Joining tissues with composition containing bioabsorbable isocyanate compound
View Patent ↗Bioabsorbable compounds which include a polyalkylene oxide backbone with two or more isocyanate substituents are useful as one component adhesives. Absorbable compositions useful as a two component adhesive contain a) a polyethylene oxide having two or more amine substituents with b) a bioabsorbable diisocyanate compound, or alternatively contain a) a polyethylene oxide having two or more isocyanate substituents with b) a bioabsorbable diamine compound, or, alternatively contain a) a bioabsorbable diisocyanate compound and b) a bioabsorbable diamine compound.
1. A method comprising:
contacting tissue with a bioabsorbable compound of the formula:
R′ 4-n —C—(R) n
wherein the R′ groups can be the same or different at each occurrence and are each individually selected from the group consisting of —H and C 1 to C 8 alkylene groups, n is a number of from 2 to 4, and the R groups can be the same or different at each occurrence and are each individually selected from the group consisting of polyalkylene oxide groups and polyalkylene oxide groups substituted with at least one isocyanate group having the formula:
-[A] n -NCO
wherein A is a bioabsorbable group and n is from 1 to about 20,
with the proviso tat at least two of the R groups are polyalkylene oxide groups substituted with at least one isocyanate group; and
joining the tissue with other tissue to close a wound.
2. A method as in claim 1 , wherein the isocyanate groups include a bioab sorbable group derived from a monomer selected from the group consisting of glycolic acid, glycolide, lactic acid, lactide, 1,4-dioxane-2-one, 1,3-dioxane-2-one and ε-caprolactone.
3. A method as in claim 1 , wherein the polyalkylene oxide groups substituted with at least one isocyanate group have a terminal isocyanate group.
4. A method as in claim 1 , wherein the polyalkylene oxide groups are derived from one or more compounds selected from the group consisting of polyethylene oxide, polypropylene oxide and random or block copolymers of ethylene oxide and propylene oxide.
5. A method as in claim 4 , wherein the molecular weight of the polyalkylene oxide groups is in the range of 500 to 20,000.
6. A method as in claim 4 , wherein the molecular weight of the polyalkylene oxide groups is in the range of 1000 to 10,000.
7. A method as in claim 1 , wherein the polyalkylene oxide group has a branched structure.
8. A method as in claim 1 , wherein the bioabsorbable compound is partially cross-linked prior to contacting the tissue.