DELIVERY DEVICE HAVING SELF-ASSEMBLING DENDRITIC POLYMERS AND METHOD OF USE THEREOF
A device for delivery of one or more active agents to a biological interface includes a matrix having at least one dendritic polymer or arborol. In certain embodiments, the dendritic polymer or arborol self-assembles to form a matrix having aqueous pores or cavities to contain and allow transport of active agents or ions. In particular aspects, the device is an iontophoretic device. In certain aspects, the iontophoretic device may include an active electrode assembly having an active agent holding portion or reservoir; and a non-active electrode assembly.
1 . A device for delivery of one or more active agents to a biological interface, comprising:
a matrix comprising at least one dendritic polymer or arborol; and
at least one active agent.
2 . The device of claim 1 wherein the device is a transdermal delivery device.
3 . The device of claim 1 wherein the device is an iontophoretic device having at least two electrode structures.
4 . The device of claim 1 wherein the arborol is a one-directional arborol.
5 . The device of claim 4 wherein the one-directional arborol is a [9]-6 arborol, a [9]-8 arborol, or a [9]-10 arborol.
6 . The device of claim 1 wherein the arborol is a two-directional arborol.
7 . The device of claim 6 wherein the two-directional arborol is a [m]-n-[m] arborol wherein m is the number of polar groups comprising each of two hydrophilic end regions and n is the number of carbons in a linear alkyl chain connecting the two hydrophilic end regions.
8 . The device of claim 6 wherein the two-directional arborol is a [9]-n-[9] arborol wherein n is the number of carbons in a linear alkyl chain connecting two hydrophilic end regions each comprising 9 hydroxyl groups.
9 . The device of claim 8 wherein n is 10-13.
10 . The device of claim 9 wherein the two-directional arborol is a [9]-10-[9] arborol.
11 . The device of claim 1 wherein the arborol is a three-directional arborol.
12 . The device of claim 11 wherein the three-directional arborol is benzene[9 3 ].
13 . The device of claim 1 wherein the dendritic polymer is polyamidoamine (PAMAM) dendrimer.
14 . The device of claim 1 wherein the dendritic polymer is a polypropylene imine (PPI) dendrimer.
15 . The device of claim 1 wherein the dendritic polymer is a polyether or phenylacetylene dendrimer.
16 . The device of claim 1 wherein the matrix is a gel matrix.
17 . The device of claim 1 wherein the dendritic polymer or arborol is a self-assembling dendritic polymer or arborol.
18 . The device of claim 17 wherein the self-assembling dendritic polymer or arborol is a two-directional arborol.
19 . The device of claim 18 wherein the two-directional arborol is a [m]-n-[m] arborol wherein m is the number of polar groups comprising each of two hydrophilic end regions and n is the number of carbons in a linear alkyl chain connecting the two hydrophilic end regions.
20 . The device of claim 19 wherein the two-directional arborol is a [9]-n-[9] arborol wherein n is the number of carbons in a linear alkyl chain connecting two hydrophilic end regions each comprising 9 hydroxyl groups.
21 . The device of claim 20 wherein n is 10-13.
22 . The device of claim 21 wherein the two-directional arborol is a [9]-10-[9] arborol.
23 . The device of claim 1 wherein the active agent is a therapeutic agent, a diagnostic agent, or a pharmaceutical drug.
24 . The device of claim 1 , further comprising:
at least one reservoir.
25 . The device of claim 1 wherein the matrix comprising at least one dendritic polymer or arborol forms a reservoir.
26 . The device of claim 25 wherein the dendritic polymer or arborol is a self-assembling dendritic polymer or arborol.
27 . The device of claim 1 , further comprising:
at least one membrane.
28 . The device of claim 1 wherein the matrix comprising at least one dendritic polymer or arborol forms at least one membrane.
29 . The device of claim 28 wherein the dendritic polymer or arborol is a self-assembling dendritic polymer or arborol.
30 . The device of claim 29 wherein self-assembling the dendritic polymer or arborol forms at least one membrane.
31 . The device of claim 1 wherein the dendritic polymer or arborol comprises a charged group.
32 . The device of claim 31 wherein the charged group has a net positive charge.
33 . The device of claim 31 wherein the charged group has a net negative charge.
34 . The device of claim 1 , further comprising:
an interface-coupling medium between a surface of the device and the biological interface.
35 . The device of claim 34 wherein the interface-coupling medium is an adhesive.
36 . A device for delivery of one or more active agents to a biological interface, comprising:
a matrix comprising at least one dendritic polymer or arborol; and
an electrode structure.
37 . The device of claim 36 wherein the device is a transdermal delivery device.
38 . The device of claim 36 wherein the device is an iontophoretic device having at least two electrode structures.
39 . The device of claim 36 wherein the arborol is a one-directional arborol.
40 . The device of claim 36 wherein the arborol is a two-directional arborol.
41 . The device of claim 36 wherein the arborol is a three-directional arborol.
42 . The device of claim 36 wherein the dendritic polymer is polyamidoamine (PAMAM) dendrimer.
43 . The device of claim 36 wherein the dendritic polymer is a polypropylene imine (PPI) dendrimer.
44 . The device of claim 36 wherein the dendritic polymer is a polyether or phenylacetylene dendrimer.
45 . The device of claim 36 wherein the matrix is a gel matrix.
46 . The device of claim 36 wherein the dendritic polymer or arborol is a self-assembling dendritic polymer or arborol.
47 . The device of claim 46 wherein the self-assembling dendritic polymer or arborol is a two-directional arborol.
48 . The device of claim 47 wherein the two-directional arborol is a [m]-n-[m] arborol wherein m is the number of polar groups comprising each of two hydrophilic end regions and n is the number of carbons in a linear alkyl chain connecting the two hydrophilic end regions.
49 . The device of claim 36 wherein the active agent is a therapeutic agent, diagnostic agent, or a pharmaceutical drug.
50 . The device of claim 36 , further comprising:
at least one reservoir comprising a dendritic polymer or arborol.
51 . The device of claim 36 , further comprising:
at least one membrane comprising a dendritic polymer or arborol.
52 . The device of claim 36 wherein the dendritic polymer or arborol comprises a charged group.
53 . A method for making an active agent delivery device, comprising:
placing in a portion of the device a solution or suspension of a self-associating dendritic polymer; and
allowing the self-associating dendritic polymer to self associate.
54 . The method of claim 53 wherein the portion of the device is a reservoir.
55 . The method of claim 53 wherein the portion of the device is a membrane.
56 . The method of claim 53 wherein the self-associating dendritic polymer is an arborol.
57 . The method of claim 53 , further comprising: loading an active agent into pores or cavities created by self-association of the self-associating dendritic polymer.
58 . An active agent delivery device made according to the method of any one of claims 53 - 57 .