System for closing a tissue structure from inside

1. A method for closing an aneurysm, the aneurysm having a neck connected to a blood vessel, comprising:

providing a staple having a plurality of tines, said tines oriented at least partially in the proximal direction;

advancing said staple through the vasculature to a location within the aneurysm;

plastically deforming said staple to a splayed configuration;

penetrating at least one said tine of said staple in said splayed configuration into tissue in proximity to the neck of the aneurysm

plastically deforming said staple to a closed configuration, whereby the neck of the aneurysm is substantially closed; and providing an end effector, wherein said end effector holds said staple; and wherein said plastically deforming said staple to a splayed configuration and said plastically deforming said staple to a closed configuration are performed by said end effector.

2. The method of claim 1 , further comprising

providing a guidewire; and

advancing said guidewire through the vasculature until the distal end of said guidewire is located within the aneurysm;

wherein said advancing said staple is performed by advancing said end effector along said guidewire.

3. The method of claim 2 , wherein said penetrating is caused by moving said staple proximally along said guidewire.

4. The method of claim 1 , wherein said advancing comprises advancing said staple through the vasculature to a location completely within the aneurysm.

5. The method of claim 1 , wherein said end effector includes a housing, further comprising passively ejecting said staple from said housing after said plastically deforming said staple to a closed configuration.

6. The method of claim 5 , further comprising holding said staple completely within said housing before said plastically deforming said staple to said splayed configuration.

7. The method of claim 1 , wherein said advancing is performed without a guidewire.