Compositions and methods of making a photoactive agent
View Patent ↗A composition of matter of an anhydride of formula 1 below and an improved two stage reaction process for production of mono-L-aspartyl chlorin e 6 , utilizing the anhydride:
1. A composition, comprising a compound of Formula I:
or a pharmaceutically acceptable salt or ester thereof and at least one other chlorin species.
2. The composition of claim 1 wherein a total content of the Formula I compound, or a salt or ester thereof, is greater than about 85 wt % of the composition or 85 mol % based on the total amount of chlorin species present.
3. The composition of claim 1 wherein a total content of the Formula I compound, or a salt or ester thereof, is greater than about 90 wt % of the composition or 90 mol % based on the total amount of chlorin species present within the composition.
4. The composition of claim 1 wherein a total content of the Formula I compound, or a salt or ester thereof, is greater than about 95 wt % of the composition or 95 mol % based on the total amount of chlorin species present within the composition.