Pyrrole derivatives and their methods of use

1. A compound of the formula (I):

or a pharmaceutically acceptable salt, ester, amide thereof, wherein:

A is a 6-membered aryl ring;

R 1 is —SO 2 R 10 ;

R 2 is hydrogen or alkyl;

R 3 is —C(O)R 12 ;

R 4 is aryl substituted with 0, 1, 2, 3, 4, or 5 substituents independently elected from acyl, acyloxy, alkenyl, alkoxyalkoxy, alkoxyalkyl, alkoxycarbonyl, alkoxyimino, alkoxysulfonyl, alkyl, alkylcarbonyl, alkylsulfonyl, alkynyl, amino, carboxy, cyano, cyanoalkyl, formyl, haloalkoxy, haloalkyl, halo, hydroxy, hydroxyalkyl, mercapto, nitro, thioalkoxy, —NR A R B , (NR A R B ) alkyl, (NR A R B )alkoxy, (NR A R B )carbonyl, and (NR A R B )sulfonyl, wherein R A and R B are independently selected from hydrogen, alkyl, alkylcarbonyl, alkylsulfonyl, and formyl, or —R 14 R 15 ;

R 5 is hydrogen, halo, aryl, heteroaryl, bicyclic heteroaryl, —R 23 —R 24 , or —R 23 —C(O)—R 24 ;

R 10 is NR 11a R 11b ;

R 11a and R 11b are independently hydrogen or alkyl; or R 11a and R 11b taken together with the nitrogen atom to which each is attached form a 4-, 5-, or 6-membered heterocycle;

R 12 is hydrogen, alkyl, heterocycle, heteroarylalkyl, or —NR 16 R 17 ,

R 14 is aryl;

R 15 is aryl, heteroaryl, heterocycle or

R 16 and R 17 are independently hydrogen, alkyl, alkoxy, alkoxyalkyl, aryl, arylalkyl, cycloalkyl, heteroaryl, heteroarylalkyl, heterocycle, heterocyclealkyl, hydroxyalkyl or R 18 R 19 N-alkyl-;

R 18 and R 19 are independently hydrogen or alkyl;

R 21 is aryl or heteroaryl;

R 22 is arylalkyl;

R 23 is aryl; and

R 24 is heteroaryl or heterocycle.

2. The compound of claim 1 , wherein

A is phenyl; and

R 2 is alkyl.

3. The compound of claim 1 , wherein

A is phenyl; and

R 2 is methyl.

4. The compound of claim 1 , wherein

A is phenyl;

R 2 is methyl; and

R 1 is —SO 2 NH 2 .

5. The compound of claim 1 , wherein

A is phenyl;

R 2 is methyl;

R 1 is —SO 2 NH 2 ;

R 4 is aryl, wherein aryl is optionally substituted with 1, 2, or 3 selected from the group consisting of alkyl, alkylcarbonyl, alkylsulfonyl, cyano, halo, haloalkyl, nitro, —NR A R B , where in R A and R B are independently hydrogen, alkyl, alkylcarbonyl and alkylsulfonyl.

6. A pharmaceutical composition comprising a compound of claim 1 and a pharmaceutically acceptable carrier.

7. The compound of claim 1 , wherein the compound is selected from the group consisting of:

5-(4-chloro-phenyl)-1-[4-(dimethylaminomethylene-sulfamoyl)-phenyl]-2-methyl-1H-pyrrole-3-carboxylic acid N-methoxy-N-methyl amide;

4-[5-(4-chloro-phenyl)-2-methyl-3-propionyl-pyrrol-1yl]-benzenesulfonamide;

4-[5-(4-chloro-phenyl)-3-isobutyryl-2-methyl-pyrrol-1yl]-benzenesulfonamide;

4-[5-(4-chloro-phenyl)-3-cyclopropanecarbonyl-2-methyl-pyrrol-1yl]-benzenesulfonamide;

5-(4-chloro-phenyl)-1-(3-methanesulfonyl-phenyl)-2-methyl-1H-pyrrole-3-carboxylic acid;

5-(4-chloro-phenyl)-1-(3-methanesulfonyl-phenyl)-2-methyl-1H-pyrrole-3-carboxylic acid methoxy-methyl amide;

1-[5-(4-chloro-phenyl)-1-(3-methanesulfonyl-phenyl)-2-methyl-1H-pyrrol-3-yl]propan-1-one;

5-(4-chloro-phenyl)-1-(4-methanesulfonyl-phenyl)-2-methyl-1H-pyrrole-3-carboxaldehyde;

4-[5-(4-chloro-phenyl)-3-(4-hydroxymethyl-phenyl)-2-methyl-pyrrol-1yl]-benzenesulfonamide;

4-[3-benzofuran-2-yl-5-(4-chloro-phenyl)-2-methyl-pyrrol-1-yl]-benzenesulfonamide;

5-(4-chloro-phenyl)-2-methyl-1-(4-sulfamoyl-phenyl)-1H-pyrrole-3-carboxylic acid isopropylamide;

5-(4-chloro-phenyl)-2-methyl-1-(4-sulfamoyl-phenyl)-1H-pyrrole-3-carboxylic acid butylamide;

5-(4-chloro-phenyl)-2-methyl-1-(4-sulfamoyl-phenyl)-1H-pyrrole-3-carboxylic acid (2-methoxy-ethyl)-amide;

5-(4-chloro-phenyl)-2-methyl-1-(4-sulfamoyl-phenyl)-1H-pyrrole-3-carboxylic acid-(3-prop oxy-propyl)-amide;

5-(4-chloro-phenyl)-2-methyl-1-(4-sulfamoyl-phenyl)-1H-pyrrole-3-carboxylic acid-(R)-(tetrahydro-furan-2-ylmethyl)-amide;

5-(4-chloro-phenyl)-2-methyl-1-(4-sulfamoyl-phenyl)-1H-pyrrole-3-carboxylic acid (tetrahydro-furan-3-ylmethyl)-amide;

5-(4-chloro-phenyl)-2-methyl-1-(4-sulfamoyl-phenyl)-1H-pyrrole-3-carboxylic acid cyclobutylamide;

5-(4-chloro-phenyl)-2-methyl-1-(4-sulfamoyl-phenyl)-1H-pyrrole-3-carboxylic acid dimethylamide;

5-(4-chloro-phenyl)-2-methyl-1-(4-sulfamoyl-phenyl)-1H-pyrrole-3-carboxylic acid ethyl-methyl-amide;

5-(4-chloro-phenyl)-2-methyl-1-(4-sulfamoyl-phenyl)-1H-pyrrole-3-carboxylic acid isopropyl-methyl-amide;

4-[5-(4-chloro-phenyl)-2-methyl-3-(pyrrolidine-1-carbonyl)-pyrrol-1yl]-benzenesulfonamide;

4-[5-(4-chloro-phenyl)-2-methyl-3-(piperidine-1-carbonyl)-pyrrol-1yl]-benzenesulfonamide;

5-(4-chloro-phenyl)-2-methyl-1-(4-sulfamoyl-phenyl)-1H-pyrrole-3-carboxylic acid-(2-methoxy-ethyl)-methyl-amide;

5-(4-chloro-phenyl)-2-methyl-1-(4-sulfamoyl-phenyl)-1H-pyrrole-3-carboxylic acid-bis-(2-methoxy-ethyl)-amide;

4-[5-(4-chloro-phenyl)-2-methyl-3-(morpholine-4-carbonyl)-pyrrol-1yl]-benzenesulfonamide;

5-(4-chloro-phenyl)-2-methyl-1-(4-sulfamoyl-phenyl)-1H-pyrrole-3-carboxylic acid benzylamide;

5-(4-chloro-phenyl)-2-methyl-1-(4-sulfamoyl-phenyl)-1H-pyrrole-3-carboxylic acid (pyridin-3-ylmethyl)-amide;

5-(4-chloro-phenyl)-2-methyl-1-(4-sulfamoyl-phenyl)-1H-pyrrole-3-carboxylic acid (2-dimethylamino-ethyl)-amide;

5-(4-chloro-phenyl)-2-methyl-1-(4-sulfamoyl-phenyl)-1H-pyrrole-3-carboxylic acid-(3-dimethylamino-propyl)-amide;

5-(4-chloro-phenyl)-2-methyl-1-(4-sulfamoyl-phenyl)-1H-pyrrole-3-carboxylic acid-(2-hydroxy-ethyl)-propyl-amide;

5-(4-chloro-phenyl)-2-methyl-1-(4-sulfamoyl-phenyl)-1H-pyrrole-3-carboxylic acid-(3-hydroxy-propyl)-amide;

N-acetyl-4-[5-(4-chloro-phenyl)-2-methyl-3-propionyl-pyrrol-1-yl]-benzenesulfonamide;

N-acetyl-4-[5-(4-chloro-phenyl)-2-methyl-3-propionyl-pyrrol-1-yl]-benzenesulfonamide-N-sodium salt;

4-[5-(4-chloro-phenyl)-2-methyl-3-propionyl-pyrrol-1yl]-N-propionyl-benzenesulfonamide; and

4-[5-(4-chloro-phenyl)-2-methyl-3-propionyl-pyrrol-1yl]-N-propionyl-benzenesulfonamide-N-sodium salt.