Coated filaments
View Patent ↗The present disclosure describes a coating for a surgical filament including a vinyl lactam polymer and a lactone polymer.
1. A medical device comprising at least one filament having a partitioned coating formed from a coating composition comprising a blend of a vinyl lactam polymer and a lactone polymer miscible in a common solvent wherein said partitioned coating is formed after driving off the common solvent.
2. The medical device of claim 1 wherein the vinyl lactam polymer comprises monomeric units selected from the group consisting of N-vinyl-pyrrolidone, N-vinyl-2-piperidone, and N-vinyl-caprolactam, N-vinyl methyl pyrrolidone, N-vinyl ethyl pyrrolidone, N-vinyl methyl caprolactam, and combinations thereof.
3. The medical device of claim 1 wherein the vinyl lactam polymer is polyvinyl pyrrolidone.
4. The medical device of claim 1 wherein the lactone polymer comprises polymers derived from monomeric units selected from the group consisting of lactide, glycolide, caprolactone, dioxanone, propiolactone, butyrolactone, valerolactone, decalactone, pivalolactone, stearolactone, palmitolactone, trimethylene carbonate and combinations thereof.
5. The medical device of claim 1 wherein the coating further comprises a metallic salt or fatty acid ester salt.
6. The medical device of claim 1 wherein the filament is a suture.
7. A medical device comprising a filament having a phase separated coating formed from a coating composition comprising a blend of a vinyl lactam polymer and a lactone polymer and a fatty acid ester salt wherein the polymers are miscible in a common solvent and said phase separated coating is formed after driving off the common solvent.
8. The medical device of claim 7 wherein the vinyl lactam polymer comprises monomeric units selected from the group consisting of N-vinyl-pyrrolidone, N-vinyl-2-piperidone, and N-vinyl-caprolactam, N-vinyl methyl pyrrolidone, N-vinyl ethyl pyrrolidone, N-vinyl methyl caprolactam, and combinations thereof.
9. The medical device claim 7 wherein the lactone polymer comprises monomeric units selected from the group consisting of lactide, glycolide, caprolactone, dioxanone, propiolactone, butyrolactone, valerolactone, decalactone, pivalolactone, stearolactone, palmitolactone and combinations thereof.
10. The medical device of claim 7 wherein the vinyl lactam polymer is polyvinyl pyrrolidone.
11. The medical device of claim 7 further comprising a hydrophilic drug.
12. The medical device of claim 7 further comprising a hydrophobic drug.
13. The medical device of claim 7 further comprising a hydrophilic and a hydrophobic drug.
14. A medical device comprising a filament having a phase separated coating formed from a coating composition comprising a drug, a coupling agent, and a blend of a vinyl lactam polymer and a lactone polymer wherein the polymers are miscible in a common solvent and said phase separated coating is formed after driving off the common solvent.
15. The medical device of claim 14 wherein the coupling agent is selected from the group consisting of peptides, enzymes, proteins, nucleotides, amino acids, polyamino acids, and polypeptides.
16. The medical device of claim 14 wherein the coupling agent comprises a polyvalent compound.
17. The medical device of claim 16 wherein the polyvalent compound comprises a branched hydrocarbon chain having 2 to 25 carbon atoms.
18. The medical device of claim 14 wherein the coupling agent is a thermoreversible material.
19. The medical device of claim 18 wherein the thermoreversible material comprises polyethylene oxide, polypropylene oxide, poly(N-isopropyl acrylamide) and combinations thereof.
20. The medical device of claim 14 wherein the drug comprises a hydrophobic drug.
21. A method of forming a partitioned coating on a filament comprising:
forming a blend of a vinyl lactam polymer and a lactone polymer, wherein the polymers are miscible in a common solvent,
applying the blend to the filament, and
driving off the common solvent.