN, MR.
Reel/Frame 071152/0608 →
SECURITY INTEREST Recorded Jun 30, 2021
From: IZUN PHARMACEUTICALS CORPORATION
To: JONATHAN KALMAN
Reel/Frame 056716/0583 →
RELEASE OF SECURITY INTEREST Recorded Jan 8, 2019
From: IZUN PHARMACEUTICALS CORPORATION
To: HAHN, ELLIOT F
Reel/Frame 047934/0363 →
CORRECTIVE ASSIGNMENT TO CORRECT THE APPLICATION NUMBERS 14193345 AND 15006421 PREVIOUSLY RECORDED AT REEL: 040824 FRAME: 0202. ASSIGNOR(S) HEREBY CONFIRMS THE SECURITY AGREEMENT. Recorded Dec 28, 2017
From: IZUN PHARMACEUTICALS CORPORATION
To: HAHN, ELLIOT F
Reel/Frame 045032/0099 →
SECURITY AGREEMENT Recorded Dec 6, 2016
From: IZUN PHARMACEUTICALS CORPORATION
To: HAHN, ELLIOT F
Reel/Frame 040824/0202 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 12, 2008
From: LOEWY, ZVI G.; LEVINE, WILLIAM Z.; SAFFER, ARON J.
To: IZUN PHARMACEUTICALS CORPORATION
Reel/Frame 021375/0347 →