Cyclosporin compositions
View Patent ↗Disclosed herein are therapeutic methods, compositions, and medicaments related to cyclosporine.
1. An aqueous solution comprising cyclosporin A at a concentration of about 0.0001% (w/v), Polysorbate 80, glycerin, mannitol, carboxymethylcellulose sodium, and water, wherein the aqueous solution contains no oil.
2. The solution of claim 1 , wherein the Polysorbate 80 is at a concentration of 1% (w/v), the glycerin is at a concentration of 1% (w/v), the mannitol is at a concentration of 0.5% (w/v), and the carboxymethylcellulose sodium is at a concentration of 0.5% (w/v).
3. The solution of claim 2 , further comprising sodium citrate dihydrate, potassium chloride, boric acid, and sodium borate decahydrate.
4. A method comprising topically administering a composition according to claim 1 to an eye of a mammal in need thereof to enhance or restore lacrimal gland tearing.
5. The method of claim 4 , wherein said method increases tear production in a tear-deficient eye.
6. The method of claim 4 , wherein said method is effective in treating keratoconjunctivitis sicca.
7. The method of claim 4 , wherein said method is effective in treating dry eye disease.
8. The method of claim 4 wherein the mammal is a human patient, and wherein less than 10% of human patients suffer burning or stinging when said composition is administered only once a day for a period of three months.
9. The method of claim 4 wherein the mammal is a human patient, and wherein less than 10% of human patients suffer ocular burning when said composition is administered only once a day for a period of three months.
10. The method of claim 4 wherein the composition is administered only once a day.