Curing accelerator and method of making
A sterilized cyanoacrylate adhesive composition including a cyanoacrylate composition and a cure speed enhancer, wherein the sterilized cyanoacrylate adhesive composition does not cure upon sterilization. A kit for applying the sterilized cyanoacrylate adhesive composition, including the cyanoacrylate adhesive composition and an applicator. A method of making the sterilized cyanoacrylate adhesive composition, by adding a cure speed enhancer to a cyanoacrylate adhesive composition and sterilizing the composition. A method of applying the sterilized cyanoacrylate adhesive composition to tissue by applying the sterilized cyanoacrylate adhesive composition as a liquid, and quickly curing the sterilized cyanoacrylate adhesive composition. A method of sealing tissue by applying the sterilized cyanoacrylate adhesive composition as a liquid to tissue to be sealed, quickly curing the sterilized cyanoacrylate adhesive composition, and sealing the tissue.
1. A sterilized cyanoacrylate adhesive composition, comprising
99% or more by weight, based on the weight of the adhesive composition, of 2-octyl cyanoacrylate, mixed together with
butylated hydroxyl anisole,
sulfur dioxide, and
100 to 1000 parts per million, based on the weight of the adhesive composition, of a 18-crown-6 crown ether,
wherein the composition is sterilized by irradiation, and wherein the sterilized composition has a viscosity of 5 to 70 cp following storage for twelve days at 80° C.
2. The sterilized cyanoacrylate adhesive composition of claim 1 , wherein the sterilized composition has a viscosity of 5 to 30 cp following storage for twelve days at 80° C.
3. The sterilized cyanoacrylate adhesive composition of claim 1 , wherein the composition has been treated with a particulate agent chosen from the group consisting of vinyl pyrrolidone polymers and co-polymers to reduce the amount of contaminants in the composition.
4. The sterilized cyanoacrylate adhesive composition of claim 1 , further comprising therapeutic-loaded nanoparticles.
5. A kit, comprising the sterilized cyanoacrylate adhesive composition of claim 1 and an applicator.
6. The kit of claim 5 , wherein said sterilized cyanoacrylate adhesive composition has a viscosity of 5 to 30 cp following storage for twelve days at 80° C.
7. The kit of claim 5 , wherein said cyanoacrylate adhesive composition has been treated with a particulate agent chosen from the group consisting of vinyl pyrrolidone polymers and co-polymers to reduce the amount of contaminants in the composition.
8. The kit of claim 5 , wherein said cyanoacrylate adhesive composition further comprises therapeutic-loaded nanoparticles.
9. A method of making the sterilized cyanoacrylate adhesive composition of claim 1 , comprising
mixing 99% or more by weight, based on the weight of the adhesive composition, of 2-octyl cyanoacrylate with butylated hydroxyl anisole, sulfur dioxide, and 100 to 1000 parts per million, based on the weight of the adhesive composition, of a 18-crown-6 crown ether to form a cyanoacrylate adhesive composition, and
sterilizing the composition by irradiating the composition,
wherein the sterilized composition has a viscosity of 5 to 70 cp following storage for twelve days at 80° C.
10. The method of claim 9 , further comprising mixing therapeutic-loaded nanoparticles together with the cyanoacrylate adhesive composition.
11. The method of claim 9 , wherein said sterilizing comprises irradiating the composition with gamma irradiation, electron beam irradiation, microwave irradiation, or ultraviolet radiation.
12. A method of sealing tissue, comprising applying the sterilized cyanoacrylate adhesive composition of claim 1 to a tissue to be sealed thereby sealing the tissue.
13. The sterilized cyanoacrylate adhesive composition of claim 1 , wherein the sulfur dioxide is present in the composition at a concentration of less than 20 parts per million.