Systems and methods for ex vivo organ care

1. A lung care system comprising:

a portable multiple use module including a portable chassis;

a first electromechanical connector disposed on the portable multiple use module;

a single use disposable module including:

a disposable structure including a second electromechanical connector disposed thereon that is sized and shaped for interlocking the single use disposable module with the multiple use module for electromechanical inter-operation with the multiple use module, wherein the second electromechanical connector is configured to electromechanically couple to the first electromechanical connector, and

a lung chamber assembly having a first interface for allowing a flow of perfusion fluid into the lung, a second interface for allowing ventilation of the lung, and a third interface for allowing a flow of the perfusion fluid away from the lung;

a pump adapted to flow the perfusion fluid into and away from the lung; and

a respiratory gas source having a predetermined composition of oxygen;

a ventilator coupled to the respiratory gas source and the second interface;

a gas exchange device configured to controllably alter a composition of a first gas component in the perfusion fluid;

at least one processor coupled to a non-transitory memory storing instructions that, when executed by the at least one processor:

cause the ventilator to ventilate the lung by flowing respiratory gas into the lung via the second interface in periodic breaths containing a predetermined volume of and pressure of the respiratory gas;

cause the ventilator to maintain a predetermined minimum positive end-expiratory pressure, and

cause the gas exchange device to modulate the composition of the first gas component in the perfusion fluid as a function of the amount of oxygen in the respiratory gas provided to the lung;

wherein the lung chamber assembly includes a flexible membrane that suspends the lung within the lung chamber assembly for supporting the lung and maintaining a shape of the lung.

2. The system of claim 1 , wherein the first interface includes a pulmonary artery cannula, and the second interface includes a cannula disposed within a tracheal conduit of the lung.

3. The system of claim 1 , wherein the third interface includes a cup shaped interface and the cup-shaped interface includes a plurality of openings at respective heights along a sidewall of the interface.

4. The system of claim 3 , wherein the third interface includes a selector valve in fluid communication with the plurality of openings for controllably drawing the perfusion fluid in the cup-shaped interface away from the lung chamber assembly via a selected one of the plurality of openings and an outlet conduit.

5. The system of claim 1 , wherein the flexible membrane substantially prevents the lung from contacting at least one wall of the lung chamber assembly.

6. The system of claim 1 , wherein the flexible membrane is a netting.

7. The system of claim 1 , wherein the lung chamber assembly has a shape of a ribcage.

8. The system of claim 1 , wherein the lung chamber assembly includes a diaphragm structure.

9. The system of claim 1 , comprising a heater for maintaining the perfusion fluid provided to the lung chamber assembly at a near physiologic temperature.

10. The system of claim 9 , wherein the temperature is between about 30° C. and about 37° C.

11. The system of claim 10 , wherein the temperature is between about 34° C. and about 37° C.

12. The system of claim 1 , wherein the gas exchange device includes a gas select switch for selecting from a plurality of gas supplies to modulate the composition of a gas component in the perfusion fluid.

13. The system of claim 1 , comprising an isolated volume compartment cannulated to a tracheal conduit of the lung and adapted to ventilate the lung during perfusion.

14. The system of claim 1 , comprising an oxygenation sensor for measuring an oxygen content in the perfusion fluid.

15. The system of claim 1 , comprising an oxygenation sensor adapted to provide a signal indicative of a hematocrit measurement of the perfusion fluid.

16. A lung care system comprising:

a portable multiple use module including a portable chassis;

a first electromechanical connector disposed on the portable multiple use module;

a single use disposable module including,

a disposable structure including a second electromechanical connector disposed thereon that is sized and shaped for interlocking the single use disposable module with the multiple use module for electromechanical inter-operation with the multiple use module, wherein the second electromechanical connector is configured to electromechanically couple to the first electromechanical connector, and

a lung chamber assembly having a first conduit for allowing a flow of perfusion fluid into the lung, a second conduit for allowing ventilation of the lung, and a third conduit for allowing a flow of the perfusion fluid away from the lung;

a pump adapted to flow the perfusion fluid into and away from the lungs; and

a respiratory gas source in communication with the second conduit;

a ventilator coupled to the respiratory gas source and the second conduit;

a gas exchange device configured to controllably alter a composition of a first gas component in the perfusion fluid; and

at least one processor coupled to a non-transitory memory storing instructions that, when executed by the at least one processor:

cause the ventilator to ventilate the lung by flowing respiratory gas into the lung via the second conduit in periodic breaths containing a predetermined volume of and pressure of the respiratory gas;

cause the ventilator to maintain a predetermined minimum positive end-expiratory pressure, and

cause the gas exchange device to modulate the composition of the first gas component in the perfusion fluid as a function of the amount of oxygen in the respiratory gas provided to the lung;

a perfusion circuit in communication with the first and third conduits wherein the third conduit is configured to connect to pulmonary veins of a lung and a left atrial cuff.

17. The system of claim 16 , wherein the third conduit has a funnel shaped end.

18. The system of claim 1 wherein the single use disposable module further includes an optical interconnection configured to be coupled to a corresponding connection on the multiple use module.

19. The system of claim 16 wherein the single use disposable module further includes an optical interconnection configured to be coupled to a corresponding connection on the multiple use module.