Thiazoline and oxazoline derivatives and their methods of use
View Patent ↗The invention relates to a series of thiazoline and oxazoline derivatives, compositions thereof, and methods of treating conditions and disorders using such compounds.
1. A compound of formula (I):
or a pharmaceutically acceptable salt, ester, or amide thereof, wherein
n is 1;
R 1 is hydrogen or alkyl;
R 2 is alkyl, wherein the alkyl group is substituted with 1, 2, or 3 hydroxyl groups;
L is C(O);
X is S; and
Z is heterocycle.
2. The compound of claim 1 , wherein
Z is a heterocycle represented by the formula R k R l N—, wherein R k and l taken
together with the nitrogen atom to which each is attached form a monocyclic heterocycle, a bicyclic heterocycle, a monocyclic heteroaryl, or a bicyclic heteroaryl, wherein each group is substituted with 0, 1, 2, or 3 substituents selected from halo, hydroxyl, aryl, and heteroaryl.
3. The compound of claim 2 , wherein
Z is unsubstituted pyrrolidine or pyrrolidine substituted with halo.
4. The compound of claim 3 , wherein halo is fluoro.
5. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein the compound is N-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-(hydroxymethyl)-1,3-thiazol-2(3H)-ylidene]pyrrolidine-1-carboxamide.
6. A pharmaceutical composition comprising a therapeutically effective amount of the compound of claim 1 in combination with a pharmaceutically acceptable carrier.