Antibodies that bind human protein tyrosine phosphatase beta (HPTPβ)
View Patent ↗Antibodies and antigen binding fragments thereof that bind to human protein tyrosine phosphatase beta (HPTPβ), and uses thereof.
1. An isolated antibody or antigen-binding fragment thereof which binds to human protein tyrosine phosphatase beta (HPTPβ), wherein said antibody or antigen-binding fragment thereof regulates angiogenesis.
2. The antibody or antigen-binding fragment thereof according to claim 1 , wherein the antibody or antigen-binding fragment thereof binds the N-terminal portion of HPTPβ.
3. The antibody or antigen-binding fragment thereof according to claim 2 , wherein the antibody or antigen-binding fragment thereof binds the first FN3 repeat of HPTPβ.
4. The antibody or antigen-binding fragment thereof according to claim 3 , wherein the first FN3 repeat of HPTPβ has the sequence as shown in SEQ ID NO:11.
5. The antibody or antigen-binding fragment thereof according to claim 1 , wherein the antibody is a monoclonal antibody or antigen-binding fragment thereof.
6. The monoclonal antibody according to claim 5 produced by hybridoma cell line ATCC No. PTA-7580 or the antigen-binding fragment of the monoclonal antibody according to claim 5 produced by hydriboma cell line ATCC No. PTA-7580.
7. The antibody or antigen binding fragment thereof according to claim 1 , wherein the antibody or antigen binding fragment thereof is humanized.
8. The antibody or antigen-binding fragment thereof according to claim 6 , which comprises antigen binding region residues from the monoclonal antibody R15E6, ATCC No. PTA-7580, and is humanized.
9. The antigen binding fragment according to claim 7 , wherein the fragment comprises heavy and light chain variable regions.
10. An antigen binding fragment according to claim 7 , wherein the antigen-binding fragment is selected from the group consisting of an Fv fragment, and Fab fragment, an Fab' fragment, and an F(ab') 2 fragment.
11. The monoclonal antibody R15E6, produced by hybridoma cell line ATCC No. PTA-7580 which binds to human protein tyrosine phosphatase beta (HPTPβ).
12. A pharmaceutical composition, comprising:
a. the antibody or antigen-binding fragment thereof according to claim 1 , and
b. a pharmaceutically acceptable carrier.
13. A pharmaceutical composition, comprising:
a. the antibody or antigen-binding fragment thereof according to claim 6 , and
b. a pharmaceutically acceptable carrier.
14. A pharmaceutical composition, comprising:
a. the antibody or antigen-binding fragment thereof according to claim 7 , and
b. a pharmaceutically acceptable carrier.
15. A pharmaceutical composition, comprising:
a. the antibody or antigen-binding fragment thereof according to claim 8 , and
b. a pharmaceutically acceptable carrier.
16. A pharmaceutical composition, comprising:
a. the antibody according to claim 11 or a fragment thereof; and
b. a pharmaceutically acceptable carrier.