Morpholinyl and pyrrolidinyl analogs
View Patent ↗The present invention relates to 4′-[(1R)-1-[[(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin- 4-yl)acetyl](methyl)amino]-2-(4-morpholinyl)ethyl]-4-biphenylcarboxylic acid and its pharmaceutically acceptable salts, pharmaceutical compositions containing them, and their use as antagonists of urotensin II.
1. A compound which is 4′-[(1R)-1-[[(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)acetyl](methyl)amino]-2-(4-morpholinyl)ethyl]-4-biphenylcarboxylic acid; or a pharmaceutically acceptable salt thereof.
2. A compound of claim 1 which is 4′-[(1R)-1-[[(6,7- dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)acetyl](methyl)amino]-2-(4-morpholinyl)ethyl]-4-biphenylcarboxylic acid HCL salt.
3. A compound of claim 1 which is 4′-[(1R)-1-[[(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)acetyl](methyl)amino]-2-(4-morpholinyl)ethyl]-4-biphenylcarboxylic acid Trifluoroacetate salt.
4. A pharmaceutical composition comprising a compound of claim 1 and a pharmaceutically acceptable carrier or excipient.
5. A pharmaceutical composition comprising a compound of claim 2 and a pharmaceutically acceptable carrier or excipient.
6. A pharmaceutical composition comprising a compound of claim 3 and a pharmaceutically acceptable carrier or excipient.
7. A method of treating congestive heart failure, ischemic heart disease, angina, myocardial ischemia, overactive bladder, or cardiac arrhythmia which comprises administering to a patient in need thereof, a compound of claim 1 .
8. A method of treating hypertension which comprises administering to a patient in need thereof, a compound of claim 1 .
9. A method of treating hypertension which comprises administering to a patient in need thereof, a compound of claim 2 .
10. A method of treating hypertension which comprises administering to a patient in need thereof, a compound of claim 3 .