4-arylamin-or-4-heteroarylamino-quinazolines and analogs as activators of caspases and inducers of apoptosis and the use thereof

1. A compound according to Formula I:

or a pharmaceutically acceptable salt thereof, wherein:

R 1 is C 1-6 alkyl;

R 2 is —OR 14 , —SR 14 , or NR 14 R 15 wherein R 14 is arylalkyl or heteroarylalkyl and R 15 is H, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, or C 1-6 haloalkyl, and any of the groups are optionally substituted by halo, hydroxyl, carboxyl, amino, nitro, cyano, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, C 1-6 alkylthio, C 1-6 haloalkyl, C 1-6 acyl, C 1-6 acylamino, or C 1-6 acyloxy;

R 5 is H, F, or C 1-3 alkyl;

R 3 , R 4 , and R 6 -R 11 , are independently selected from:

(a) H, halo, N 3 , nitro, hydroxy, thiol, and CN,

(b) C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, C 1-10 alkoxy, C 1-10 alkylthiol, C 2-10 alkenyloxy, C 2-10 alkynyloxy, C 1-10 haloalkyl, C 1-10 hydroxyalkyl, C 1-6 alkyl-O—C 1-6 alkyl-, each of which being optionally substituted with 1-3 substituents wherein each substituent is independently halo, N 3 , nitro, hydroxy, thiol, CN, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy, carbocycle, heterocycle, aryl, heteroaryl, —N(R 50 )(R 51 ), —N(R 50 )C(═O)R 40 , —N(R 50 )C(═O)N(R 50 )(R 51 ), —C(═O)N(R 50 )(R 51 ), —OC(═O)N(R 50 )(R 51 ), R 40 C(═O)—, R 40 C(═O)O—, R 40 C(=G 1 )-, R 40 C(=G 1 )G 2 -, R 40 C(=G 1 )G 2 (R 50 )—, —C(=G 1 )G 2 R 41 or -G 3 C(=G 1 )G 2 R 41 ,

(c) carbocycle, heterocycle, aryl, and heteroaryl, each of which being optionally substituted with 1-3 substituents wherein each substituent is independently halo, N 3 , nitro, hydroxy, thiol, CN, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy, —N(R 52 )(R 53 ), —N(R 52 )C(═O)R 42 , —N(R 52 )C(═O)N(R 52 )(R 53 ), —C(═O)N(R 52 )(R 53 ), —OC(═O)N(R 52 )(R 53 ), R 42 C(═O)—, R 42 C(═O)O—, R 42 C(=G 1 )-, R 42 C(=G 1 )G 2 -, R 42 C(=G 1 )G 2 (R 52 )—, —C(=G 1 )G 2 R 43 , or -G 4 C(=G 1 )G 2 R 43 ,

(d) —N(R 50 )(R 51 ), —N(R 50 )C(═O)R 40 , —N(R 50 )C(═O)N(R 50 )(R 51 ), —C(═O)N(R 50 )(R 51 ), —OC(═O)N(R 50 )(R 51 ), R 40 C(═O)—, R 40 C(═O)O—, R 40 C(=G 1 )-, R 40 C(=G 1 )G 2 -, R 40 C(=G 1 )G 2 (R 50 )—, —C(=G 1 )G 2 R 41 or -G 3 C(=G 1 )G 2 R 41 , G 1 is S or N; G 2 and G 3 are independently S or N(R 50 ); G 4 is N(R 52 );

R 40 is selected from: H, —OH, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, C 2-6 alkenyloxy, C 2-6 alkynyloxy and C 1-6 alkylthiol, wherein R 40 is optionally substituted with from one to three substituents independently selected from halo, N 3 , nitro, hydroxy, thiol, CN, C 1-6 alkyl, carbocycle, heterocycle, aryl and heteroaryl;

R 41 is H, C 1-6 alkyl, C 2-6 alkenyl or C 2-6 alkynyl, wherein R 41 is optionally substituted with from one to three substituents independently selected from halo, N 3 , nitro, hydroxy, thiol, CN, C 1-6 alkyl, carbocycle, heterocycle, aryl and heteroaryl;

R 42 is selected from: H, —OH, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, C 2-6 alkenyloxy, C 2-6 alkynyloxy, and C 1-6 alkylthiol, wherein R 42 is optionally substituted with from one to three substituents independently selected from halo, N 3 , nitro, hydroxy, thiol, CN and C 1-6 alkyl;

R 43 is H, C 1-6 alkyl, C 2-6 alkenyl or C 2-6 alkynyl, wherein R 43 is optionally substituted with from one to three substituents independently selected from halo, N 3 , nitro, hydroxy, thiol, CN and C 1-6 alkyl;

R 50 and R 51 are independently H, OH(R 50 and R 51 are not both OH), C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, C 1-10 alkoxy, C 1-10 alkylthiol, C 2-10 alkenyloxy, C 2-10 alkynyloxy, C 1-10 haloalkyl, C 2-6 hydroxyalkyl, C 1-6 alkyl-O—C 1-6 alkyl-, carbocycle, heterocycle, aryl, heteroaryl, or R 50 and R 51 together with the nitrogen atom to which they are both linked form a 3, 4, 5 or 6-membered heterocycle, wherein R 50 and R 51 each is optionally substituted with 1-3 substituents wherein each substituent is independently halo, N 3 , nitro, hydroxy, thiol, CN, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy, —C(═O)N(R 54 )(R 55 ), R 44 C(═O)— or —N(R 54 )(R 55 ), wherein R 54 and R 55 are independently H, OH or C 1-4 alkyl, and wherein R 44 is H or C 1-4 alkyl;

R 52 and R 53 are independently H, OH(R 52 and R 53 are not both OH), C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, C 1-10 alkoxy, C 1-10 alkylthiol, C 2-10 alkenyloxy, C 2-10 alkynyloxy, C 1-10 haloalkyl, C 2-6 hydroxyalkyl, C 1-6 alkyl-O—C 1-6 alkyl-, or R 52 and R 53 together with the nitrogen atom to which they are both linked form a 3, 4, 5 or 6-membered heterocycle, wherein R 52 and R 53 each is optionally substituted with 1-3 substituents wherein each substituent is independently halo, N 3 , nitro, hydroxy, thiol, CN, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy, —C(═O)N(R 54 )(R 55 ), R 44 C(═O)— or —N(R 54 )(R 55 ), wherein R 54 and R 55 are independently H, OH or C 1-4 alkyl, and wherein R 44 is H or C 1-4 alkyl;

B and D are N and R 12 and R 13 are not present, Q, T, U, and V are C, and W, X, Y and Z are independently C or N, provided that W, X, Y or Z is N then there is no substituent at the N;

wherein any heterocycle or heteroaryl moiety is a 5 or 6-membered ring comprising from one to four heteroatoms independently selected from O, N, and S; and

with the proviso that the compound is not N 4 -methyl-N 2 -(2-methyl-benzyl)-N 4 -phenyl-quinazoline-2,4-diamine.

2. The compound of claim 1 wherein the compound has a structure according to Formula II:

or a pharmaceutically acceptable salt thereof, wherein:

R 1 is C 1-2 alkyl;

R 2 is —OR 14 , —SR 14 , or NR 14 R 15 wherein R 14 is arylalkyl or heteroarylalkyl and R 15 is H, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, or C 1-6 haloalkyl, and any of the groups are optionally substituted by halo, hydroxyl, carboxyl, amino, nitro, cyano, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, C 1-6 alkylthio, C 1-6 haloalkyl, C 1-6 acyl, C 1-6 acylamino, or C 1-6 acyloxy;

R 5 is H, F, or C 1-3 alkyl;

R 3 , R 4 , and R 6 -R 11 are independently selected from:

(a) H, halo, N 3 , nitro, hydroxy, thiol, and CN,

(b) C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, C 1-10 alkoxy, C 1-10 alkylthiol, C 2-10 alkenyloxy, C 2-10 alkynyloxy, C 1-10 haloalkyl, C 1-10 hydroxyalkyl, C 1-6 alkyl-O—C 1-6 alkyl-, each of which being optionally substituted with 1-3 substituents wherein each substituent is independently halo, N 3 , nitro, hydroxy, thiol, CN, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy, carbocycle, heterocycle, aryl, heteroaryl, —N(R 50 )(R 51 ), —N(R 50 )C(═O)R 40 , —N(R 50 )C(═O)N(R 50 )(R 51 ), —C(═O)N(R 50 )(R 51 ), —OC(═O)N(R 50 )(R 51 ), R 40 C(═O)—, R 40 C(═O)O—, R 40 C(=G 1 )-, R 40 C(=G 1 )G 2 -, R 40 C(=G 1 )G 2 (R 50 )—, —C(=G 1 )G 2 R 41 or -G 3 C(=G 1 )G 2 R 41 ,

(c) carbocycle, heterocycle, aryl, and heteroaryl, each of which being optionally substituted with 1-3 substituents wherein each substituent is independently halo, N 3 , nitro, hydroxy, thiol, CN, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy, —N(R 52 )(R 53 ), —N(R 52 )C(═O)R 42 , —N(R 52 )C(═O)N(R 52 )(R 53 ), —C(═O)N(R 52 )(R 53 ), —OC(═O)N(R 52 )(R 53 ), R 42 C(═O)—, R 42 C(═O)O—, R 42 C(=G 1 )-, R 42 C(=G 1 )G 2 -, R 42 C(=G 1 )G 2 (R 52 )—, —C(=G 1 )G 2 R 43 , or -G 4 C(=G 1 )G 2 R 43 ,

(d) —N(R 50 )(R 51 ), —N(R 50 )C(═O)R 40 , —N(R 50 )C(═O)N(R 50 )(R 51 ), —C(═O)N(R 50 )(R 51 ), —OC(═O)N(R 50 )(R 51 ), R 40 C(═O)—, R 40 C(═O)O—, R 40 C(=G 1 )-, R 40 C(=G 1 )G 2 -, R 40 C(=G 1 )G 2 (R 50 )—, —C(=G 1 )G 2 R 41 or -G 3 C(=G 1 )G 2 R 41 , G 1 is S or N; G 2 and G 3 are independently S or N(R 50 ); G 4 is N(R 52 );

R 40 is selected from: H, —OH, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, C 2-6 alkenyloxy, C 2-6 alkynyloxy and C 1-6 alkylthiol, wherein R 40 is optionally substituted with from one to three substituents independently selected from halo, N 3 , nitro, hydroxy, thiol, CN, C 1-6 alkyl, carbocycle, heterocycle, aryl and heteroaryl;

R 41 is H, C 1-6 alkyl, C 2-6 alkenyl or C 2-6 alkynyl, wherein R 41 is optionally substituted with from one to three substituents independently selected from halo, N 3 , nitro, hydroxy, thiol, CN, C 1-6 alkyl, carbocycle, heterocycle, aryl and heteroaryl;

R 42 is selected from: H, —OH, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, C 2-6 alkenyloxy, C 2-6 alkynyloxy, and C 1-6 alkylthiol, wherein R 42 is optionally substituted with from one to three substituents independently selected from halo, N 3 , nitro, hydroxy, thiol, CN and C 1-6 alkyl;

R 43 is H, C 1-6 alkyl, C 2-6 alkenyl or C 2-6 alkynyl, wherein R 43 is optionally substituted with from one to three substituents independently selected from halo, N 3 , nitro, hydroxy, thiol, CN and C 1-6 alkyl;

R 50 and R 51 are independently H, OH(R 50 and R 51 are not both OH), C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, C 1-10 alkoxy, C 1-10 alkylthiol, C 2-10 alkenyloxy, C 2-10 alkynyloxy, C 1-10 haloalkyl, C 2-6 hydroxyalkyl, C 1-6 alkyl-O—C 1-6 alkyl-, carbocycle, heterocycle, aryl, heteroaryl, or R 50 and R 51 together with the nitrogen atom to which they are both linked form a 3, 4, 5 or 6-membered heterocycle, wherein R 50 and R 51 each is optionally substituted with 1-3 substituents wherein each substituent is independently halo, N 3 , nitro, hydroxy, thiol, CN, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy, —C(═O)N(R 54 )(R 55 ), R 44 C(═O)— or —N(R 54 )(R 55 ), wherein R 54 and R 55 are independently H, OH or C 1-4 alkyl, and wherein R 44 is H or C 1-4 alkyl;

R 52 and R 53 are independently H, OH(R 52 and R 53 are not both OH), C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, C 1-10 alkoxy, C 1-10 alkylthiol, C 2-10 alkenyloxy, C 2-10 alkynyloxy, C 1-10 haloalkyl, C 2-6 hydroxyalkyl, C 1-6 alkyl-O—C 1-6 alkyl-, or R 52 and R 53 together with the nitrogen atom to which they are both linked form a 3, 4, 5 or 6-membered heterocycle, wherein R 52 and R 53 each is optionally substituted with 1-3 substituents wherein each substituent is independently halo, N 3 , nitro, hydroxy, thiol, CN, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy, —C(═O)N(R 54 )(R 55 ), R 44 C(═O)— or —N(R 54 )(R 55 ), wherein R 54 and R 55 are independently H, OH or C 1-4 alkyl, and wherein R 44 is H or C 1-4 alkyl;

wherein any heterocycle or heteroaryl moiety is a 5 or 6-membered ring comprising from one to four heteroatoms independently selected from O, N, and S.

3. The compound of claim 2 , with the proviso that when R 2 is methylbenzylamino then R 9 is not H.

4. The compound of claim 3 , wherein:

R 1 is C 1-2 alkyl;

R 2 is —OR 14 , —SR 14 , or NR 14 R 14 wherein R 14 is arylalkyl or heteroarylalkyl and R 15 is H, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, or C 1-6 haloalkyl, and any of the groups are optionally substituted by halo, hydroxyl, carboxyl, amino, nitro, cyano, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, C 1-6 alkylthio, C 1-6 haloalkyl, C 1-6 acyl, C 1-6 acylamino, or C 1-6 acyloxy;

R 3 , R 4 , R 6 -R 8 , R 10 , R 11 , and R 12 and R 13 if present, are independently R 16 , OR 16 , SR 16 or NR 16 R 17 , wherein R 16 and R 17 are independently H, halo, hydroxyl, carboxyl, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, or C 1-6 haloalkyl; wherein any of the groups are optionally substituted with one or more halo, C 1-6 haloalkyl, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 hydroxyalkyl, nitro, amino, ureido, cyano, C 1-6 acylamino, hydroxy, thiol, C 1-6 acyloxy, azido, C 1 -C 6 alkoxy, carboxy or C 1-2 alkylenedioxy;

R 5 is H, F, or C 1-3 alkyl; and

R 9 is H; OH; halo; N 3 ; C 1-6 alkyl; C 1-6 haloalkyl —OR 9a , wherein R 9a is C 1-6 alkyl or C 1-6 haloalkyl; —NH(R a ) or —N(R a )(R b ) where R a and R b are independently C 1-6 alkyl, C 1-6 acyl, C 1-6 acyloxy, amino, —(C═O)N(R c )(R d ) wherein R c and R d are independently H or C 1-6 alkyl; or —COOR 9b , wherein R 9b is C 1-6 alkyl; optionally R 9 and one of R 8 and R 10 together form a 3, 4, 5, or 6-membered heterocycle; and any of the groups are optionally substituted with one or more halo, C 1-6 haloalkyl, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 hydroxyalkyl, nitro, amino, ureido, cyano, C 1-6 acylamino, hydroxy, thiol, C 1-6 acyloxy, azido, C 1 -C 6 alkoxy, carboxy or C 1-2 alkylenedioxy;

wherein, unless indicated otherwise, any heterocycle or heteroaryl moiety is a 5 or 6-membered ring comprising from one to four heteroatoms independently selected from O, N, and S.

5. The compound of claim 4 , wherein:

R 2 is NR 14 R 15 , wherein R 14 is arylalkyl or heteroarylalkyl and R 15 is H, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, or C 1-6 haloalkyl; and each group is optionally substituted by halo, hydroxyl, carboxyl, amino, nitro, cyano, C 1-3 alkyl, C 2-3 alkenyl, C 2-3 alkynyl, C 1-3 alkoxy, C 1-3 alkylthio, C 1-3 haloalkyl, C 1-3 acyl, C 1-3 acylamino, or C 1-6 acyloxy;

wherein any heteroaryl moiety is a 5 or 6-membered ring comprising from one to four heteroatoms independently selected from O, N, and S.

6. The compound of claim 4 , wherein:

R 9 is H; OH; Cl; N 3 ; C 1-3 alkyl; C 1-3 haloalkyl; —OR 9a , wherein R 9a is C 1-4 alkyl or C 1-3 haloalkyl; —NH(R a ) or —N(R a )(R b ) where R a and R b are independently C 1-3 alkyl, C 1-3 acyl, C 1-3 acyloxy, —(C═O)N(R e )(R f ) wherein R e and R f are independently H, or C 1-3 alkyl; or —COOR 9b , wherein R 9b is C 1-3 alkyl; and optionally R 9 and one of R 8 and R 10 together form a 3, 4, 5, or 6-membered heterocycle;

wherein any heterocycle moiety comprises from one to four heteroatoms independently selected from O, N, and S.

7. The compound of claim 5 , wherein:

R 9 is selected from the group:

—OR 19 , wherein R 19 is methyl, ethyl, fluoromethyl, or fluoroethyl;

—NHCH 3 ;

—N(CH 3 ) 2 ;

—N 3 ;

—COOR 20 ; and

—NC(O)N(R 21 )(R 22 ) or —NC(O)R 20 wherein R 20 is methyl or ethyl; and R 21 and

R 22 are independently H, methyl or ethyl.

8. The compound of claim 7 , wherein:

R 3 is H; halo; C 1-3 alkyl; or C 1-3 alkoxy;

R 4 and R 6 are independently H; halo; NO 2 , N 3 ; C 1-6 alkyl; C 1-3 alkoxy; or —N(R 2b )(R 2c ) wherein R 2b and R 2c are independently H, OH, C 1-6 alkyl, C 1-6 hydroxyalkyl, C 1-6 acyl, C 1-6 acyloxy, C 1-6 acylamido, or C 1-6 alkyl that is optionally substituted with —N(R 2d )(R 2e ) wherein R 2d and R 2e are independently H, OH, C 1-3 alkyl or C 2-3 hydroxyalkyl, wherein

R 2b and R 2c together may form a 3, 4, 5 or 6-membered heterocycle, and wherein R 2b and

R 2c are not both OH, R 2d and R 2e are not both OH;

R 5 is H or F;

R 7 and R 11 are independently H; halo; CH 3 ; or OCH 3 ; and

R 8 and R 10 are independently H; halo; OH; N 3 ; C 1-3 alkyl; C 1-3 alkoxy; C 1-3 haloalkyl; —OR 9a , —SR 9a , where R 9a is C 1-4 alkyl or C 1-3 haloalkyl; —NH(R a ) or —N(R a )(R b ) where R a and R b are independently C 1-3 alkyl; or —COOR 9b , wherein R 9b is C 1-3 alkyl;

wherein any heterocycle moiety comprises from one to four heteroatoms independently selected from O, N, and S.

9. A compound according to claim 1 , wherein the compound is selected from:

(2-Benzylamino-quinazolin-4-yl)-(4-methoxyphenyl)-methylamine;

[2-(4-Methoxy-benzylamino)-quinazolin-4-yl)]-(4-methoxyphenyl)-methylamine;

or a pharmaceutically acceptable salt thereof.

10. A compound according to Formula I:

or a pharmaceutically acceptable salt thereof, wherein:

R 1 is C 1-2 alkyl;

R 2 is —N(R 50 )C(═O)R 40 , —N(R 50 )C(═O)N(R 50 )(R 51 ), C(═O)N(R 50 )(R 51 ), or —OC(═O)N(R 50 )(R 51 ); wherein

R 40 is selected from: H, —OH, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 1-4 alkoxy, C 2-4 alkenyloxy, C 2-4 alkynyloxy and C 1-4 alkylthiol, wherein R 40 is optionally substituted with from one to three substituents independently selected from halo, N 3 , nitro, hydroxy, thiol, CN, and C 1-4 alkyl; and

R 50 and R 51 are independently H, OH(R 50 and R 51 are not both OH), C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 1-4 alkoxy, C 1-4 alkylthiol, C 2-4 alkenyloxy, C 2-4 alkynyloxy, C 1-4 haloalkyl, C 2-4 hydroxyalkyl, C 1-4 alkyl-O—C 1-4 alkyl-, or R 50 and R 51 together with the nitrogen atom to which they are both linked form a 3, 4, 5 or 6-membered heterocycle;

R 3 , R 4 , R 6 -R 8 , R 10 -R 13 are independently R 16 , OR 16 , SR 16 , NR 16 R 17 , or NO 2 , wherein R 16 and R 17 are independently H, halo, hydroxyl, carboxyl, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, or C 1-6 haloalkyl; wherein any of the groups are optionally substituted with one or more halo, C 1-6 haloalkyl, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 hydroxyalkyl, nitro, amino, ureido, cyano, C 1-6 acylamino, hydroxy, thiol, C 1-6 acyloxy, azido, C 1 -C 6 alkoxy, carboxy or C 1-2 alkylenedioxy;

R 5 is H, F, or C 1-3 alkyl;

R 9 is H; OH; halo; N 3 ; C 1-6 alkyl; C 1-6 haloalkyl —OR 9a , wherein R 9a is C 1-6 alkyl or C 1-6 haloalkyl; —NH(R g ) or —N(R g )(R h ) where R g and R h are independently C 1-6 alkyl, C 1-6 acyl, C 1-6 acyloxy, amino, —(C═O)N(R j )(R k ) wherein R j and R k are independently H or C 1-6 alkyl; or —COOR 9b , wherein R 9b is C 1-6 alkyl; optionally R 9 and one of R 8 and R 10 together form a 3, 4, 5, or 6-membered heterocycle; and any of the groups are optionally substituted with one or more halo, C 1-6 haloalkyl, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 hydroxyalkyl, nitro, amino, ureido, cyano, C 1-6 acylamino, hydroxy, thiol, C 1-6 acyloxy, azido, C 1 -C 6 alkoxy, carboxy or C 1-2 alkylenedioxy; and

B and D are N and R 12 and R 13 are not present, Q, T, U, and V are C, and W, X, Y and Z are independently C or N, provided that when W, X, Y or Z is N then there is no substituent at the N;

wherein any heterocycle moiety comprises from one to four heteroatoms independently selected from O, N, and S.

11. A compound according to Formula II:

or a pharmaceutically acceptable salt thereof, wherein:

R 1 is C 1-2 alkyl;

R 2 is H; halo; NHNH 2 , N 3 ; C 1-6 alkyl optionally substituted with OH or halo; —OR 2a or —SR 2a wherein R ea is C 1-6 alkyl optionally substituted with OH or halo; —CO 2 C 1-3 alkyl;

or —N(R a )(R b ) wherein R a and R b are independently H, OH(R a and R b are not both OH), C 1-3 alkyl, C 1-6 hydroxyalkyl, C 1-3 acyl, C 1-3 acyloxy, (C═O)N(R e )(R f ) or C 1-6 alkyl that is optionally substituted with —N(R e )(R f ) wherein R e and R f are independently H, OH(R e and R f are not both OH), C 1-3 alkyl, or C 2-3 hydroxyalkyl, and wherein optionally R a and R b together with the nitrogen they both are linked to may form a 3, 4, 5 or 6-membered heterocycle;

R 3 , R 4 , R 6 -R 8 , R 10 and R 11 are independently R 16 , OR 16 , SR 16 , NR 16 R 17 , or NO 2 , wherein R 16 and R 17 are independently H, halo, hydroxyl, carboxyl, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, or C 1-6 haloalkyl; wherein any of the groups are optionally substituted with one or more halo, C 1-6 haloalkyl, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 hydroxyalkyl, nitro, amino, ureido, cyano, C 1-6 acylamino, hydroxy, thiol, C 1-6 acyloxy, azido, C 1 -C 6 alkoxy, carboxy or C 1-2 alkylenedioxy;

R 5 is H, F, or C 1-3 alkyl; and

R 9 is —N(R 50 )C(═O)R 40 , —N(R 50 )C(═O)N(R 50 )(R 51 ), C(═O)N(R 50 )(R 51 ), or —OC(═O)N(R 50 )(R 51 ); wherein

R 40 is selected from: H, —OH, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 1-4 alkoxy, C 2-4 alkenyloxy, C 2-4 alkynyloxy and C 1-4 alkylthiol, wherein R 40 is optionally substituted with from one to three substituents independently selected from halo, N 3 , nitro, hydroxy, thiol, CN, and C 1-4 alkyl; and R 50 and R 51 are independently H, OH(R 50 and R 51 are not both OH), C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 1-4 alkoxy, C 1-4 alkylthiol, C 2-4 alkenyloxy, C 2-4 alkynyloxy, C 1-4 haloalkyl, C 2-4 hydroxyalkyl, C 1-4 alkyl-O—C 1-4 alkyl-, or R 50 and R 51 together with the nitrogen atom to which they are both linked form a 3, 4, 5 or 6-membered heterocycle;

wherein any heterocycle moiety comprises from one to four heteroatoms independently selected from O, N, and S.

12. The compound of claim 11 , wherein

R 3 is H; halo; C 1-3 alkyl; or C 1-3 alkoxy;

R 4 and R 6 are independently H; halo; NO 2 , N 3 ; C 1-6 alkyl; C 1-3 alkoxy; or —N(R 2b )(R 2c ) wherein R 2b and R 2c are independently H, OH, C 1-6 alkyl, C 1-6 hydroxyalkyl, C 1-6 acyl, C 1-6 acyloxy, C 1-6 acylamido, or C 1-6 alkyl that is optionally substituted with —N(R 2d )(R 2e ) wherein R 2d and R 2e are independently H, OH, C 1-3 alkyl or C 2-3 hydroxyalkyl, wherein R 2b and R 2e together may form a 3, 4, 5 or 6-membered heterocycle, and wherein R 2b and R 2c are not both OH, R 2d and R 2e are not both OH;

R 5 is H or F;

R 7 and R 11 are independently H; halo; CH 3 ; or OCH 3 ; and

R 8 and R 10 are independently H; halo; OH; N 3 ; C 1-3 alkyl; C 1-3 alkoxy; C 1-3 haloalkyl; —OR 9a , —SR 9a , where R 9a is C 1-4 alkyl or C 1-3 haloalkyl; —NH(R a ) or —N(R a )(R b ) where R a and R b are independently C 1-3 alkyl; or —COOR 9b , wherein R 9b is C 1-3 alkyl;

wherein any heterocycle moiety comprises from one to four heteroatoms independently selected from O, N, and S.

13. A compound according to claim 10 wherein the compound is selected from:

(2-Methylamino-quinazolin-4-yl)-(4-dimethylaminophenyl)-methylamine;

[2-(N-Methyl-acetamido)-quinazolin-4-yl]-(4-dimethylaminophenyl)-methylamine;

(4-Methoxy-phenyl)-(2-N-methylacetamido-quinazolin-4-yl)-methylamine;

(4-Methoxy-phenyl)-(2-N-methyl-methoxycarbonylamino-quinazolin-4-yl)-methylamine;

(2-Hydrazinyl-quinazolin-4-yl)-(4-methoxy-phenyl)-methylamine;

(2-Acetamido-quinazolin-4-yl)-(4-methoxy-phenyl)-methylamine; or a

pharmaceutically acceptable salt thereof.

14. A compound according to claim 10 wherein the compound is selected from:

(2-Methyl-6-nitroquinazolin-4-yl)-(4-dimethylaminophenyl)-methylamine;

(2-Chloro-6-nitroquinazolin-4-yl)-(4-methoxyphenyl)-methylamine;

(6-Amino-2-methyl-quinazolin-4-yl)-(4-dimethylaminophenyl)-methylamine;

(2-Dimethylamino-6-nitroquinazolin-4-yl)-(4-methoxyphenyl)-methylamine;

(2-Methylamino-6-nitroquinazolin-4-yl)-(4-methoxyphenyl)-methylamine;

(6-Amino-2-dimethylamino-quinazolin-4-yl)-(4-methoxyphenyl)-methylamine;

(6-Amino-2-methylamino-quinazolin-4-yl)-(4-methoxyphenyl)-methylamine;

(6-Dimethylamino-2-methyl-quinazolin-4-yl)-(4-methoxy-phenyl)-methylamine;

(6-Acetamido-2-methyl-quinazolin-4-yl)-(4-methoxy-phenyl)-methylamine;

(6-methoxycarbonylamino-2-methyl-quinazolin-4-yl)-(4-methoxy-phenyl)-methylamine;

(3,4-Dimethoxy-phenyl)-(2-methyl-6-nitro-quinazolin-4-yl)-methylamine;

(6-N-methyl-acetamido-2-methyl-quinazolin-4-yl)-(4-methoxy-phenyl) methylamine; or a pharmaceutically acceptable salt thereof.

15. A compound according to claim 10 wherein the compound is selected from:

(4-Acetamido-phenyl)-(2-methyl-quinazolin-4-yl)-methylamine;

(2-Methyl-quinazolin-4-yl)-(4-methoxycarbonylamino-phenyl)-methylamine;

(2-Methyl-quinazolin-4-yl)-(4-ureido-phenyl)-methylamine;

(2-Methyl-quinazolin-4-yl)-(N-methyl-4-acetamido-phenyl)-methylamine;

(2-Methyl-quinazolin-4-yl)-(4-methylamino-phenyl)-methylamine;

(2-Methyl-quinazolin-4-yl)-[4-(N-methyl-methoxycarbonylamino)-phenyl]-methylamine;

(2-Chloro-quinazolin-4-yl)-(4-dimethylaminophenyl)-methylamine;

(4-Methylthio-phenyl)-(2-methyl-quinazolin-4-yl)-methylamine;

(3,4-Dimethoxy-phenyl)-(2-methyl-quinazolin-4-yl)-methylamine;

(2-Dimethylamino-pyridine-5-yl)-(2-methyl-quinazolin-4-yl)-methylamine;

N-{4-[Methyl(2-methylquinazolin-4-yl)amino]phenyl}formamide; or a pharmaceutically acceptable salt thereof.

16. A compound according to Formula I:

or a pharmaceutically acceptable salt thereof, wherein:

R 1 is methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, 3-pentyl, or hexyl;

R 2 -R 13 , are independently selected from:

(a) H, halo, N 3 , nitro, hydroxy, thiol, and CN,

(b) C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, C 1-10 alkoxy, C 1-10 alkylthiol, C 2-10 alkenyloxy, C 2-10 alkynyloxy, C 1-10 haloalkyl, C 1-10 hydroxyalkyl, C 1-6 alkyl-O—C 1-6 alkyl-, each of which being optionally substituted with 1-3 substituents wherein each substituent is independently halo, N 3 , nitro, hydroxy, thiol, CN, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy, carbocycle, heterocycle, aryl, heteroaryl, —N(R 50 )(R 51 ), —N(R 50 )C(═O)R 40 , —N(R 50 )C(═O)N(R 50 )(R 51 ), —C(═O)N(R 50 )(R 51 ), —OC(═O)N(R 50 )(R 51 ), R 40 C(═O)—, R 40 C(═O)O—, R 40 C(=G 1 )-, R 40 C(=G 1 )G 2 -, R 40 C(=G 1 )G 2 (R 50 )—, —C(=G 1 )G 2 R 41 or -G 3 C(=G 1 )G 2 R 41 ,

(c) carbocycle, heterocycle, aryl, and heteroaryl, each of which being optionally substituted with 1-3 substituents wherein each substituent is independently halo, N 3 , nitro, hydroxy, thiol, CN, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy, —N(R 52 )(R 53 ), —N(R 52 )C(═O)R 42 , —N(R 52 )C(═O)N(R 52 )(R 53 ), —C(═O)N(R 52 )(R 53 ), —OC(═O)N(R 52 )(R 53 ), R 42 C(═O)—, R 42 C(═O)O—, R 42 C(=G 1 )-, R 42 C(=G 1 )G 2 -, R 42 C(=G 1 )G 2 (R 52 )—, —C(=G 1 )G 2 R 43 , or -G 4 C(=G 1 )G 2 R 43 ,

(d) —N(R 50 )(R 51 ), —N(R 50 )C(═O)R 40 , —N(R 50 )C(═O)N(R 50 )(R 51 ), —C(═O)N(R 50 )(R 51 ), —OC(═O)N(R 50 )(R 51 ), R 40 C(═O)—, R 40 C(═O)O—, R 40 C(=G 1 )-, R 40 C(=G 1 )G 2 -, R 40 C(=G 1 )G 2 (R 50 )—, —C(=G 1 )G 2 R 41 or -G 3 C(=G 1 )G 2 R 41 ,

G 1 is S or N; G 2 and G 3 are independently S or N(R 50 ); G 4 is N(R 52 );

R 40 is selected from: H, —OH, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, C 2-6 alkenyloxy, C 2-6 alkynyloxy and C 1-6 alkylthiol, wherein R 40 is optionally substituted with from one to three substituents independently selected from halo, N 3 , nitro, hydroxy, thiol, CN, C 1-6 alkyl, carbocycle, heterocycle, aryl and heteroaryl;

R 41 is H, C 1-6 alkyl, C 2-6 alkenyl or C 2-6 alkynyl, wherein R 41 is optionally substituted with from one to three substituents independently selected from halo, N 3 , nitro, hydroxy, thiol, CN, C 1-6 alkyl, carbocycle, heterocycle, aryl and heteroaryl;

R 42 is selected from: H, —OH, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, C 2-6 alkenyloxy, C 2-6 alkynyloxy, and C 1-6 alkylthiol, wherein R 42 is optionally substituted with from one to three substituents independently selected from halo, N 3 , nitro, hydroxy, thiol, CN and C 1-6 alkyl;

R 43 is H, C 1-6 alkyl, C 2-6 alkenyl or C 2-6 alkynyl, wherein R 43 is optionally substituted with from one to three substituents independently selected from halo, N 3 , nitro, hydroxy, thiol, CN and C 1-6 alkyl;

R 50 and R 51 are independently H, OH(R 50 and R 51 are not both OH), C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, C 1-10 alkoxy, C 1-10 alkylthiol, C 2-10 alkenyloxy, C 2-10 alkynyloxy, C 1-10 haloalkyl, C 2-6 hydroxyalkyl, C 1-6 alkyl-O—C 1-6 alkyl-, carbocycle, heterocycle, aryl, heteroaryl, or R 50 and R 51 together with the nitrogen atom to which they are both linked form a 3, 4, 5 or 6-membered heterocycle, wherein R 50 and R 51 each is optionally substituted with 1-3 substituents wherein each substituent is independently halo, N 3 , nitro, hydroxy, thiol, CN, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy, —C(═O)N(R 54 )(R 55 ), R 44 C(═O)— or —N(R 54 )(R 55 ), wherein R 54 and R 55 are independently H, OH or C 1-4 alkyl, and wherein R 44 is H or C 1-4 alkyl;

R 52 and R 53 are independently H, OH(R 52 and R 53 are not both OH), C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, C 1-10 alkoxy, C 1-10 alkylthiol, C 2-10 alkenyloxy, C 2-10 alkynyloxy, C 1-10 haloalkyl, C 2-6 hydroxyalkyl, C 1-6 alkyl-O—C 1-6 alkyl-, or R 52 and R 53 together with the nitrogen atom to which they are both linked form a 3, 4, 5 or 6-membered heterocycle, wherein R 52 and R 53 each is optionally substituted with 1-3 substituents wherein each substituent is independently halo, N 3 , nitro, hydroxy, thiol, CN, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy, —C(═O)N(R 54 )(R 55 ), R 44 C(═O)— or —N(R 54 )(R 55 ), wherein R 54 and R 55 are independently H, OH or C 1-4 alkyl, and wherein R 44 is H or C 1-4 alkyl;

B and D are N and R 12 and R 13 are not present, Q, T, U, and V are C, and W, X, Y and Z are independently C or N, provided that W, X, Y or Z is N then there is no substituent at the N;

wherein any heterocycle or heteroaryl moiety, unless indicated otherwise, is a 5 or 6-membered ring comprising from one to four heteroatoms independently selected from O, N, and S; and

wherein at least one of R 2 -R 13 is R 40 C(=G 1 )-, R 40 C(=G 1 )G 2 -, R 40 C(=G 1 )G 2 (R 50 )—, —C(=G 1 )G 2 R 41 or -G 3 C(=G 1 )G 2 R 41 .

17. The compound of claim 16 wherein the compound has a structure according to Formula II:

or a pharmaceutically acceptable salt thereof, wherein:

R 1 is methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, 3-pentyl, or hexyl;

R 2 -R 11 , are independently selected from:

(a) H, halo, N 3 , nitro, hydroxy, thiol, and CN,

(b) C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, C 1-10 alkoxy, C 1-10 alkylthiol, C 2-10 alkenyloxy, C 2-10 alkynyloxy, C 1-10 haloalkyl, C 1-10 hydroxyalkyl, C 1-6 alkyl-O—C 1-6 alkyl-, each of which being optionally substituted with 1-3 substituents wherein each substituent is independently halo, N 3 , nitro, hydroxy, thiol, CN, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy, carbocycle, heterocycle, aryl, heteroaryl, —N(R 50 )(R 51 ), —N(R 50 )C(═O)R 40 , —N(R 50 )C(═O)N(R 50 )(R 51 ), —C(═O)N(R 50 )(R 51 ), —OC(═O)N(R 50 )(R 51 ), R 40 C(═O)—, R 40 C(═O)O—, R 40 C(=G 1 )-, R 40 C(=G 1 )G 2 -, R 40 C(=G 1 )G 2 (R 50 )—, —C(=G 1 )G 2 R 41 or -G 3 C(=G 1 )G 2 R 41 ,

(c) carbocycle, heterocycle, aryl, and heteroaryl, each of which being optionally substituted with 1-3 substituents wherein each substituent is independently halo, N 3 , nitro, hydroxy, thiol, CN, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy, —N(R 52 )(R 53 ), —N(R 52 )C(═O)R 42 , —N(R 52 )C(═O)N(R 52 )(R 53 ), —C(═O)N(R 52 )(R 53 ), —OC(═O)N(R 52 )(R 53 ), R 42 C(═O)—, R 42 C(═O)O—, R 42 C(=G 1 )-, R 42 C(=G 1 )G 2 -, R 42 C(=G 1 )G 2 (R 52 )—, —C(=G 1 )G 2 R 43 , or -G 4 C(=G 1 )G 2 R 43 ,

(d) —N(R 50 )(R 51 ), —N(R 50 )C(═O)R 40 , —N(R 50 )C(═O)N(R 50 )(R 51 ), —C(═O)N(R 50 )(R 51 ), —OC(═O)N(R 50 )(R 51 ), R 40 C(═O)—, R 40 C(═O)O—, R 40 C(=G 1 )-, R 40 C(=G 1 )G 2 -, R 40 C(=G 1 )G 2 (R 50 )—, —C(=G 1 )G 2 R 41 or -G 3 C(=G 1 )G 2 R 41 ,

G 1 is S or N; G 2 and G 3 are independently S or N(R 50 ); G 4 is N(R 52 );

R 40 is selected from: H, —OH, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, C 2-6 alkenyloxy, C 2-6 alkynyloxy and C 1-6 alkylthiol, wherein R 40 is optionally substituted with from one to three substituents independently selected from halo, N 3 , nitro, hydroxy, thiol, CN, C 1-6 alkyl, carbocycle, heterocycle, aryl and heteroaryl;

R 41 is H, C 1-6 alkyl, C 2-6 alkenyl or C 2-6 alkynyl, wherein R 41 is optionally substituted with from one to three substituents independently selected from halo, N 3 , nitro, hydroxy, thiol, CN, C 1-6 alkyl, carbocycle, heterocycle, aryl and heteroaryl;

R 42 is selected from: H, —OH, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, C 2-6 alkenyloxy, C 2-6 alkynyloxy, and C 1-6 alkylthiol, wherein R 42 is optionally substituted with from one to three substituents independently selected from halo, N 3 , nitro, hydroxy, thiol, CN and C 1-6 alkyl;

R 43 is H, C 1-6 alkyl, C 2-6 alkenyl or C 2-6 alkynyl, wherein R 43 is optionally substituted with from one to three substituents independently selected from halo, N 3 , nitro, hydroxy, thiol, CN and C 1-6 alkyl;

R 50 and R 51 are independently H, OH(R 50 and R 51 are not both OH), C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, C 1-10 alkoxy, C 1-10 alkylthiol, C 2-10 alkenyloxy, C 2-10 alkynyloxy, C 1-10 haloalkyl, C 2-6 hydroxyalkyl, C 1-6 alkyl-O—C 1-6 alkyl-, carbocycle, heterocycle, aryl, heteroaryl, or R 50 and R 51 together with the nitrogen atom to which they are both linked form a 3, 4, 5 or 6-membered heterocycle, wherein R 50 and R 51 each is optionally substituted with 1-3 substituents wherein each substituent is independently halo, N 3 , nitro, hydroxy, thiol, CN, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy, —C(═O)N(R 54 )(R 55 ), R 44 C(═O)— or —N(R 54 )(R 55 ), wherein R 54 and R 55 are independently H, OH or C 1-4 alkyl, and wherein R 44 is H or C 1-4 alkyl;

R 52 and R 53 are independently H, OH(R 52 and R 53 are not both OH), C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, C 1-10 alkoxy, C 1-10 alkylthiol, C 2-10 alkenyloxy, C 2-10 alkynyloxy, C 1-10 haloalkyl, C 2-6 hydroxyalkyl, C 1-6 alkyl-O—C 1-6 alkyl-, or R 52 and R 53 together with the nitrogen atom to which they are both linked form a 3, 4, 5 or 6-membered heterocycle, wherein R 52 and R 53 each is optionally substituted with 1-3 substituents wherein each substituent is independently halo, N 3 , nitro, hydroxy, thiol, CN, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy, —C(═O)N(R 54 )(R 55 ), R 44 C(═O)— or —N(R 54 )(R 55 ), wherein R 54 and R 55 are independently H, OH or C 1-4 alkyl, and wherein R 44 is H or C 1-4 alkyl;

wherein any heterocycle or heteroaryl moiety, unless indicated otherwise, is a 5 or 6-membered ring comprising from one to four heteroatoms independently selected from O, N, and S; and

wherein at least one of R 2 -R 11 is R 40 C(=G 1 )-, R 40 C(=G 1 )G 2 -, R 40 C(=G 1 )G 2 (R 50 )—, —C(=G 1 )G 2 R 41 or -G 3 C(=G 1 )G 2 R 41 .

18. The compound of claim 17 wherein:

R 2 is R 40 C(=G 1 )-, R 40 C(=G 1 )G 2 -, R 40 C(=G 1 )G 2 (R 50 )—, —C(=G 1 )G 2 R 41 or -G 3 C(=G 1 )G 2 R 41 ; wherein R 40 , R 41 , R 50 , G 1 , G 2 , and G 3 are as defined in claim 17 .

19. The compound of claim 17 wherein:

R 9 is R 40 C(=G 1 )-, R 40 C(=G 1 )G 2 -, R 40 C(=G 1 )G 2 (R 50 )—, —C(=G 1 )G 2 R 41 or -G 3 C(=G 1 )G 2 R 41 ; wherein R 40 , R 41 , R 50 , G 1 , G 2 , and G 3 are as defined in claim 17 .

20. The compound of claim 18 wherein:

R 9 is selected from the group:

—OR 19 , wherein R 19 is selected from the group of methyl, ethyl, fluoromethyl, and fluoroethyl;

—NHCH 3 ;

—N(CH 3 ) 2 ;

—N 3 ;

—COOR 20 ; and

—NC(O)N(R 21 )(R 22 ) or —NC(O)R 20 wherein R 20 is methyl or ethyl; and R 21 and

R 22 are independently H, methyl or ethyl.

21. The compound of claim 20 wherein:

R 3 is H; halo; C 1-3 alkyl; or C 1-3 alkoxy;

R 4 and R 6 are independently H; halo; NO 2 , N 3 ; C 1-6 alkyl; C 1-3 alkoxy; or —N(R 2b )(R 2c ) wherein R 2b and R 2c are independently H, OH, C 1-6 alkyl, C 1-6 hydroxyalkyl, C 1-6 acyl, C 1-6 acyloxy, C 1-6 acylamido, or C 1-6 alkyl that is optionally substituted with —N(R 2d )(R 2e ) wherein R 2d and R 2e are independently H, OH, C 1-3 alkyl or C 2-3 hydroxyalkyl, wherein R 2b and R 2c together may form a 3, 4, 5 or 6-membered heterocycle, and wherein R 2b and R 2c are not both OH, R 2d and R 2e are not both OH;

R 5 is H or F;

R 7 and R 11 are independently H; halo; CH 3 ; or OCH 3 ; and

R 8 and R 10 are independently H; halo; OH; N 3 ; C 1-3 alkyl; C 1-3 alkoxy; C 1-3 haloalkyl;

—OR 9a , —SR 9a , where R 9a is C 1-4 alkyl or C 1-3 haloalkyl; —NH(R a ) or —N(R a )(R b ) where R a and R b are independently C 1-3 alkyl; or —COOR 9b , wherein R 9b is C 1-3 alkyl;

wherein any heterocycle moiety comprises from one to four heteroatoms independently selected from O, N, and S.

22. A pharmaceutical composition comprising an effective amount of a compound according to claim 1 , and a pharmaceutically acceptable carrier.

23. A pharmaceutical composition comprising an effective amount of a compound according to claim 10 , and a pharmaceutically acceptable carrier.

24. A pharmaceutical composition comprising an effective amount of a compound according to claim 16 , and a pharmaceutically acceptable carrier.

25. A pharmaceutical composition comprising an effective amount of a compound according to claim 11 , and a pharmaceutically acceptable carrier.

26. The compound of claim 10 , wherein

R 3 is H; halo; C 1-3 alkyl; or C 1-3 alkoxy;

R 4 and R 6 are independently H; halo; NO 2 , N 3 ; C 1-6 alkyl; C 1-3 alkoxy; or —N(R 2b )(R 2c ) wherein R 2b and R 2c are independently H, OH, C 1-6 alkyl, C 1-6 hydroxyalkyl, C 1-6 acyl, C 1-6 acyloxy, C 1-6 acylamido, or C 1-6 alkyl that is optionally substituted with —N(R 2d )(R 2e ) wherein R 2d and R 2e are independently H, OH, C 1-3 alkyl or C 2-3 hydroxyalkyl, wherein R 2b and R zc together may form a 3, 4, 5 or 6-membered heterocycle, and wherein R 2b and R 2c are not both OH, R 2d and R 2e are not both OH;

R 5 is H or F;

R 7 and R 11 are independently H; halo; CH 3 ; or OCH 3 ; and

R 8 and R 10 are independently H; halo; OH; N 3 ; C 1-3 alkyl; C 1-3 alkoxy; C 1-3 haloalkyl;

—OR 9a , —SR 9a , where R 9a is C 1-4 alkyl or C 1-3 haloalkyl; —NH(R a ) or —N(R a )(R b ) where R a and R b are independently C 1-3 alkyl; or —COOR 9b , wherein R 9b is C 1-3 alkyl;

wherein any heterocycle moiety comprises from one to four heteroatoms independently selected from O, N, and S.