Modification of feeding behaviour
View Patent ↗The present invention relates to compositions and methods for use in the prevention or treatment of excess weight in a mammal. The compositions comprise oxyntomodulin which is shown to reduce food intake and/or increase energy expenditure.
1. A method for the prevention or treatment of excess weight in a subject mammal, which comprises administering oxyntomodulin and PYY to the subject.
2. The method according to claim 1 , which is a method for the reduction or prevention of obesity.
3. The method according to claim 1 , which comprises administering PYY 3-36 .
4. The method according to claim 1 , wherein the oxyntomodulin is administered via a route peripheral to the brain.
5. The method according to claim 1 , wherein the PYY is administered via a route peripheral to the brain.
6. The method according to claim 4 , wherein the oxyntomodulin is administered by a route selected from the group consisting of oral, rectal, intravenous, intramuscular, intraperitoneal, buccal, sublingual, nasal, subcutaneous, and transdermal administration.
7. The method according to claim 5 , wherein the PYY is administered by a route selected from the group consisting of oral, rectal, intravenous, intramuscular, intraperitoneal, buccal sublingual, nasal, subcutaneous, and transdermal administration.
8. The method according to claim 1 , wherein the oxyntomodulin is administered peripherally at a dose of 0.1 nmoles or more per kg body weight of the subject.
9. The method according to claim 1 , wherein the oxyntomodulin is administered peripherally at a dose of up to 12 nmoles per kg body weight.
10. The method according to claim 1 , wherein the oxyntomodulin is administered at a dose of 0.5 mg to 2 mg before meals.
11. The method according to claim 1 , wherein the PYY is administered peripherally at a dose of 0.1 nmoles per kg body weight of the subject or more.
12. The method according to claim 1 , wherein the PYY is administered peripherally at a dose of up to 3.2 nmoles per kg body weight.
13. The method according to claim 1 , wherein the oxyntomodulin and the PYY are administered simultaneously, or sequentially in any order.